Panthenoic Acid & Biotin

Front 1

Pantothenic acid is used to form a part of

Back 1

CoA

Front 2

Pantothenic acid = ______ acid + _______

Back 2

Pantoic, beta-alanine

Front 3

Digestion of Pantothenic acid is found in food in ____ and ___ forms

Back 3

Free and bound

Front 4

CoA form _____ in GI tract lumen to free form

Back 4

hydrolyzed

Front 5

High concentration of PTA use what transport

Back 5

Passive diffusion

Front 6

Low concentrations of PTA use what transport

Back 6

Na+ dependent multivitamin transporter
SMVT

Front 7

Flow of transport of PTA

Back 7

Intestinal cells --> portal blood __> liver

Front 8

Where is PTA absorbed

Back 8

Jejunum

Front 9

Synthesis of CoA requires which 3 things

Back 9

PTA, cysteine, ATP

Front 10

Syn of CoA starts with rate limiting phosphorylation of PTA by what and where?

Back 10

Pantothenic kinase in the cytosol

Front 11

The function of CoA is for ____ of:

Back 11

Acetylation of proteins, sugars, drugs...

Front 12

Addition of acyl group 2-13C long

Back 12

Acylation

Front 13

Pantothenic acid is transported in its free form within

Back 13

RBCs

Front 14

Acetyl CoA formation requries which 4 things?

Back 14

PTA, thiamin, niacin and riboflavin

Front 15

Acetylation of DNA is an _____ mark that regulates gene expression

Back 15

Epigenetic

Front 16

Where is PTA excreted?

Back 16

In urine, and small in feces. Most is absorbed so small excretion

Front 17

ADI for PTA

Back 17

Adults: 5mg

Pregnant: 6mg

Lactation: 7mg

Front 18

Syndrome associated with PTA deficiency

Most occurs with malnutrition

Back 18

Burning Feet Syndrome

Front 19

Discovery of Biotin was related to excessive consumption of what?

Back 19

Raw eggs

Front 20

Found substance in liver that prevented hair loss from egg white

Back 20

Szent-Gyorgyi

Front 21

Anti-vitamin to bition found in egg whites which binds to biotin preventing absorption

Back 21

Avidin

Front 22

Digestion of Biotin is bound to?

Back 22

Protein

Front 23

Digestion of Biotin is aided by proteolytic enzymes like

Back 23

Pepsin, SI Proteases/peptidases, Biotinidase

Front 24

Found in the brush border, pancreatic, and intestinal juices that hydrolyzes biocytin

Back 24

Biotinidase

Front 25

From food Biotin is absorbed as

Back 25

Free biotin in the jejunum, then illeum

Front 26

From bacteria Biotin is absorbed in

Back 26

proximal and midtransverse colon

Front 27

With pharmacologic doses Biotin is absorbed by what transport

Back 27

Passive diffusion

Front 28

Biotin shares PTA transporter called

Back 28

SMVT

Front 29

Biotin is involved w/ the gene expression of over _____ human genes

Back 29

2,000

Front 30

Biotin is important in the oxidation of propionyl CoA to

Back 30

methylmaloynl-CoA

Front 31

The precursor to Oxaloacetate is

Back 31

Pyruvate

Front 32

Biocytin = biotin + ___

Back 32

lysine

Front 33

Biotin can be recycled by binding to ___ and then freed by ___

Back 33

lysine, biotinidase

Front 34

Intake for Biotin is

Back 34

30ug

Front 35

Deficiency of Biotin may be caused by

Back 35

genetic mutation of biotinidase

Front 36

Biotin may be absorbed as

Back 36

biocytin