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1158 Cards in this Set
- Front
- Back
“Ash leaf” hypopigmentation of trunk & Ext, shagreen patch, sebaceous adenomas, seizures, mental retardation; Ass. w/ PCK, renal hemartomas
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Tuberous sclerosis
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< 2 days post-op with fever
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Atelectasis
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< 2mo fever
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Septic w/u - blood Cx, LP
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< 40 yo male with Fever, perineal pain, dysuria.
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Acute prostatitis caused by Chlamydia & N. gonorrhea. Treat accordingly (Bactrim #2 choice). > 40yo think e. coli is cause (Tx w/ FQ)
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< 5yo fever, seizures
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Febrile seizure
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< 70 yo blindness
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DM retinopathy (MCC)
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<35 yo, college students. Fever, cough, +/- sputum, chills, muscle aches
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Mycoplasma pneumonia
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> 70 yo blindness
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Macular degeneration
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>35yo with PNA. Rusty colored or yellow-green sputum. Acute onset F/C
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Strep. Pneumonia
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>50 yo female w/ HA. Temporal artery tenderness or blindness
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Temporal arteritis (Giant cell arteritis). Elevated ESR, get temporal artery biopsy
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>50 yo obstructive voiding sx, nocturia. Firm smooth enlarged prostate. Nl PSA
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BPH. (Cancer would have firm, irregular, nodular non-tender prostate, elevated PSA)
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>60yo F, LLQ pain
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Diverticulitis. IV Abx, fluids, NPO.
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12 – 15yo overweight male knee pain, limp, hip pain (knee XR normal)
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SCFE
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1st tooth (central incisor)
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6 – 8 mo
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20yo female w/ rubbery, firm, well-circumscribed, non-tender breast lesion, doesn’t change w/ cycle
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Fibroadenoma
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3 mHz spikes on EEG
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Absence (petit-mal) seizures.
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3 words, fees self w/ spoon, builds tower
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24 mo
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30 – 50yo female, painful, multiple, bilateral breast masses that increase in pain and size before menses
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Fibrocystic breast disease
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45,X – low hairline, low set ears, webbed neck, short stature; shield chest, wide set nipples, infertility, lack of Secondary sex characteristics
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Turners (gonadal dysgenesis
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6cm unilateral, mobile, tender adnexal mass
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Tubo-ovarian abscess
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8 – 10yo male with limp, knee pain
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Legg-Calve-Perthes Disease
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Abdominal distension, bloating, intermittent, colicky pain, high-pitched rushes & tinkles
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SBO
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Abdominal pain, diarrhea after picnic/party. Eaten ham, cream, custards, mayonnaise
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Staphylococcus aureus infectious diarrhea
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Acetowhitening
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Condyloa acuminata
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Acute bacterial diarrhea w/ prodrome of HA, F, then crampy abd pain & diarrhea
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Campylobacter jejuni – most common cause of acute bacterial diarrhea
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Acute joint pain. Swollen, warm, erythema.
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Septic arthritis (synovial fluid = leukocytosis, low glucose)
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Acute Painful red eye, halos (or colored rings around lights), hazy, steamy cornea. Pupil is fixed and (mid) dilated. Onset after being in dark room
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Acute angle-closure glaucoma
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Acute steroid withdrawal
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Addison’s disease, crisis
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Acute swollen big toe
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Gout
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Adolescent female w/ HA. +FHx. Severe HA, N/V, photphobia. +/- auras
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Migraine HA
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Adolescent female with midcycle pain alternating from left to right side. Relieved w/ NSAIDs
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Mittelschmerz
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Adolescent male with knee pain, tenderness over tibial tuberosity
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Osgood-schlatter disease
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Afebrile, watery or loose stool. No blood or mucus
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Viral Gastroenteritis
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Afferent papillary defect, marcus-gunn pupils
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Optic nerve lesion. Tertiary syphilis (marcus-gunn)
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AFP
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Hepatocellular carcinoma, testicular seminoma (germ cell tumor)
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Air fluid levels on upright abd plain film
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SBO
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Air under diaphragm, rigid board-like abdomen
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Perforated viscus, perforated ulcer
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Airway edema with eosinophils, neutrophils, lymphocytes
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Asthma
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Alcoholic with DOE, heart failure
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Primary dilated CM
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Alcoholic with massive hemoptysis
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Esophageal varicies (Tx w/ octreotide)
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Alcoholic with palpitations, arrhythmia
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Atrial fibrillation (Holiday heart)
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Anemia after colectomy, partial gastrectomy. Glossitis, decreased vibratory sensation
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B12 or Pernicious anemia
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Antidepressant use w/ anticholinergic side effects, dry mouth, dysrhythmias, sedation, orthostatic hypotension
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TCA overdose
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Anti-endomysial antibodies
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Celiac Sprue
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Antipsychotic meds (phenotiazines), facial tics, lip smacking, tongue disorders, blinking, ataxia
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Tardive dyskinesia
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Apical infiltrates, F, C, dry cough
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TB
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Apple core lesion
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Colon Cancer
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Ascending paralysis
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GBS
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Atrial fibrillation or prosthetic valve
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Warfarin (2 – 3 for Afib; 2.5 – 3.5 for valve); Tx Warfarin OD is vitamin K
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Attacks of severe HA, HTN, glucosuria
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Pheochromocytoma – Tx pre-op w/ alpha blocker
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Auer rods
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AML
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Beefy red, sharp bordered rash in groin (infants), under breast folds with satellite lesions
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Candida: Tx: Nystatin/Lotrimin cream QID x14d; if fails Ketoconazole
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Beriberi
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Thiamine; Alcoholics, Neuro Sx
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Bilateral DILATED pupils
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Anticholinergics, TCA, anti-parkinsonian drugs, profound hypoxemia
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Bilateral hemianopia
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Optic chiasm lesion
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Bilateral pinpoint pupils
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Pontine hemorrhage
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Binge eating, laxative use, starvation
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Bulimia nervosa (Tx w/ SSRI – Fluoxetine)
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Bite w/ fever, lacrimation, rhinorrhea, bradycardia, HTN, tachyarrhythmias
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Black widow (neurotoxin)
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Bite with local edema, erythema, central necrosis
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Brown recluse
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Bloody Diarrhea
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Ulcerative colitis
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Blue extremities worse w/ cold exposure, improves w/ warming
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Acrocyanosis
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Breast mass, nipple retraction, bloody nipple discharge
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Breast cancer (mass is most common presenting clinical manifestation)
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Bulimia with electrolyte disorders
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Hypokalemia, metabolic alkalosis
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Bullous myringitis
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Mycoplasma pneumonia
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CA 19-9
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Pancreatic Ca
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CA-125
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Ovarian Carcinoma
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Can’t retract foreskin
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Phimosis
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Cavitations on CXR
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Infections – lung abscess, TB (Gohn focus)
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CEA
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Colon Carcinoma
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Central obesity, abdominal stria, hyperglycemia, moon facies, buffalo hump, easy bruising
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Cushing syndrome
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Chemotherapy induced N&V
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Treat with Ondansetron (Zofran) (5-HT3 blockers)
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Children < 10yo w/ vesicles on pharynx, mouth, hands, feet w/ NO ulceration
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Hand-Foot-Mouth disease. Coxksackie Virus
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Choking, cyanosis, respiratory distress, increased secretions in 1st hours of life
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Tracheoesophageal fistula
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Christmas tree pattern, erythematous papules w/ oval plaues w/ scaly itchy border. Rash preceded by lagre oval plaque w/ central clearing & scaly border
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Pityriasis rosea; Herald patch
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Chronic cough, bitter taste in mouth or throat, dyspepsia
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GERD
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Claudication with rest pain, (ABI < 0.4)
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Tx is arterial bypass
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Clear vulvar vesicles, inguinal LAD
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Herpes virus (Genital)
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Cold induced pain at extremities with color change as they warm up
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Raynaud’s phenomenon
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College student with sore throat. Enlarged tonsils, anterior cervical LAD. Splenomegaly. CBC – elevated atypical lymphoctyes
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EBV - mononucleosis
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Concave
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Subdural Hematoma
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Concentrated urine. Hyponatremia
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SIADH
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Conjunctivitis, iritis, arthritis, cervicitis, urethritis
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Reiter’s syndrome
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Constant, sharp CP worse lying down, better sitting up and leaning forward
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Pericarditis
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Continuous bleeding post-op or trauma. Given multiple blood transfusions. Low platelets, increased PT, INR, + fibrin split products (increased d-dimer)
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DIC
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Continuous harsh, machine-like murmur
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PDA
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Cough, coryza, conjunctivitis
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Rubeola (Measles)
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Crush injury, alcoholic on ground, elevated CPK, ARF
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Rhabdomyolysis
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Crushing CP, dyspnea, palpitations, radiation to neck or left arm
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Angina (if lasts minutes), AMI if lasts > 30 minutes. Acute Ischemia – ST elevation; Injury – T wave depression; Infarct – Q wave
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Curtain or veil over my eyes, new onset floaters
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Retinal detachment
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Cyanotic infant with systolic thrill @ LSB, systolic ejection murmur +/- click
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Tetralogy of falot
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Cystic fibrosis w/ PNA
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Pseudomonas aueroginosa causative agent
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Dark skinned person with “whitening or lightening” of skin. Hx pernicious anemia or other autoimmune disease
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Vitiligo. Skin biopsy to diagnose
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Decreased radioactive iodine uptake, decreased free T4, increased TSH
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Hashimoto’s thyroiditis
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Deep breathing alternating w/ apnea
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Cheyne-Stokes breathing – heart failure, brain damage
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Deterioration of cognitive function, memory
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Dementia
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Dewdrops on rose petal, pustules & vesicles at different stages of healing
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Varicella (Chicken Pox)
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Dexamethasone suppression test
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Cushing syndrome
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Diabetic w/ anorexia, anemia, wt loss, pallor
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CRF
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Diabetic, ear pain
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MOE, Pseudomonas, IV abx (FQ), CT head
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Diamond shaped, blowing systolic murmur. May have angina, syncope, CHF
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Aortic stenosis
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Diastolic murmur best heart at apex without radiation
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Mitral stenosis (ARMS are BAD)
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Diplopia, dysarthria, dysphagia
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Vertibrobasilar insufficiency
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Distinct, sharp raised demarcated border with fever, chills. Group A Strep
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Erysipelas
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Dix-hallpike maneuver
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BPPV
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DM & HTN Tx
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ACEI is best choice
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DOE, PND, edema. Echo w/ LVH or RVH, hypokinesis
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CHF
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Drooling, sniffing position, tripod, toxic
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Epiglottitis
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dusky red, well localized single or multiple papules or plaques usually of face
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Discoid lupus
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Dysmenorrhea, dyspareunia, dyschezia. Uterus is fixed, retroflexed. Cyclic pelvic pain. May have palpable pelvic mass
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Endometriosis. Palpable pelvic mass – “chocolate cyst”
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Dyspnea after surgery, travel (airplane), LE Fx. May have c/o calf pain also.
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DVT/PE
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Eggshell pattern on CXR
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Silicosis (Sandblasters)
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EKG changes, N, V, yellow-green visual disturbances
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Digoxin toxicity (Hypokalemia will make worse)
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Elderly w/ systolic murmur
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Aortic stenosis (due to calcifications – age related (or bicuspid valve - congenital)
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Elderly with positive hemmocult.
