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26 Cards in this Set
- Front
- Back
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Classification of Pancreatic Endocrine Tumors?
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WELL DIFFERENTIATED
functioning non-functioning POORLY DIFFERENTIATED MIXED EXOCRINE-ENDOCRINE TUMOR |
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Types of Functioning Well Differentiated Pancreatic Endocrine Tumors?
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Insulinoma
Gastinoma Glucagonoma Somatostatinoma VIPoma Serotonin producing w/ carcinoid syndrome ACTH-producing--> cushings |
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Types of Non-Functioning well differentiated Pancreatic Endocrine Tumors?
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Microadenomas...
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Types of Poorly differentiated Pancreatic Endocrine Tumors?
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Small Cell Carcinoma
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Most common well differentiated Pancreatic Endocrine Tumors?
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NON-FUNCTIONING
then insulinoma.... |
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Differentiation of Insulinoma?
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beta cells
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Sx's of Insulinoma?
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HYPOGLYCEMIA
Neuro effects secondary to hypoglycemia Autonomic Response |
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malignant or benign for insulinoma?
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90% benign
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Morphology of Insulinoma?
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Well Circumscribed
75% < 2cm Histo is bland Cells positive for insulin |
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What are the neuro effect seen in response to hypoglycemic from insulinoma?
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Blurred/Double Vision
Confusion Stupor/LOC Seizures |
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Autonomic Response associated w/ Insulinoma?
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Sweat
Tremor and Palpitations Hunger Nausea Anxiety Weak |
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Sx's of Gastrinoma?
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Looks like Zollinger-Ellison Syndrome
Abd Pain due to ulcer or GERD Diarrhea |
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Other locations besides pancreas (50%) for gastrinoma?
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Small Intestine
Peripancreatic tissue |
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Where can you get an ulcer secondary to Gastrinoma
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Duodenum
Stomach Jejunum |
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Gastrinomas are usually Malignant/Benign?
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Most are malignant but low grade and indolent
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Morphology of gastrinomas?
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Well Circumscribed
Mostly in pancreatic head Pancreatic > 2cm Duodenal < 1cm Histo: bland, but positive for gastrin |
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Differentiation of Glucagonoma?
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Alpha-Cell
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Clinical Syndrome associated w/ glucagonoma?
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Necrolytic Migratory Erythema
Mild DM Anemia Diarrhea Depression Deep Venous Thrombosis |
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Malignant or benign for glucagonoma?
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Usually malignant but indolent
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Somatostatinoma differentiation?
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Delta cell
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Clinical Syndrome Associated w/ Somatostatinoma?
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DM
Hypochlorhydia Cholelithiasis Diarrhea and Steatorrhea Anemia |
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Malignant or benign for somatostatinoma?
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malignant but indolent
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MEN and Pancreatic Neoplasms?
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MEN1 !!!!
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likelihood of pancreatic tumor in MEN1?
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30-75% by screening
near 100% by autopsy |
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What type of pancreatic tumor normal seen w/ MEN1?
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Multiple Non-Functioning microcarcinomas
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If the MEN1 pancreatic tumor is clinical manifesting (fxn's), what type is it most likely?
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#1 gastrinoma
#2 insulinoma |