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Colon Cancer – get colonoscopy
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Elderly, Hx atherosclerosis. Dull crampy periumbilical pain post-prandial
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Mesenteric ischemia
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Electrical alternans, narrow pulse pressure, pulsus paradoxus
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Pericardial effusion/tamponade
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Elevated Alkaline phosphatase, urinary bilirubin
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Cholecystitis
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Elevated AST, ALT, indirect bilirubin
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Hepatitis
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Elevated Hgb, Hct, splenomegaly, post showering pruritis, plethora, engorged retinal veins
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Polycythemia vera; Tx = Phlebotomy
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Elevated indirect bilirubin w/ defective glucuronyl transferase
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Crigler-Najjar Dz
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Enlarged PID, DIP
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Osteoarthritis (herberden – PIP; bouchard – DIP)
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Erythema marginatum
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Rheumatic Fever
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Erythema nodosum
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Systemic autoimmune diseases (RA, IBD), OCP
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Erythematic ring with scaly border & central clearing
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Tinea (fungal infection); KOH prep = hyphae
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Erythematous, dome-shaped nodule with central plug
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Keratoacanthoma
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Exogenous corticosteroid use
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Cushing syndrome
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Exopthalmos, palpitations, wt. loss. Elevated radioactive idodine uptake
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Hyperthyroid, Graves Dx – Tx w/ Radioactive iodine
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Extrapyradimidal signs, BP changes, altered consciousness, hyperpyrexia, muscle rigidity, dysarthria, CV instability, fever, pulmonary congestion, diaphoresis. Pt on antipsychotic meds
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Neuroleptic malignant syndrome. Tx supportive care & antipyretics
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Eye trauma, diplopia. Exophthalmos, fixed upward gaze, hyphema
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Orbital blow-out fracture; Immediate ophthalmology referral
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F, RUQ pain, Jaundice, gallstones & dilated common duct on US
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Ascending cholangitis (Charcot’s triad)
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Family history of young age colon cancer, multiple polyps found on colonoscopy
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Familial adenomatous polyposis (Gardner’s syndrome)
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Fat, forty, female, fertile w/ RUQ pain
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Cholelithiasis or Cholecystitis
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Fatigue, PM sweats, weight loss, painless LAD or neck mass
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Lymphoma – do Lymph node biopsy. Bone marrow Bx and CT scan used for staging
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Fatigue, weakness, low fever, purpura, pallor, gingival bleeding. No HSM
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Aplastic anemia
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Feelings of worthlessness, hopelessness, apathy, weight loss, insomnia, daytime sleepiness. Thoughts of suicide
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Depression (SSRI = drug of choice)
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Female exam, asymmetric posterior chest wall or uneven scapula height with forward bending
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Scoliosis (> 25 degree Cobb angle = surgery)
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Female morning joint pain & stiffness esp. hand/wrists. MCP joint swelling, ulnar deviation
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Rheumatoid arthritis. Methotrexate (DMARDs) #1.
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Female or Post MI, systolic murmur best @ apex preceded by click without radiation
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Mitral valve prolapse
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Female with acute abdominal pain. No characteristic acute abdomen pattern
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Ectopic pregnancy
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Female with Arthralgias, malar rash, +ANA, + anti-double stranded DNA antibodies, +anti-phospholipid antibodies
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SLE
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Female with recurrent abdominal pain, alternating diarrhea, constipation. Pain relieved with defecation.
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IBS. TCA’s (nortriptyline) good if diarrhea predominant symptom
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Female, fatigue, general aching, pain at neck, upper shoulders, sleeping problems, tender points
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Fibromyalgia (exercise program good management)
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Female, weight loss, palpitations, atrial fibrillation
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Hyperthyroid (work it up with TSH, T4)
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Fever, cough, sputum. Crackles, decreased breath sounds, dullness to percussion, +egophony, pectoriloquy. CXR – infiltrates or consolidation
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Pneumonia
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Fever, pharyngitis, “sandpaper” rash over face, neck, trunk, extremities
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Scarlet Fever
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Fever, RUQ pain, radiation to back
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Cholecystitis
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Fibrous band on lateral penis
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Peyronie’s disease
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Firm irregular shaped, NONTENDER enlarged uterus
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Leiomyoma
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Fishy odor, Thin grayish vaginal discharge, Clue cells
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Bacterial vaginitis; Gardnerella vaginalis
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Flank pain, hypotension, pulsatile abdominal mass
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AAA
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Flat brown spots with sharp borders on dorsum of hand
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Lentigines
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Flesh-colored, pink or yellow-brown lesion with rough, sandpaper feel, at sun-exposed areas
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Actinic Keratosis
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FOOSH, Radial fracture w/ dorsal displacement, dinner-fork deformity
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Colle’s Fx; Tx = volar splint
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Football player with burning pain, numbness, tingling from shoulder to hand which resolves
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Brachial plexus neurapraxia, “stinger”. Caused by stretching of brachial plexus
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Frothy, clear – white or yellow-green to gray adherent vaginal discharge, dysuria, vaginal pruritis. Vulvar and cervical erythema. Flagellated protozoa
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Trichomonas
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FTA-ABS, MTA-TP
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Syphilis diagnosis
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G6PD + Quinidine, Nitrofurantoin, Sulfa
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Hemolytic anemia
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Gangrene
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Clostridium infection – an anaerobic bacteria. Tx w/ hyperbaric oxygen, Penicillins, surgical excision
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Gastroparesis, impotence, recurrent infections, stocking-glove paresthesia
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Diabetic neuropathy (Treat w/ TCA (amitriptyline)
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Giant Multinucleated cells
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Herpes virus (Genital)
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Gram negative intracellular diplococcic
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Gonorrhea
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Gram stain
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Bacterial infections
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Granulomas and inflammation of alveoli, small bronchi and small blood vessels
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Sarcoidosis
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Gray pharyngeal pseudomembrane, rash, splenomegaly, supraclavicular LAD
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Diphtheria
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Greasy, foul smelling, floating stools. Pear-shaped flagellated protozoan w/ 2 “eyes”. Water, travel, camping history
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Giardia
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Grossly elevated blood pressure esp. w/ signs of EOD
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Malignant or Urgent HTN
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Ground glass appearance on CXR
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Asbestosis (shipbuilders, building demolition)
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Grouped vesicles on erythematous base
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Herpes virus
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H.pylori gastritis
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2antibiotics & PPI
|
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HA worse in AM w/ focal neuro deficits
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Brain Tumor (MC is glioma)
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HA, sinus pressure, yellow – green nasal discharge
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Sinusitis – CT is gold standard
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Hand injury after a punch
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Boxer’s fracture. Ulnar gutter w/ intrinsic plus positioning. ORIF if angulation > 40 degress
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Hard periumbilical nodule
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Sister mary Joseph nodule = indicates metastatic gastric and pancreatic cancers
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Head trauma, disoriented – lucent – coma
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Epidural Hematoma
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Healthy looking < 5yo with lace-like rash on both cheeks – red papules
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Erythema infectiosum “Slapped cheek”, “5th Dz”.
|
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Hearing loss or tinnitus w/ metabolic acidosis
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Aspirin OD
|
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Heart failure after URI
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Myocarditis
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Heart failure, LVH
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ACEI (improves survival, prevents development of heart failure Sx)
|
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Hematuria, purpuric rash following streptococcal infection
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Glomerulonephritis, HSP
|
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Hematuria, RBC casts, proteinuria
|
Glomerulonephritis
|
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Hemophilia A, Duchennes MD
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X-linked Recessive
|
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High fever (up to 105oF) x 5 days then rash. May have conjunctivitis, cracking, lip fissures
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Kawasaki’s Disease; look for cardiac complications (myocarditis, pericarditis, arteritis, aneurysms)
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High output heart failure
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Pregnancy, thyrotoxicosis, anemia, beriberi, paget’s disease
|
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Hilar mass on CXR
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Lung Ca
|
|
HLA-B27
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Ankylosing spondylitis, Reiter’s syndrome
|
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Holosystolic murmur @ LSB, may have ventricular hypertrophy
|
VSD
|
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Honey colored crusts on erythematous base around nose & mouth
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Impetigo. Tx = Mupirocin
|
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Horizontal Nystagmus, acute onset vertigo
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Peripheral lesion
|
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HTN not responsive to basic meds
|
Think secondary HTN most likely Renal artery stenosis (infrarenal artery).
|
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HTN not responsive to meds
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Renal artery stenosis (Infrarenal artery)
|
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HTN Tx w/ meds, cough or angioedema
|
ACEI is cause
|
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HTN w/ hypernatremia, hypokalemia
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Primary Aldosteronism
|
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Hx angina but no acute sx. EKG no acute changes.
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Do Exercise stress test
|
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Hx CHF on diuretic & digoxin
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Suspect dig toxicity (hypokalemia from diuretic = dig toxicity)
|
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Hx HTN, nephrotic syndrome, CRF or Renal insufficiency. Know CBC.
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Anemia
|
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Hx IBD, progressive RUQ pain, wt loss, F, jaundice & pruritis. Elevated bilrubin & alkaline phosphate. ERCP with bile duct stenosis, dilatation
|
Primary sclerosing cholangitis (diffuse intra- and extrahepatic duct sclerosing and dilatation)
|
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Hx URI the palpable purpuric rash to buttocks, posterior thighs
|
HSP (Hx post Strep A infection)
|
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Hyaline Casts
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Normal (may be present after febrile illness, strenuous exercise)
|
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Hyperinflation on CXR, tear drop heart
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Emphysema
|
|
Hyperpigmentation, hypoglycemia, orthostatic hypotension, hypotension not responsive to fluids, hypotension following an illness, trauma, or surgery
|
Addison’s disease, crisis (Low aldosterone; get Random or AM cortisol, ACTH stimulation test)
|
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Hypoglycemia despite glucose administration. Increased C-peptide
|
Insulinoma
|
|
Hypoglycemia in alcoholic
|
Give Thiamine before glucose to prevent Wernicke’s encephalopathy
|
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Hyponatremia w/ bizarre behavior.
|
Lithium toxicity
|
|
Hyponatremia, hyperkalemia
|
Acute adrenal insufficiency (Addison’s crisis)
|
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Hypopigmented lesions, white, scaly. Gets worse w/ tanning or sun exposure
|
Pityriasis Alba
|
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Incontinence with straining
|
Stress
|
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Increased BUN/Cr, low FeNa
|
Prerenal Failure (Azotemia)
|
|
Indirect immunofluorescent Ab, Weil-Felix rxn, complement
|
RMSF (Rickettsia rickettsia)
|
|
Infant or pediatric w/ grouped vesicles on thumb or “tapioca” vesicles on thumb
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Herpetic whitlow
|
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Infant w/ dyspnea, difficulty feeding. Holosystolic murmur @ LSB, 3rd ICS. LVH & RVH
|
VSD
|
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Infant w/ erythematous, scaly crusty lesions at vertex of scalp
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Cradle cap – seborrheic dermatitis (Tx in infants w/ baby shampoo, warm olive oil compress, mild Hydrocortisone cream; Adults – selenium sulfide shampoo)
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Infant w/ round face, large protruding tongue, dry skin, umbilical hernia, constipation, enlarged abdomen, poor feeding, delayed developmental milestones
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Congenital Hypothyroidism
|
|
Inflammation of glans
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Balanitis
|
|
Infrequent blinking, tremor, rigidity, bradykinesia, shuffling gait, masked facies
|
Parkinson’s
|
|
Inspiratory stridor
|
FB, viral croup (laryngotracheobronchitis)
|
|
Intense pruritis esp. PM. Burrow like lesions at wrists, elbows, hands, webs of fingers
|
Scabies
|
|
Introduce solid foods (cereal, fruits)
|
4 – 6 mo; after 6 mo add meat, eggs, starchy foods
|
|
Irregular irregular
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Atrial fibrillation; (if > 48 or chronic – anticoagulate)
|
|
Irritative voiding symptoms, Fever, chills, CVA tenderness
|
Pyelonephritis
|
|
Isolated elevated indirect bilirubin
|
Gilbert’s syndrome
|
|
IVDA w/ new murmur
|
Bacterial endocarditis (strep. Viridians)
|
|
JVD, Hypotension, muffled heart sounds
|
Pericardial effusion/tamponade (Beck’s triad)
|
|
Kidney & lung bleeding (hematuria, hemoptysis)
|
Goodpasteures
|
|
Knee injury during football game
|
ACL (look for description of lachman or drawer test)
|
|
KOH
|
Fungus, Candida; Hyphae & buds, spaghetti & meatballs
|
|
Large joint pain. Knees w/ medial joint space narrowing, osteophytes. No erythema or warmth.
|
Osteoarthritis. Acetaminophen #1 choice
|
|
Lateral displaced PMI, Canon “a” waves, Quincke’s pulse, Corrigan’s pulse, Austin flint murmur, deMusset’s sign, water
|
Aortic Regurgitation/Insufficiency: Quincke’s pulse (subungual capillar pulsation), Corrigan (rapid rise and fall), Austin filnt (low pitch middiastolic murmur at apex)
|
|
LE pain after long periods of standing. Dilated, tortuous, veins
|
Varicose veins. Tx w/ compression stockings
|
|
LE rubor, no hair, brittle nails, pallor on elevation, calf or LE pain esp. with walking short distances relieved with rest or at PM
|
Arterial insufficiency/PAD, Intermittent claudication (ABI best choice, ateriogram gold standard)
|
|
Lens shaped hemorrhage
|
Epidural Hematoma
|
|
Loss of central vision
|
Ipsilateral optic nerve lesion
|
|
Low output heart failure
|
Ischemic heart disease, HTN, dilated CM, valve disease, arrhythmia
|
|
LP w/ decreased glucose, increased protein
|
Bacterial meningitis
|
|
LP w/ decreased protein, very few neutrophils
|
syphilitic meningitis
|
|
Lung scan with perfusion defects
|
PE
|
|
Lytic lesions in the back or skull
|
Multiple myeloma
|
|
Magenta tongue
|
Riboflavin deficiency (B2)
|
|
Malaria prophylaxis
|
Chloroquine
|
|
Male w/ gynecomastia, diminished or delayed secondary sex characteristics, small firm testicles, long arms & legs (eunechoid body habitus)
|
Klinefelter Syndrome XXY. Low serum testosterone & infertility.
|
|
Male w/ low back pain, stiffness. Pain worse wakening, improve during day. Decreased ROM at spine. Plain films show sacroiliac abnormality. HLA-B27 positive
|
Ankylosing spondylitis; Tx = NSAIDs (Indomethacin)
|
|
Male, recurrent relapsing HA. Worsened w/ EtOH, Lacrimation, salivation, rhinorrhea
|
Cluster HA
|
|
Mechanical valve or prosthesis & Dental, GU, GI, or ortho procedure prophylaxis
|
Bacterial endocarditis (strep. Viridians) prevention
|
|
Meconium-stained amniotic fluids
|
Fetal distress
|
|
Meningitis & <2mo
|
Grp B Strep, E. coli (Tx < 1yo = Vanco + Rocephin)
|
|
Meningitis < 4yo
|
H. flu, Grp B strep, N. meningititis
|
|
Meningitis > 2yo, adults
|
Strep, N. meningititis
|
|
Meningitis and rash
|
Meningiococcal
|
|
Mousy urine
|
PKU
|
|
MRSA
|
“spider bite” appearing lesion that turns into abscess. Tx w/ Vanco +/- rifampin, gentamicin, linezolid
|
|
Mucosal or gingival bleeding, epistaxix, menorrhagia
|
Von Willebrand disease
|
|
Multiple or constant GI ulcer pain despite medications
|
Zollinger-Ellison Syndrome
|
|
Murmur & Hx rheumatic heart disease
|
Mitral stenosis #1, Tricuspid Stenosis #2
|
|
myelin fragments, ↑ IgG, oligoclonal bands (Pathognomonic); Lhermitte’s sign = electrical sensation down body w/ neck flexion
|
MS
|
|
N/V, epigastric abdominal pain, worse supine, caused by alcohol ingestion, or following fatty meals
|
Acute pancreatitis
|
|
Neonate w/ projectile vomiting. Olive sized mass.
|
Pyloric stenosis
|
|
Neurofibromatosis
|
Autosomal dominant
|
|
New murmur after MI (esp. if apical systolic)
|
Mitral regurgitation (caused by papillary muscle rupture)
|
|
Night blindness
|
Vit A deficiency
|
|
Non-pruritic, raised, warty brown-black plaques, stuck onto skin feel greasy
|
Seborrheic keratosis
|
|
Oliguria, hematuria, proteinuria following streptococcal infection
|
Acute glomeruloneprhitis
|
|
Osteomyelitis after stepping on nail wearing sandals or tennis shoes
|
Pseudomonas aeruginosa (foam padding in shoes)
|
|
Otitis media
|
Strep. Pneumonia, H. influenza, strep. Pyogenes, moraxella catarhallis
|
|
Overweight, irregular menstrual cycles (poss. Amenorrhea), elevated blood sugar, hirsutism
|
PCOS (stein-leventhal syndrome)
|
|
Pain after tx of fracture w/ cast
|
Compartment syndrome
|
|
Pain at base of thumb, distal radial styloid. Pain reproduced with ulnar deviation of clenched fist.
|
deQuervain’s tenosynovitis
|
|
Pain on plantar foot @ 2 – 3rd metatarsal. Associated w/ tight shoes, relieved by removing shoes. Palpable painful mass
|
Morton’s neuroma; Tx w/ NSAIDs, wide shoes, then steroid injections
|
|
Pain preceding vesicular rash in dermatomal pattern
|
Herpes Zoster (if involved eye = herpes keratitis. NO steroids. Get immediate ophthalmology referral)
|
|
Painful swelling of upper or lower eyelid
|
Hordeolum
|
|
Painless bony mass. Plain films = stalky or broad-based projection from bone surface
|
Osteochondroma
|
|
Painless hematuria, flank pain or mass
|
Renal cell Carcinoma
|
|
Painless LAD (us. Neck or axilla), LAD in orderly fashion; “B” signs + pruritis; splenomegaly; LN pain after drinking alcohol
|
Hodgkin’s lymphoma
|
|
Painless LAD us. Scattered. “B” signs
|
Non-Hodgkin’s lymphoma
|
|
Painless rectal bleeding in pediatrics
|
Meckel’s diverticulum
|
|
Painless rectal bleeding. Bulging perianal mass w/ straining
|
Internal hemorrhoids
|
|
Painless vision loss. History of HTN
|
CRVO (blood & Thunder, retinal hemorrhages)
|
|
Painless vision loss. History of TIA, palpitations, arrhythmia, carotid disease, embolic source
|
CRAO (pale retina, cherry red macula)
|
|
Painless, nontender nodule on upper or lower eyelid
|
Chalazion
|
|
Painless, yellow triangular nodule on conjunctivia
|
Pinguecula (more common on nasal side)
|
|
Pale, edematous, boggy turbinates
|
Allergic rhinitis
|
|
Paplitations, tremors, hyperventilation or respiratory alkalosis, numb or tingling mouth or extremities
|
Anxiety
|
|
Paralysis after Campylobacter enteritis
|
GBS
|
|
Pastia’s lines, positive ASO titer
|
Scarlet fever (Grp A Strep)
|
|
Patchy fibrosis on CXR
|
Farmers lung
|
|
Peaked T-waves
|
HyperKalemia
|
|
Pearly papule with umbilicated center
|
Molluscum contagiosum
|
|
Pediatric wheezing
|
lower respiratory FB, asthma
|
|
Pediatric with barking cough, stridor
|
viral croup (laryngotracheobronchitis); Tx w/ racemic epi and glucocorticosteroids if stridor at rest.
|
|
Pediatric with episodes of blank stares
|
Absence (petit-mal) seizures.
|
|
Pediatric with fever or Hx URI with encephalopathy, emesis, hyperactive reflexes, hepatomegaly, elevated liver enzymes
|
Reye’s syndrome from URI/post-flu or aspirin use
|
|
Pediatric with high fever then after fever macular rash over trunk and neck. (rash after defervesence)
|
Roseola infantum (Herpesvirus); Motrin, symptomatic treatment
|
|
Pediatric with Hx recurrent lung infections, pancreatitis, reproductive problems, FTT
|
Cystic fibrosis (Staph & Pseudomonal infections usually cause of death)
|
|
Pediatric with perianal pruritis esp. at PM. Positive cellophane tape test
|
Pruritis ani – Pinworms (enterobiasis). Tx is Mebendazole
|
|
Peds w/ leg pain after physical activity, abnormal heart sounds, unequal UE & LE pulses, rib notching
|
Coarctation of aorta
|
|
Pellagra
|
Niacin (4D’s dermatitis, diarrhea, dementia, death), bright red tongue
|
|
Pericarditis post open heart surgery
|
Dressler’s syndrome. Tx w/ ASA #1. Indomethacin or other NSAID OK.
|
|
Periods of excessive drinking, buying, spending
|
Manic phase of bipolar disorder
|
|
Peri-umbilical or flank ecchymosis
|
Acute pancreatitis (Cullen & Grey Turner’s Sign)
|
|
Philadelphia chromosome
|
CML
|
|
Photosensitive rash
|
TCN, Sulfa drugs
|
|
Photosensitivity, abd pain w/ neurologic dysfunction, erythema or skin fragility
|
Porphyria
|
|
PICA, Pregnant & fatigue, Menstruation. Cheilosis
|
Fe Deficiency Anemia
|
|
Pleural thickening on CXR
|
Mesothelioma
|
|
PNA & decreased mental status, poor dental hygiene, dentures, foul smelling sputum, bronchiectasis. Patchy infiltrates in dependant lung zones
|
Aspiration PNA
|
|
PNA & HIV+, AIDS, Immunocompromised. Sx out of proportion to exam. Diffuse interstitial & alveolar infiltrates
|
Pneumocystis jerovecii; TMP-SMX = Drug of choice
|
|
PNA from Nursing homes, chronic care facility. Purulent sputum
|
Staphylococcus aureus
|
|
PNA w/ DM, immunocompromised, EtOH. Currant color sputum.
|
Klebsiella
|
|
PNA w/ Smokers, COPD
|
H. influenza
|
|
PNA w/ Water, late summer, construction site. Diarrhea. Toxic looking
|
Legionella
|
|
Polyuria, polydipsia. Dilute urine, Hypernatremia
|
Diabetes insipidus
|
|
Poor sleeping, obese, daytime fatigue & drowsy, snoring, HTN, PM wakening
|
Obstructive sleep apnea
|
|
Positive osmotic fragility test
|
G6PD deficiency (hemolytic anemia w/ oxidative drugs – sulfa, nitrofurantoin, quinidine)
|
|
Post MI
|
Beta-blockers
|
|
Post thyroidectomy – electrolyte watch
|
Hypocalcemia
|
|
Post thyroidectomy – most likely injury
|
Recurrent laryngeal nerve = hoarseness
|
|
Postmenopausal adnexal mass
|
Ovarian Ca
|
|
Postmenopausal vaginal bleeding
|
Endometrial Ca – do endometrial biopsy
|
|
Postmenopausal, dyspareunia, thin vaginal discharge, atrophic vulvar changes, vaginal petechiae
|
Atrophic vaginitis; Tx = topical estrogen
|
|
Postpartum hemorrhage
|
Uterine Atony. Tx = uterine massage
|
|
Preemie CXR w/ hypoexpansion (ATX), air bronchograms
|
Hyaline Mb Disease
|
|
Pregnant
|
Nagel’s rule: LMP + 7 – 3 mo
|
|
Pregnant + rash, post-auricular or occipital LAD
|
Rubella. Give vaccine AFTER delivery
|
|
Pregnant < 20 wks gestation w/ vaginal bleeding, abd & pelvic pain. Blood from closed cervical os.
|
Threatened abortion
|
|
Pregnant < 20 wks gestation w/ vaginal bleeding, abd & pelvic pain. Tissue at or said to be passed from open cervical os.
|
Incomplete abortion (complete abortion will have empty uterus, complete passage of fetal tissue, pain resolves after passage of tissue)
|
|
Pregnant who drinks during pregnancy and inadequate peri-natal care
|
Fetal alcohol syndrome – low birth weight
|
|
Pregnant, HA, visual disturbance
|
Pre-eclampsia
|
|
Pregnant, seizures
|
Eclampsia
|
|
Premature birth, fetal maturity
|
Give corticosteroids
|
|
Premature infant with respiratory distress
|
Hyaline Mb Disease
|
|
Procainamide, hydralazine & rash
|
Lupus-type eruptions
|
|
Proximal symmetric muscle pain & stiffness esp. shoulder, neck, pelvic girdle
|
Polymyalgia rheumatica
|
|
Pruritic raised erythematous plaques
|
Urticaria
|
|
Pt on antipsychotic meds develops altered consciousness, lead-pipe rigidity, diaphoresis, catatonia. Hyperthermia, tachypnea, blood pressure changes.
|
Neuroleptic malignant syndrome. Tx supportive care & antipyretics
|
|
PUD, Pernicious anemia (Type A Gastritis), H. pylori
|
Gastric Ca
|
|
pulsus paradoxus
|
Pericardial effusion/tamponade, pericarditis, asthma attack, tension PTX, SVC obstruction
|
|
QT prolongation
|
Hypocalemia
|
|
Raccoons, bats, skunks
|
Rabies; give Ig, Rabies vaccine if animal is not caught and tested
|
|
Raised pearly-borders, telangiectasia, central ulcer
|
Basal cell Ca
|
|
Rapid onset of cognitive symptoms, mental status fluctuations, anxiety, irritability
|
Delerium
|
|
Rapid, deep labored breathing
|
Kussmaul breathing – DKA, Metabolic acidosis
|
|
Rat bite erosions on XR
|
Psoriatic arthritis
|
|
Raw red hands, chafed.
|
Obsessive compulsive disorder
|
|
RBC casts
|
Glomerulonephritis
|
|
Recurrent episodes of vision change, diplopia that resolve
|
MS
|
|
Recurrent episodes of vision change, diplopia, weakness & tingling in extremities that resolve
|
MS
|
|
Recurrent HA, HTN not responding to meds, sweating
|
Pheochromocytoma – Tx pre-op w/ alpha blocker
|
|
Recurrent kidney stones, elevated Calcium, decreased phosphorus
|
Hyperparathyroidism
|
|
Red cervix w/ mucopurulent discharge in sexually active female
|
Chlamydia
|
|
Red eye, copious purulent discharge
|
Gonococcal conjunctivitis
|
|
Red eye, hyperemia, chemosis, nodular conjunctivia
|
Allergic conjunctivitis
|
|
Red eye, watery discharge, preauricular LAD
|
Viral conjunctivitis
|
|
Red, less distinct borders. Coral red fluorescence under Wood’s lamp
|
Erythrasma
|
|
Reed-sternberg cells
|
Hodgkin’s lymphoma
|
|
Reticular to nodular pattern on CXR
|
Coal Miner’s lung
|
|
Retropatellar knee pain esp. in females
|
Patellorfemoral pain syndrome – increased Q angle, strengthen quadriceps
|
|
Rickets
|
Vit D (Osteomalacia)
|
|
s/p Fall w/ bilateral LE weakness, urinary and rectal incontinence, decreased rectal tone
|
Cauda equine syndrome = neurosurgical consult
|
|
s/p gastric bypass surgery or gastric surgery. N, abd cramping, dizziness after eating. No masses, bleeding
|
Dumping syndrome
|
|
s/p thoracic trauma. Multiple rib fractures. Chest wall moves in with inspiration, out with expiration.
|
Flail chest (pain control, incentive spirometry, pulmonary toilet, intubation)
|
|
S3
|
CHF, dilagted cardiomyopathy
|
|
Scabies & Pediatrics
|
NO LINDANE (KWELL). Permethrin (Elimite) is drug of choice
|
|
Scurvy
|
Vit C (easy bleeding, bruising, hair & tooth loss, joint pain & swelling)
|
|
Secondary amenorrhea
|
Pregnancy
|
|
Sensorineural loss > 50yo
|
Presbyacussis (Hi freq sounds 1st to go)
|
|
Sexually active person w/ rash on palms & soles, general LAD
|
Secondary syphilis (Money spots); VDRL will confirm
|
|
Sexually active, multiple or new partner, urethral discharge, Gram negative intracellular diplococci
|
Gonorrhea
|
|
Short lived, intense relationships. Difficulty controlling anger esp. when feeling abandoned. Hx sexual promiscuity and substance abuse.
|
Borderline personality disorder
|
|
Short PR, wide QRS, Delta wave
|
Wolf-parkinson-white; avoid Digoxin,
|
|
Shoulder pain after repetitive activity, point tenderness at anterior humerus or AC joint. + drop arm test or apprehension test
|
Rotator cuff injury (SITS muscles)
|
|
Sickle cell
|
Autosomal Recessive, pain in extremities after exercise, priaprism
|
|
Sickle cell, CF, PKU
|
Autosomal Recessive
|
|
Silvery scaling plaques on extensor sensors. Ausptiz sign, Koebner’s phenomena
|
Psoriasis
|
|
Small white papules on diffusely red base on buccal mucosa
|
Koplick spots – Rubeola (Measles). Spots occur before rash
|
|
Smoker, chronic productive cough. NO hemoptysis, wt. loss.
|
Brochitis (COPD)
|
|
Smoker, DOE, cough
|
COPD
|
|
Smoker, white mouth lesion cannot be rubbed off
|
Leukoplakia, rule out oral cancer
|
|
Sneezing, clear rhinorrhea, post-nasal drip, nasal congestion seasonal occurance
|
Allergic rhinitis. Nedocromil effective Tx.
|
|
Softened, tender, diffusely globular uterine enlargement
|
Adenomyosis
|
|
spaghetti & meatballs
|
Tinea (fungal infection
|
|
Splenectomy
|
Pneumococcal vaccine
|
|
Spontaneous bloody, serous, or cloudy nipple discharge
|
Intraductal papilloma
|
|
Spontaneous Hemarthrosis
|
Hemophilia A
|
|
Stab wound to chest. Hypotension, tracheal shift
|
Tension PTX
|
|
Stab wound, hyperresonance to percussion, decreased breath sounds, tympany
|
Pneumothorax
|
|
Steeple sign
|
FB, viral croup (laryngotracheobronchitis)
|
|
Stqb wound, dullness to percussion, decreased breath sounds.
|
Hemothorax
|
|
Strawberry tongue
|
Scarlet fever (Grp A Strep)
|
|
Sudden dizzy, N, V. NO tinnitus, hearing loss. Recent URI
|
Vestibular neuronitis, labrynthitis
|
|
Sudden dizzy, vertigo, hearing loss, tinnitus
|
Meniere’s disease; Treat w/ diuretics & low-sodium diet
|
|
Sudden onset ripping, tearing chest pain, diminished pulses
|
Aortic dissection
|
|
Sudden onset thunderclap HA, “worse HA of my life”
|
Subarachnoid hemorrhage
|
|
Sudden vertigo with changes in head position
|
BPPV
|
|
Superior contralateral quadrantopia
|
Temporal optic radiation
|
|
Supraclavicular LAD (L > R)
|
Virchow’s node – metastatic abdominal cancer
|
|
Sweat chloride test
|
Cystic fibrosis
|
|
Swimmer with ear pain, discharge
|
Otitis externa
|
|
Systolic ejection murmur heard best at base with radiation to left clavicle
|
Pulmonary stenosis
|
|
Systolic murmur heard best at apex with radiation to left axilla (apical systolic)
|
Mitral regurgitation
|
|
Tall, skinny, male, band student, acute onset one-sided chest pain, dyspnea
|
Spontaneous PTX
|
|
Target lesion, arthralgia, Bell’s Palsy
|
Lyme Dz (Borrelia Burgdorfi)
|
|
Teenage female with long bone pain without trauma or injury. XR w/ lytic mass, multi-laminated periosteal reaction
|
Ewing sarcoma – periosteal “onion skin” reaction
|
|
Temporal field loss
|
Ipsilateral optic tract lesion
|
|
Tetany, hypocalcemia, cataracts
|
Hypoparathyroidism
|
|
Thick white vaginal discharge, hyphae & buds on KOH prep
|
Candida
|
|
Thick, yellow, brittle nails
|
Onychomycosis. Tx = PO Terbinafine
|
|
Thumbprint sign
|
Epiglottitis
|
|
Tibial pain after running (military recruits), athletic activity (running sports)
|
Shin splints, stress fracture. Get bone scan if negative x-ray
|
|
Tinnitus and metabolic acidosis
|
Salicylate Ingestion
|
|
Transient monocular vision loss
|
Amaurosis fugax – TIA, emboli
|
|
Traveler’s Diarrhea
|
E. coli is cause. Hydration & Cipro to treat
|
|
Trendelenberg test of extremities
|
Tests for veinous insufficiency.
|
|
Truncal Rash in pediatric after fever
|
Roseola infantum (Herpesvirus); Motrin, symptomatic treatment
|
|
Tx of HTN w/ alpha-blocker
|
SE is postural Hypotension
|
|
Typing, secretary wrist pain and numb/tingling from wrist to hand. New mothers, pregnant may worsen
|
Carpal Tunnel syndrome
|
|
Tzank Smear
|
Herpes virus (Genital)
|
|
U waves
|
HypoKalemia
|
|
Unilateral facial weakness w/ inability to close eye
|
Bell’s palsy (self-limiting)
|
|
Unilateral foul smelling or purulent nasal discharge in a pediatric patient
|
Nasal Foreign body
|
|
Unilateral nerve deafness in middle age Pt
|
Acoustic neuroma (order MRI)
|
|
Urinary catecholamines, urinary metanephrines
|
Pheochromocytoma – Tx pre-op w/ alpha blocker
|
|
Venous stasis, vessel wall injury, hypercoagulability
|
DVT/PE (Virchow’s triad)
|
|
Vertical Nystagmus, insidious onset vertigo
|
Central lesion (tumor)
|
|
Viral Meningitis
|
Mumps
|
|
Vision loss over hours to days, painful EOM
|
Optic Neuritis (assoc. w/ MS)
|
|
Vit D – Rickets
|
X-linked dominant
|
|
Walks alone
|
15 mo
|
|
Warm, erythematous, tender skin with possible induration or fluctuance
|
Cellulitis
|
|
Weakness and fatigue in upper limbs, blurry vision, diplopia, respiratory distress
|
Myasthenia gravis
|
|
Weight loss, recurrent greasy stools (steatorrhea) mixed with diarrhea after certain foods
|
Celiac Sprue
|
|
Wheezing, prolonged expiration
|
Asthma
|
|
Wood’s light
|
Coral red = Erythrasma
|
|
Wood’s light fluoroscopy
|
Dermatophytes infections, Erythrasma (coral red)
|
|
Woods, forest, hikers. Macular rash at wrist, ankles then moves up extremities then trunk. After 5 days rash at palms & soles
|
RMSF (Rickettsia rickettsia)
|
|
Worsening fatigue, wt loss, weakness, recurrent abdominal pain, hair loss, hyperpigmentation. Hyponatremia, hyperkalemia
|
Addison’s disease, crisis (Low aldosterone; get Random or AM cortisol, ACTH stimulation test)
|
|
Wt. gain, edema, coarse dry skin, hair, menorrhagia, cold intolerance, hx transphenoidal surgery & radiation
|
Hypothyroidism
|
|
XXY ♂ - short stature, ↓ intelligence; small firm testes, gynecomastia, abn arm-body length
|
Klinefelters (hypogonadism)
|
|
Young athlete with syncope during athletic event or practice. No physical exam abnormalities
|
Hypertrophic CM or fatal arrhythmia. Get EKG or Echo
|
|
Young female (<30yo), palpitations, long arms & fingers, pectus excavatum, ectopic lentis, flexible joints
|
Marfan’s Syndrome – MVP, Aortic regurgitation, Aortic dissection, Aortic root dilatation, ectopic lentis
|
|
Young kid with difficulty standing from seated position. Calf muscle wasting
|
Muscular dystrophy (weakness begins at pelvic girdle)
|
|
Monoclonal spike on serum electrophoresis (M-protein)
|
Multiple myeloma
|
|
Smudge cells on peripheral smear
|
CLL
|
|
Palpable olive
|
Pyloric Stenosis
|
|
String sign (long narrow pyloric lumen)
|
Pyloric Stenosis
|
|
Bag of worms in scrotum
|
Varicocele
|
|
Boggy uterus
|
Adenomyosis
|
|
Steeple sx on x-ray
|
croup
|
|
Thumb sx on x-ray
|
epiglottitis
|
|
Cherry red spot (red fovea) on Fundoscopy
|
CRAO
|
|
Blood and Thunder retina
|
CR Vein occlusion
|
|
Rust-colored sputum
|
Strep. Pneumo PNA
|
|
Currant Jelly sputum
|
Klebsiella pneumo. PNA
|
|
Unilateral ptosis, anhidrosis, miosis
|
Horner's Syndrome
|
|
Parenchymal bullae or subpleural blebs
|
Emphysema (patho.)
|
|
ECG = S1Q3 inverted T3
|
cor pulmonale from PE
|
|
CXR honeycombing
|
pulmonary fibrosis or bronchiectasis
|
|
Lung bx = nonencaseating granulomas
|
Sarcoidosis
|
|
Hot potato voice
|
peritonsillar abscess
|
|
CXR visceral pleural line or "deep sulcus sign" on supine
|
PTX
|
|
Pharyngeal gray pseudomembrane
|
Diphtheria
|
|
Electrical alternans on ECG
|
cardiac effusion (patho.)
|
|
Osler nodes (pnful finger, toe, feet lesions), Janeway lesions (pnless palm and sole lesions), Roth spots (exudative retinal lesions/hemhorrages)
|
Infective Endocarditis
|
|
Bite cells (loss of Heinz body) on peripheral smear
|
G6PD deficiency
|
|
Heinz bodies on peripheral smear
|
G6PD def. or thalassemia
|
|
Beefy red tongue
|
pronounced anemia
|
|
Pica
|
Fe deficiency
|
|
Macro-ovalocytes and hypersegmented PMNs
|
Folate def. anemia (patho.)
|
|
Pancytopenia with circulating blasts
|
acute leukemia
|
|
Auer rods on peripheral smear (needle-like inclusions in eosinophiles)
|
AML (can also be ALL, but less likely)
|
|
Blast-crisis
|
CML
|
|
Reed-Sternberg Cells on LN bx
|
Hodgkin's Lymphoma
|
|
Rouleau Formation on peripheral smear
|
Multiple Myeloma
|
|
Bence Jones Proteins in urine
|
Muliple Myeloma
|
|
Parrot-beaked esophagus (dilated esophagus taper to the distal obstruction) on barium swallow
|
Achalasia
|
|
Cobblestone-pattern filling defects with segmental areas of involvement (skip lesions) on Barium enema or CT
|
Chron's Dz.
|
|
Currant Jelly stools
|
Intussusception
|
|
Sausage-like mass on abdominal exam
|
Intussusception
|
|
Chvostek's Sign (twitch facial nerve on tap)
|
Hypocalcemia
|
|
Trousseau's Sign (carpal tunnel spasm with BP cuff for 3 min.)
|
Hypocalcemia
|
|
Herberden's nodes (DIP nodes)
|
OA
|
|
Bouchard's nodes (PIP nodes)
|
OA
|
|
Swan neck deformity (flexed DIP, extended PIP, flexed MCP)
|
RA
|
|
Boutinniere deformity (extended DIP, flexed PIP)
|
RA
|
|
Subcutaneous nodules on extensor surfaces
|
RA (patho.)
|
|
Koebner's phenomenon (maculopapular rash elicited by scratching that appears in the evening)
|
Juvenile RA
|
|
Cup and Saucer appearance of proximal phalanx on x-ray
|
Psoriatic arthritis
|
|
Tinel's sign (percussion of volar wrist causes tingling)
|
Carpal Tunnel
|
|
Phalen's sign (wrist flexion for 1 min causes pain)
|
Carpal Tunnel
|
|
Fx of 5th MC neck
|
Boxer's fx
|
|
Distal radial fx with dorsal angulation
|
Colle's fx
|
|
Distal radial fx with volar angulation
|
Smith's fx
|
|
Sprain of ulnar collateral ligament of thumb
|
Gamekeeper's thumb
|
|
Anterior fat pad sign
|
hemarthrosis in radial head fx
|
|
Anatomical snuffbox pain
|
Scaphoid fx
|
|
Bamboo appearance on x-ray of spine
|
Ankylosing Spondylitis
|
|
Cresent sign of hip on x-ray
|
Avascular necrosis of hip
|
|
Posterior Fat pad sign
|
Radial Head fx
|
|
Amyloid plaques and neurofibrillary tangles
|
Alzheimer's
|
|
Battle sx
|
Basilar skull fx
|
|
WBC casts
|
pyelo. (or nephritis)
|
|
Hyaline casts
|
ARF (or normal in athletes)
|
|
Renal Tubular Epitheleal cell casts ("muddy brown casts")
|
ATN
|
|
RBC casts
|
glomerulonephritis
|
|
Positive Finkelstein (pain with fist ulnar deviation)
|
DeQuervain's
|
|
Pedunculated bone mass capped in cartilage
|
Osteochondroma
|
|
Gottron's sx (scaly, papule rash on dorsal hands)
|
Dermatomyositis
|
|
Heliotrope rash (eyelid erythema)
|
Dermatomyositis (or SLE)
|
|
Low morning cortisol with elevated ACTH
|
Addison's disease
|
|
More than 125 mg/dL urine cortisol in 24 hours
|
Cushings
|
|
Milkman lines or Looser zones (pseudofractures)
|
Osteomalacia
|
|
Eruptive and tendious xanthomas
|
Hyperlipidemia (patho.)
|
|
Petechial rash with meningeal sxs
|
Neisseria Meningitidis
|
|
KOH hyphae and spores ("spaghetti and meatballs")
|
Tinea versicolor
|
|
S-shaped burrows on skin
|
Scabies
|
|
Snowstorm on TVU with elevated BHcg
|
Hydatidiform mole
|
|
Rope-like on CBE
|
Fibrocystic breasts
|
|
Herald patch then "Christamas tree" appearing rash
|
Pityrasis Rosea
|
|
Oncholysis with oil spots
|
Psoriasis (patho.)
|
|
Hot tub folliculitis
|
Pseudomonas aureginosa
|
|
Terry's nails (white nail bed)
|
Liver disease/cirrhosis
|
|
Azure (blue) lunulae on nails
|
Wilson's disease
|
|
Absent or decreased femoral pulses with a murmur
|
Coarctation of the aorta (patho.)
|
|
Kayser-Fleischer rings (brown rings btw iris and cornea)
|
Wilson's Disease
|
|
Boot-shaped heart
|
RVH from Tet. Of Fallot
|
|
Egg on a string (narrow mediastinum)
|
Transposition of Great Vessels
|
|
Lower BP in arms vs legs
|
Coarct. Aorta
|
|
Barking cough like a seal
|
Croup
|
|
Figure 3 sign on CXR
|
Coarct. Aorta
|
|
Machine-like murmur
|
Patent Ductus Arteriosis
|
|
Absence of "Scottie-Dog" sign on spinal film
|
Spondyloysis
|
|
Inability to pass NGT in an infant
|
Choanal Atresia
|
|
Palpable, non-tender gallbladder (Courvoisier's sign)
|
Pancreatic CA
|
|
Charcot's triad (fever, chills, RUQ pain, jaundice)
|
Ascending Cholangitis
|
|
Bird beak deformity on x-ray
|
Achalasia or Sigmoid Volvulus
|
|
Apple-core lesion on Barium Enema
|
Colon CA
|
|
Lead pipe deformity (loss of normal haustral markings) on Barium Enema
|
UC
|
|
Clue cells on wet-prep and positive Whiff test (amine odor)
|
BV (Gardnerella vaginalis)
|
|
Strawberry Cervix
|
Trichomonas
|
|
Hyphae and buds on KOH Prep
|
Vaginal Candidiasis
|
|
String sign/ Sign of Kantor (Stricture or Stenosis) on Barium Enema
|
Chron's disease
|
|
Chandelier Sign on pelvic/speculum exam (cervical motion tenderness)
|
PID
|
|
Koplik spots-grains of sand on an erythematous base (Blue-White buccal lesions)
|
Measles/Rubeola (patho.)
|
|
Sandpaper rash (like sunburn with goosebumps)
|
Scarlet Fever
|
|
Strawberry tongue
|
Scarlet Fever
|
|
Honey golden crusts on face
|
Impetigo (Streptococcus Pyoderma)
|
|
Gram-positive, encapsulated, box-shaped rods in chains
|
Cutaneous Anthrax
|
|
Rice-water diarrhea (gray, turbid, and without odor, blood, or pus)
|
Cholera
|
|
Pea-soup Diarrhea
|
Enteric/Typhoid fever
|
|
Hyperplastic prickle cells with excess keratin
|
HPV skin warts
|
|
Koilocytotic squamous cells or vacuolated Squamous epithelial cells in clumps on Pap
|
HPV cervical warts
|
|
Multinucleated giant cells on Tzanck Smear
|
Herpes Simplex Virus
|
|
Intracytoplasmic inclusions ("owl's eyes") on tissue biopsy
|
CMV
|
|
Pizza pie (neovascularization with profliferation) on Fund
|
CMV
|
|
Satellite lesions on buttocks
|
Diaper dermatitis with candida
|
|
Bull's eye skin lesion
|
Erythema Migrans from Lyme Dz.
|
|
String of Pearls on ovarian US
|
PCOS
|
|
Sack of grapes or "grape-like vesicles" on TVU
|
Complete Hydatidiform Mole
|
|
5 Ps (purple, planar, polygonal, pruritic papule)
|
Lichen Planus
|
|
Lesions that have white lines (Wickham's striae)
|
Lichen Planus
|
|
Slapped cheek syndrome
|
Parvovirus B19/ Fifth's Dz/ Erythema Infecticosum
|
|
11:22
|
transloc seen in ewing sarcoma
|
|
11-hydroxylase deficiency
|
virilism, no cortisol, salt retention, HTN
|
|
14:18
|
follicular lymphoma IG heavy chain on 14, bcl-2 oncogene on 18
|
|
15:17
|
acute promyelocytic leukemia PML gene on 15 and RARa on 17
|
|
8:14
|
Burkitts c::myc is on 8, IG heavy chain is on 14
|
|
9:22
|
Philadelphia chromosome, CML bcr abl fusion c-abl on 9, bcr on 22
|
|
Actinic keratosis
|
Often precedes SCC
|
|
Addison’s disease
|
1° adrenocortical deficiency
|
|
Addisonian Anemia
|
pernicious anemia (antibodies to intrinsic factor or parietal cells ? ?IF ? ?Vit B12 ? megaloblastic anemia)
|
|
Adhesive arachnoiditis
|
Caused by bacterial meningitis, leads to obstructive hydrocephalus
|
|
AFP decrease
|
Down’s
|
|
AFP in amniotic fluid or mother’s serum
|
Spina Bifida; Anencephaly
|
|
AFP increase
|
Neural tube defects, hepatocellular carcinoma, yolk sac and embryonal carcinoma
|
|
Albers SCHonberg dx
|
aka osteopetrosis, marble bone dx, dense skeleton, failure of osteoclastic activity
|
|
Albright’s syndrome
|
Polyostotic fibrous dysplasia, precocious puberty, café-au-lait spots, short stature, young girls
|
|
Albuminocytologic dissociation
|
Guillain-Barré (↑ protein in CSF with only modest ↑ in cell count)
|
|
Alport’s Syndrome
|
hereditary nephritis with nerve deafness, Type 4 collagen defect (basement membranes)
|
|
Alzheimer’s
|
progressive dementia; tau proteins, neurofibrillary tangles, apolipoprotein E4 allele, narrow gyri and wide sulci (atrophy), occipital sparing, hydrocephalus ex vacuo, plaques in hippocampus and cortex, ? Acetylcholine, Hiramo bodies (inrtacellular inclusion bodies in hippocampal cells)
|
|
Amnion nodosum
|
Renal agenesis
|
|
Amyloid in thyroid
|
Thyroid medullary carcinoma (calcitonin)
|
|
Analgesic abuse
|
Papillary necrosis, esp. in diabetics
|
|
ANAs in SLE
|
dsDNA antibodies and Sm Smith antigen
|
|
Anasarca
|
Minimal change disease
|
|
Aneurysmal nodules
|
Polyarteritis nodosa
|
|
Angelman syndrome
|
materal transmission del(15)(q11q13), aka happy puppet syndrome, mental retardation, ataxia, seizures, inappropriate laughter
|
|
Angiomyolipoma
|
Tuberous sclerosis
|
|
Anosmia
|
Kallman’s syndrome
|
|
Anterior vermian atrophy
|
alcoholism
|
|
Anti–basement membrane antibodies
|
Goodpasture’s syndrome
|
|
Anti-centromere antibody
|
Limited scleroderma (CREST)
|
|
Anti-DNA topoisomerase antibody
|
Diffuse scleroderma
|
|
Anti-double-stranded DNA antibodies (ANA antibodies)
|
SLE (type III hypersensitivity)
|
|
Anti-endomysial antibody
|
Celiac sprue
|
|
Anti–epithelial cell antibodies
|
Pemphigus vulgaris
|
|
Antigliadin antibodies
|
Celiac disease
|
|
Antihistone antibodies
|
Drug-induced SLE
|
|
Anti-IgG antibodies
|
Rheumatoid arthritis
|
|
Anti-jo antibody
|
polymyositis
|
|
Anti-mitochondrial antibody
|
1° biliary cirrhosis
|
|
Antineutrophil antibodies
|
Vasculitis
|
|
Antiplatelet antibodies
|
Idiopathic thrombocytopenic purpura
|
|
Anti-sacharommyces cervisiae antibody
|
Crohn’s
|
|
Anti-Smith antibodies
|
Specific for SLE, anti-ribonulceoprotein
|
|
Anti-smooth muscle antibody
|
Autoimmune hepatitis type I
|
|
APC
|
tumor suppressor common in familial polyposis coli and adenoCA of colon as well as other tumors
|
|
Arachnodactyly
|
Marfan’s syndrome
|
|
Argyll-Robertson Pupil
|
loss of light reflex constriction (contralateral or bilateral), “Prostitute’s Eye” -accommodates but does not react, Pathognomonic for 3° Syphilis
|
|
Arnold Chiari formation
|
downward displacement of cerebellar tonsils and medulla through foramen magnum
|
|
Arthus reaction
|
seen in hyperacute rejection,
|
|
Aschoff body
|
Rheumatic fever; area of focal interstitial myocardial inflammation characterized by fragmented collagen and fibrinoid material, by large cells (Anitschkow myocytes) and occasional multinucleated giant cells (Aschoff cells)
|
|
Ashleaf spots (skin)
|
Tuberous sclerosis
|
|
Atrophy of the mammillary bodies
|
Wernicke’s encephalopathy
|
|
Atypical lymphocytes
|
EBV
|
|
Auer rods
|
Acute myelogenous leukemia (especially the promyelocytic type; (AML type M3))
|
|
Autosplenectomy
|
Sickle cell anemia
|
|
Babinski’s sign
|
UMN lesion
|
|
Bacterial conjunctivitis
|
S. aureus, strep. pneumo, Hemophilus aegyptius
|
|
Baker’s cyst in popliteal fossa
|
Rheumatoid arthritis
|
|
Bamboo spine” on x-ray
|
Ankylosing spondylitis
|
|
Barrett’s
|
columnar metaplasia of lower esophagus (* risk of adenocarcinoma)
|
|
Bartter’s Syndrome
|
hyperreninemia
|
|
Basophilic stippling of RBCs
|
Lead poisoning
|
|
Bax
|
gene product facilitates apoptosis
|
|
Bcl2
|
gene product inhibits apoptosis
|
|
Becker’s muscular dystrophy
|
Defective dystrophin; less severe than Duchenne’s
|
|
Beckwith Weidemann syndrome
|
hemihypertrophy, macroglossia, organomegaly, neonatal hypoglycemia, various embryonal tumors, deleted WT 2 gene
|
|
Bell’s Palsy
|
CNVII palsy (entire face; recall that UMN lesion only affects lower face)
|
|
Bence Jones proteins
|
Multiple myeloma (kappa or lambda Ig light chains in urine), Waldenström’s macroglobulinemia (IgM)
|
|
Berger dx
|
aka IgA nephropathy, deposition of IgA in mesangium, benign recurrent hematuria in kids following infection
|
|
Beriberi
|
this comes in a wet variety and a dry one, they are both Vit B1 thiamine deficiency
|
|
Bernard-Soulier Disease
|
defect in platelet adhesion (abnormally large platelets & lack of platelet-surface glycoprotein ["GPIb IX V"]) autosomal recessive
|
|
Berry Aneurysm
|
circle of Willis (subarachnoid bleed), often associated with ADPKD
|
|
Bilateral breast cancer
|
Lobular carcinoma
|
|
Bilateral hilar adenopathy, uveitis
|
Sarcoidosis
|
|
Bilateral renal cell carcinoma
|
Von Hippel-Lindau
|
|
Binswanger dx
|
aka subcortical leukoencephalopathy, assoc with HTN, multiple lacunar infarcts and progressive demyelination in subcortical area
|
|
Birbeck granules on EM
|
Histiocytosis X (eosinophilic granuloma); tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)
|
|
Bladder trabeculation
|
BPH
|
|
Bloody nipple discharge
|
Intraductal papilloma
|
|
Bloody tap on LP
|
Subarachnoid hemorrhage
|
|
Blue bloater”
|
Chronic bronchitis
|
|
Blue sclera
|
Osteogenesis imperfecta
|
|
Blueberry muffin baby
|
Rubella
|
|
Blue-domed cysts
|
Fibrocystic change of the breast
|
|
Boot-shaped heart on x-ray
|
Tetralogy of Fallot; RVH
|
|
Bouchard’s nodes
|
Osteoarthritis (PIP swelling 2° to osteophytes)
|
|
Boutonnière deformity
|
Rheumatoid arthritis
|
|
Bowen’s Disease
|
carcinoma in situ on shaft of penis (* risk of visceral ca)
|
|
Bowenoid papulosis
|
appears as multiple wart-like lesions resembling condyloma accuminatum
|
|
Branching rods in oral infection
|
Actinomyces israelii
|
|
BRCA1
|
tumor suppressor mutated in breast and ovary CA
|
|
BRCA2
|
associated with breast alone (isn't one of these associated with prostate? Check)
|
|
Brenner tumor
|
ovarian tumor resembling bladder transitional epith
|
|
Briquet’s Syndrome
|
somatization disorder
|
|
Broca’s Aphasia
|
Motor Aphasia intact comprehension
|
|
Bronchiolitis
|
RSV
|
|
Bronze Diabetes
|
Hemochromatosis
|
|
Brown tumor” of bone
|
Hemorrhage causes brown color of osteolytic cysts
|
|
Brown-Sequard
|
hemisection of cord (contralateral loss of pain & temp / ipsilateral loss of fine touch, UMN)
|
|
Brudzinski sign
|
meningitis
|
|
Brushfield spots
|
seen in Down synd, small white spots on periphery of iris
|
|
Brutons Agammaglobulinemia
|
x linked, absence of plasma cells and serum immunoglobulins, cell mediated immunity still ok, no germinal centers, recurrent bacterial infections, resistances to fungal and viral still, btk gene defect
|
|
Btk gene
|
defective in x-linked brutons agammaglobulinemia, B-cell tyrosine kinase
|
|
Budd Chiari
|
Posthepatic venous thrombosis; thrombotic occlusion of major hepatic veins, abnormal pain, jaundice, hepatomegaly, acites, liver failure, assoc with polycythemia vera, hepatocellular CA, and other common neoplasms, may occur as a complication of pregnancy
|
|
Buerger’s Disease
|
aka thromboangiitis obliterans, young jewish men, worse with smoking, acute inflammation of small, medium arteries * painful ischemia * gangrene
|
|
Burkitt’s Lymphoma
|
aggressive B-cell lymphoma, starry sky appearance, small noncleaved cell lymphoma EBV, 8
|
|
Burton’s lines
|
Lead poisoning
|
|
Café-au-lait spots on skin
|
Neurofibromatosis
|
|
Caisson disease
|
Gas emboli
|
|
Calf pseudohypertrophy
|
Duchenne’s muscular dystrophy
|
|
Call-Exner bodies
|
Granulosa-theca cell tumor of the ovary, small follicles filled with eosinophilic secretion, diagnostic feature of granulose cell tumor
|
|
C-ANCA, P-ANCA
|
Wegener’s granulomatosis, polyarteritis nodosa
|
|
Carbon monoxide poisoning
|
hyperemia, edema and necrosis of globus
|
|
Cardiomegaly with apical atrophy
|
Chagas’ disease
|
|
Carpal Tunnel Syndrome
|
Median nerve entrapment
|
|
Central Nuclei in Muscle
|
Muscular dystrophies
|
|
Cerebriform nuclei
|
Mycosis fungoides (cutaneous T-cell lymphoma)
|
|
Chagas’ Disease
|
Trypansoma infection sleeping disease, cardiomegaly with apical atrophy, megaesophagus, megacolon
|
|
Chancre
|
ulcer, 1° syphilis (not painful)
|
|
Chancroid
|
Haemophilus ducreyi, painful soft ulcers
|
|
Charcot Bouchard aneurysm
|
aneurysm at small artery bifurcations
|
|
Charcot’s triad
|
Multiple sclerosis (nystagmus, intention tremor, scanning speech), cholangitis (jaundice, RUQ pain, fever)
|
|
Charcot-Leyden crystals
|
Bronchial asthma (eosinophil membranes)
|
|
Chediak-Higashi Disease
|
Phagocyte Deficiency
|
|
Cherry-red spot on macula
|
Tay-Sachs, 50% of Niemann-Pick disease, central retinal artery occlusion
|
|
Cheyne-Stokes respirations
|
Central apnea in CHF and ↑ intracranial pressure
|
|
Chocolate cysts”
|
Endometriosis (frequently involves both ovaries)
|
|
Cholesterol clefts
|
atherosclerosis
|
|
Chordae tendinae short and fused
|
Rheumatic heart disease
|
|
Chromosome 10
|
paracentric inversion or translocation with 17 associated with papillary thyroid CA
|
|
Chronic atrophic gastritis
|
Predisposition to gastric carcinoma
|
|
Chronic staph infections
|
Chronic granulomatous disease, a deficiency of NADPH oxidase, can’t kill catalase positive bugs
|
|
Churg Strauss syndrome
|
aka allergic granulomatous angiitis, necrotizing vasculitis, variant of polyarteritis nodosa, involves pulmonary vasculature, peripheral eosinophilia, and asthma
|
|
Chvostek’s sign
|
Hypocalcemia (facial muscle spasm/tetany upon tapping)
|
|
Clear cell adenocarcinoma of
|
DES exposure in utero
|
|
Clear nuclei
|
Thyroid papillary carcinoma (Orphan Annie’s eyes)
|
|
Clue cell
|
Bacterial Vaginitis w/ Gardnerella vaginosis, vaginal epithelial cell with stippled appearance due to adherent coccobacilli
|
|
Codman’s triangle on x-ray
|
Osteosarcoma, periostium in bone tumors
|
|
Coin Lesions in Lung
|
Pulmonary Hamartoma
|
|
Cold agglutinins
|
Mycoplasma pneumoniae, infectious mononucleosis
|
|
Cold intolerance
|
Hypothyroidism
|
|
Cold thyroid nodules
|
Colloid cyst or thyroid adenoma
|
|
Concentric laminar intimal fibrosis of small arteries of lung
|
1° pulmonary HTN
|
|
Condylomata lata
|
2° syphilis
|
|
Congenital adrenal hyperplasia
|
21-hydroxylase deficiency
|
|
Congenital Hepatic Fibrosis
|
Polycystic Kidney Disease, juvenile autosomal recessive form
|
|
Conn’s Syndrome
|
1° aldosteronism
|
|
Continuous machinery murmur
|
Patent ductus arteriosus
|
|
Contraction Band Necrosis
|
MI
|
|
Cori’s Disease
|
glycogen storage disease (debranching enzyme deficiency), stunted growth, hepatomegaly, hypoglycemia
|
|
Cotton-wool spots
|
Chronic HTN
|
|
Cough, conjunctivitis, coryza
|
Measles
|
|
Councilman bodies
|
Toxic or viral hepatitis (dying hepatocytes); small round eosinophilic masses found in dying hepatocytes often containing chromatin remnants
|
|
Cowdry type A bodies
|
Herpesvirus
|
|
Crescents In Bowman’s Capsule
|
rapidly progressive (crescentic glomerulonephritis)
|
|
Creutzfeldt-Jakob
|
prion infection * cerebellar & cerebral degeneration
|
|
Cri du chat syndrome
|
5p chromosome deletion, severe mental retardation, microcephaly, catlike cry, low birth weight, round face, hypertelorism (wide eyes)
|
|
Crigler-Najjar Syndrome
|
congenital hyperbilirubinemia (unconjugated); due to deficient glucuronyl transferase
|
|
Crohn’s
|
IBD; ileocecum, transmural, skip lesions, lymphocytic infiltrate, granulomas, (contrast to UC
|
|
Croup
|
Parainfluenza
|
|
Crushed ping pong balls
|
Pneumocystis carinii
|
|
Crypt abscesses
|
Ulcerative colitis
|
|
Curling’s ulcer
|
Acute gastric ulcer associated with severe burns
|
|
Currant-jelly sputum
|
Klebsiella
|
|
Curschmann’s spirals
|
Bronchial asthma (whorled mucous plugs)
|
|
Cushing’s
|
Disease
|
|
Cushing’s ulcer
|
Acute gastric ulcer associated with CNS injury
|
|
Cystathioine synthase deficieny
|
homocystinuria
|
|
D-dimers
|
DIC
|
|
de Quervain’s Thyroiditis
|
self-limiting focal destruction (subacute thyroiditis)
|
|
Denys Drash syndrome
|
abnormal WT 1 gene, intersexual disorders, nephropathy, wilms tumor
|
|
Depigmentation of neurons in substantia nigra
|
Parkinson’s disease (basal ganglia disorder––rigidity, resting tremor, bradykinesia)
|
|
Dermatitis, dementia, diarrhea
|
Pellagra (niacin, vitamin B3 deficiency)
|
|
Dew drop on rose petal
|
Chicken pox
|
|
Diabetes insipidus + exophthalmos + ?
|
Hand-Schüller-Christian disease
|
|
Diaphragmatic pleural plaques
|
Asbestosis
|
|
DiGeorge’s Syndrome
|
thymic hypoplasia, T-cell deficiency; aka velocardiofacial syndrome and CATCH 22 syndrome, micro deletion of 22q11, Cardiac abnormalities, Abnormal facies, Cleft palate, Hypocalcemia due to hypoparathyroidism, from poor development of 3rd and 4th cranial arches
|
|
Dog or cat bite
|
Pasteurella multocida
|
|
Donovan bodies
|
seen in granuloma inguinale (STD), multiple organisms filling large histiocytes
|
|
dopamine receptors
|
Parkinson’s & schizophrenia
|
|
Double bubble sign on ultrasound
|
Down’s syndrome – duodenal atresia
|
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Down’s Syndrome
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trisomy 21 or translocation
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Dressler’s Syndrome
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Post-MI Fibrinous Pericarditis autoimmune
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Dry beriberi
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peripheral neuropathy, atrophy of muscles, wet - high output cardiac failure, DCM, AV shunting, hypervolemia
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Dubin-Johnson Syndrome
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congenital hyperbilirubinemia (conjugated), striking brown-to-black discoloration of the liver; autosomal recessive, defect in bili transport
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Duchenne Muscular Dystrophy
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deficiency of dystrophin protein * MD X-linked recessive
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Duret Hemorrhages
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Uncal herniation
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E4 allele of apoprotein E
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chromosome 19, allele common in alzheimers
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Eburnation
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Osteoarthritis (polished, ivory-like appearance of bone)
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Eccentric intimal fibrosis with medial hypertrophy
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Chronic transplant rejection
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Ectopia Lentis
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Marfan’s
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Edwards’ Syndrome
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trisomy 18, rocker-bottom feet, low ears, heart disease, mental retardation, prominent occiput, micrognathia (small jaw), finger deformities
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Ehler’s-Danlos
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defective collagen
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Eisenmenger’s Complex
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late cyanotic shunt (R→L) pulmonary HTN & RVH 2° to long-standing VSD, ASD, or PDA
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Elastic skin
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Ehlers-Danlos syndrome
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Embolizing endocarditis
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Infectious, marantic (fibrin deposits in hypercoagulable states)
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Erb-Duchenne palsy
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Superior trunk brachial plexus injury (“waiter’s tip”)
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Erythema chronicum migrans
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Lyme disease
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Ewing Sarcoma
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undifferentiated round cell tumor of long bone; kids, "onion skin" type periosteal reaction, 11:22 transloc
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Excavation of Optic Cup
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Glaucoma
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Exopthalmos
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hyperthyroid
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Eyrthroplasia of Queyrat
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carcinoma in situ on glans penis
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Fabry dx
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aka angiokeratoma corporis diffusum universal, deficient a::galactosidase A, accumulate ceramide trihexoside, skin lesions angiokeratomas, fever, burning pain in extremities, cardiovascular and cerebrovascular involvement, death as adult by renal failure p59
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False positive VDRL
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SLE, Treponema pertenue (non-STD tropical infection)
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Fanconi’s Syndrome
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impaired proximal tubular reabsorption 2* to lead poisoning or Tetracycline (glycosuria, hyperphosphaturia, aminoaciduria, systemic acidosis)
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FAT RN
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TTP (fever, anemia, thrombocytopenia, renal failure, neuro problems)
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Fat, female, forty, and fertile”
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Acute cholecystitis
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Fatty liver
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Alcoholism
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Fecalith
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Acute appendicitis
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Felty’s Syndrome
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rheumatoid arthritis, neutropenia, splenomegaly
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Ferruginous body
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asbestosis, yellow-brown, rod shaped body with clubbed ends, stain with Prussian blue
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FEV1/FVC ↓
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COPD (< 70%)
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FGFR3
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gene mutated in achondroplasia (most common form of dwarfism),
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Fish-mouthed mitral valve
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Rheumatic heart disease
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Flea-bitten Kidney
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Malignant HTN
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Foamy histiocyte
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sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver, spleen, lymph nodes and skin
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Frontal bossing
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Sickle cell anemia
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Fungus ball in lung
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Apergillus
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galactosemia
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Galactose-1-phosphate uridyl transferase deficiency or galactokinase deficiency
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Gardner’s Syndrome
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adenomatous polyps of colon plus osteomas & soft tissue tumors; autosomal dominant
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Garlic odor on breath
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Arsenic (or lasagna)
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Gaucher’s Disease
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Lysosomal Storage Disease glucocerebrosidase deficiency, hepatosplenomegaly, femoral head & long bone erosion, anemia
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Gerstmann Straussler
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Scheinker syndrome :
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Ghon focus/complex
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1° TB
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Gilbert’s Syndrome
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benign congenital hyperbilirubinemia (unconjugated); modest elevated serum unconj bilirubin, due to decreased uptake by liver cells and reduced activity of glucuronyl transferase
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GIST
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Tumor arising in cells of Cajal (pacemakers of gut)
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Glanzmann’s thrombasthenia
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Defect (glycoprotein) in platelet aggregation
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glucose, protein in CSF
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Bacterial meningitis
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GNAS1
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mutation here causes pseudohypoparathyroidism
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Gold Pneumonia
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Lipid pneumonia, exogenous (aspiration) or endogenous (obstruction
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Goodpasture’s
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autoimmune
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Gowers’ maneuver
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Duchenne’s (use of patient’s arms to help legs pick self off the floor)
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Graves Dz
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autoimmune thyroiditis, hyperthyroid, exophthalmos, increased in HLA DR3 and HLA B8 pos people
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Gray discoloration of skin
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Argyria (silver poisoning)
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Guillain-Barre
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idiopathic polyneuritis; acute inflammatory demyelinating Dz primarily involving peripheral nerves (ascending muscle weakness & paralysis; usually self-limiting)
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H shaped vertebrae
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Sickle cell anemia
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Hair-on-end” appearance on x-ray
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β-thalassemia, sickle cell anemia (extramedullary hematopoiesis)
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Hamman-Rich Syndrome
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idiopathic pulmonary fibrosis
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Hand Schuller Christian Dz
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aka chronic progressive histiocytosis, not as bad as Letterer Siwe
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Hartnup dx
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impaired tubular reabsorption of tryptophan, pellagra::like manifestations
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Hashimoto’s Thyroiditis
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autoimmune hypothyroidism (antimicrosomal or antithyroglobulin); Hurthle cells, thyroid germinal centers,
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Hashitoxicosis
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initial hyperthyroidism in Hashimoto’s Thyroiditis that precedes hypothyroidism
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Hat size increase
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Paget’s disease of bone
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HbF
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Thalassemia major
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HbS
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Sickle cell anemia
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hCG elevated
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Choriocarcinoma, hydatidiform mole (occurs with and without embryo)
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Heart failure cells
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intra::alveolar hemosiderin-laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN
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Heberden’s nodes
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Osteoarthritis (DIP swelling 2° to osteophytes)
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Heinz bodies
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G6PD deficiency
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Hemarthrosis
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Coagulation factor deficiency
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Hemorrhagic Temporal Lobe Lesion
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HSV
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Hemorrhagic Urticaria
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Henoch-Schonlein
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Henoch-Schönlein purpura
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Hypersensitivity vasculitis; hemorrhagic urticaria of extensor surfaces of arms, legs, and buttocks, with fever, arthralgias, and GI renal involvement similar to IgA nephropathy, associated with URIs
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HER
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2/neu :
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Hereditary Spherocytosis
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RBC cytoskeletin defect, most commonly spectrin
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Heterophil antibodies
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Infectious mononucleosis (EBV)
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Hfe gene
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located on xsome 6, mutation here
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High-output cardiac failure (dilated cardiomyopathy)
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Wet beriberi (thiamine, vitamin B1 deficiency)
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Hirano bodies
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intracytoplasmic proximal dentritic eosinophilic inclusions consisting of actin seen in Alzheimers
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Hirschsprung Dz
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aka congenital agnaglionic megacolon, dilation of colon due to absence of ganglion cells
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HLA B27
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Ankylosing spondylitis (90%), psoriasis, IBD, Reiter’s syndrome
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HLA-DR3 or -DR4
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Diabetes mellitus type 1 (caused by autoimmune destruction of β cells)
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Hodgkin dx
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malignant lymphoma with features resembling inflammatory disorder, young men, Reed Sternburg cells
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Homer Wright rosettes
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Neuroblastoma
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Honeycomb lung on x-ray
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Interstitial fibrosis
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Horner’s Syndrome
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ptosis, miosis, anhidrosis (lesion of cervical sympathetic nerves often 2* to a Pancoast tumor)
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Howell Jolley Bodies
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Splenectomy, remnant of nuclear DNA
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HTN + hypokalemia
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Conn’s syndrome
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Human placental lactogen increase
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Placental site trophoblastic tumor
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Hunter syndrome
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similar to Hurler, deficient L iduronosulfate sulfatase, accumulations of heparin sulfate and dermatan sulfate, hepatospenomegaly, micrognathia, retinal degeneration, joint stiffness, mental retardation, cardiac lesions
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Huntington’s
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progressive degeneration of caudate nucleus, putamen & frontal cortex with neuronal depletion and gliosis; (autosomal dominant); fatal
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Hurler syndrome
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mucopolysaccharidosis, deficient alpha-L-iduronidase, accumulations of heparin sulfate and dermatan sulfate in heart, brain, liver, and other organs, progressive, hepatosplenomagaly, dwarfism, gargoyle-like facies, stubby fingers, corneal clouding, mental retardation, death by 10 years of age
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Hurthle cell
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epithelial cells with eosinophilc granular cytoplasm; seen in hashimoto
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Hutchinson freckle
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aka lentigo maligna, precursor to lentigo maligna melanoma
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Hyaline thrombi
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TTP
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Hydrosalpinx
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Chronic pelvic inflammatory disease
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Hyperphagia + hypersexuality + hyperorality + hyperdocility
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Klüver-Bucy syndrome (amygdala)
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Hyperpigmentation of skin
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1° adrenal insufficiency (Addison’s disease)
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Hypersegmented neutrophils (PMNs)
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Macrocytic (megaloblastic) anemia
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Hypochromic microcytosis
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Iron deficiency anemia, lead poisoning
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IgM against IgG
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Rheumatoid arthritis (rheumatoid factor)
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Increased uric acid levels
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Gout, Lesch-Nyhan syndrome, myeloproliferative disorders, loop and thiazide diuretics
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Increased α-fetoprotein in amniotic fluid/maternal serum
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Anencephaly, spina bifida (neural tube defects)
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Index finger overlapping 3rd and 4th
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Edward’s (Trisomy 18)
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Intussusception
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Adenovirus (causes hyperplasia of Peyer’s patches)
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Jacksonian Seizures
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epileptic events originating in the 1° motor cortex (area 4)
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Janeway lesions
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Endocarditis
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Jarisch-Herxheimer Reaction
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Syphilis over-aggressive treatment of an asymptomatic pt. that causes symptoms 2° to rapid lysis
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Job’s Syndrome
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immune deficiency
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Joint Mice
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osteoarthritis (fractured osteophytes)
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Kaposi Sarcoma
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malignant vascular tumor (HHV8 in homosexual men)
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Kartagener syndrome
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immotile cilia 2° to "defective dynein", sinusitis, bronchiectasis, situs inversus, sometimes hearing loss and male sterility
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Kaussmaul Breathing
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acidosis
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Kawasaki Dz
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aka mucocutaneous lymph node syndrome, acute self-limited, infants and young kids, acute necrotizing vasculitis of small and medium vessels, fever hemorrhagic edema of conjunctivae, lips and oral mucosa, and cervical LAD, can cause coronary artery vasculitis with aneurysm formation
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Kayser Fleischer ring
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ring of copper deposited around iris; seen in Wilson Dx
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Keratin pearls
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SCC
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Keratoconjunctivitis
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adenovirus
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Kernig’s sign
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meningitis
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Kimmelstiel Wilson nodules
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mesangial matrix material acculmulations; seen in nodular glomerulosclerosis & diabetic nephropathy
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Klinefelter syndrome
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at least 2 X and one Y, hypogonadism, tall, gynecomastia, low testosterone, high pituitary gonadotropins, infertility,
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Kluver-Bucy
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bilateral lesions of amygdale (hypersexuality; oral behavior)
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Koilocyte
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dysplastic cell seen in HPV
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Koplik Spots
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measles
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Krabbe Disease
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Beta-galactosidase deficiency
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Krukenberg Tumor
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metastatic stomach CA to ovary; adenocarcinoma with signet-ring cells (typically originating from the stomach) metastases to the ovaries
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Kussmaul hyperpnea
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Diabetic ketoacidosis
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Lacunar cells
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Variant of Reed-Sternberg cell seen in nodular sclerosing Hodgkin’s Disease
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Lacunar infarct
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Chronic HTN
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Laennec’s Cirrhosis
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alcoholic cirrhosis
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Lamellar bodies
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Contain surfactant in Type II pneumocytes
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Langhans giant cell
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Tuberculosis, other including coccidioides; nuclei arranged in horseshoe-shaped pattern about periphery of cell, characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)
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Lemon sign
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Ultrasonographic finding in Neural Tube Defects
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Lemon yellow skin color
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Pernicious anemia
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Lens dislocation + aortic dissection + joint hyperflexibility
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Marfan’s syndrome (fibrillin deficit)
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Lesch Nyhan syndrome
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deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT), low purine metabolism, high uric acid, thus gout, mental retardation, choreoathetosis, spasticity, self mutilation, aggressiveness
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Letterer Siwe dx
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aka acute disseminated langerhans cell histiocytosis, aggressive, usually fatal, kids hepatosplenomegaly, LAD, pancytopenia, pulmonary involvement, recurrent infections
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Leukocoria
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Retinoblastoma
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Leukocyte alk. Phos. Positive
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leukemoid rxn.
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Lewy Bodies
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Parkinson’s (eosinophilic inclusions in damaged substantia nigra cells)
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Li Fraumeni syndrome
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lots of tumors, breast CA, soft tissue sarc, brain tumors, leukemias, has loss of p53 tumor suppressor gene
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Libman-Sacks
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endocarditis with small vegetations on valve leaflets, associated with SLE
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Lines of Zahn
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arterial thrombus
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Lisch nodules
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pigmented iris hamartoma; Neurofibromatosis (von Recklinghausen’s disease)
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Loss of grey-white junction
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Tuberous sclerosis
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Lou Gehrig’s
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Amyotrophic Lateral Sclerosis degeneration of upper & lower motor neurons
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Low serum ceruloplasmin
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Wilson’s disease
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Low set ears
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Downs, DiGeorge, Trisomy 18 (Edwards)
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Lucid interval
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Epidural hematoma
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Lumpy-bumpy” appearance of glomeruli on immunofluorescence
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Poststreptococcal glomerulonephritis
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Lynch syndrome
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hereditary nonpolyposis colon cancer, DNA repair genes messed up
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Lytic bone lesions on x-ray
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Multiple myeloma
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Machine-like murmur
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Patent ductus arteriosus
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Macronodular cirrhosis
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Wilson’s, viral hepatitis, alpha-1-antitrypsin
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Malignant pustule
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Anthrax (black skin lesion)
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Mallory Bodies
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Alcoholic liver disease
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Mallory-Weis Syndrome
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bleeding from esophagogastric lacerations 2* to wretching (alcoholics)
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Maple syrup/burnt sugar urine
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Alpha-ketoacid dehydrogenase deficiency; valine, leucine and isoleucine build up (branched)
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Marfan syndrome
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deficient fibrillin (constituent of microfibrils), arachnodactyly, ectopia lentis, aortic aneurysm, mitral valve prolapsed, cystic medial necrosis, subluxed lens
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McArdle’s Disease
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glycogen storage disease (muscle phosphorylase deficiency), skeletal muscle cramps with exertion
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McBurney’s Sign
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appendicitis (McBurney’s Point is 2/3 of the way from the umbilicus to anterior superior iliac spine)
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McCune Albright syndrome
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polyostotic fibrous dysplasia, precocious puberty, café au lait spots, short stature, young girls
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Meckel’s Diverticulum
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rule of 2’s
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Meconium ileus
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Cystic Fibrosis
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Mediterranean anemia or Cooley Anemia
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B Thalassemia major
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Mees lines
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Arsenic (parallel lines on fingernails)
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Meig’s Syndrome
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Triad
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Melanosis coli
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Laxative abuse
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Menetrier’s Disease
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giant hypertrophic gastritis (enlarged rugae; plasma protein loss)
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Meningioma
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Arachnoid cap cells, whorls of cells
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Mental probs. with heart defect
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Mitral prolapse
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Mesothelioma
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Asbestos exposure
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Michealis-Gutmann Bodies
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Malakoplakia, an abnormal tissue response to kidney infection
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Microglial nodules
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HIV
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Micrognathia
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DiGeorge
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Micronodular cirrhosis
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Wilsons, alcoholic, hemochromatosis, 1° biliary cirrhosis
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Microsatellite instability
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HNPCC (right-sided colon cancer), but also possible in other cancers
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Mid-systolic click
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Mitral valve prolapse
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MLF syndrome (INO)
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Multiple sclerosis
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Monckeberg’s Arteriosclerosis
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calcification of the media (usually radial & ulnar aa.), pipestem arteries
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Monoclonal antibody spike
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Multiple myeloma (called the M protein; usually IgG or IgA), MGUS (monoclonal gammopathy of undetermined significance), Waldenström’s (M protein
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Mousy / musty odor
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PKU
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Mucosal bleeding
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Platelet problem (qualitative or quantitative)
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Munchausen Syndrome
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factitious disorder (consciously creates symptoms, but doesn’t know why)
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Munro abscesses
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minute neutrophilic abscesses found within parakeratotic stratum corneum in psoriasis
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Myxedema
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hypothyroidism
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N
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myc :
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Names of Vitamins
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B1 thiamine, B2 riboflavin, B3 niacin, B6 pyridoxine, B12 cobalamin, C ascorbic acid, D calciferol, E a-tocopherol
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Necrolytic migratory erythema dermatitis
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?-cell islet tumor
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Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis
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Wegener’s and Goodpasture’s (hemoptysis and glomerular disease)
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Needle-shaped, negatively birefringent crystals
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Gout
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Negri bodies
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eosinophilic intracytoplasmic inclusions in hippocampus and purkinje cells seen in rabies infection (w/ hydrophobia)
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Nelson’s Syndrome
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1* Adrenal Cushings * surgical removal of adrenals * loss of negative feedback to pituitary * Pituitary Adenoma
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Nephritis + cataracts + hearing loss
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Alport’s syndrome
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Neuritic Plaques
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Alzheimer’s
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Neurofibrillary tangles
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Alzheimer’s disease
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NF1
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tumor suppressor mutated in Von Recklinhousen
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Niemann-Pick
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Lysosomal Storage Disease sphingomyelinase deficiency,“foamy histiocytes” in liver, spleen, lymph nodes, skin, hepatosplenomegaly, anemia fever, occasional neuro degeneration, half have cherry red spot macula
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Night pain relieved by aspirin
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Osteoid osteoma
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No lactation postpartum
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Sheehan’s syndrome (pituitary infarction)
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Non-embolizing endocarditis
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Rheumatic, Libman-Sacks (with SLE)
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Non-pitting Edema
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Myxedema, Anthrax Toxin
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Notching of Ribs
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Coarctation of Aorta
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Nutmeg Liver
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CHF, right heart
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Occupational exposure to asbestos
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Malignant mesothelioma
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Ochronosis (dark pigment of fibrous tissue)
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Alkaptonuria –homogentisic acid oxidase deficiency
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Oligoclonal band
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Multiple sclerosis
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Onion skin kidney arterioles
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Malignant nephrosclerosis (malignant HTN)
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Orphan Annie” nuclei
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Papillary carcinoma of the thyroid
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Osler Weber Rendu syndrome
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aka hereditary hemorrhagic telangectasia, telangectasias in skin and mucous membranes, epistaxis, GI bleeds
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Osler’s nodes
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Endocarditis
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Osteogenesis imperfecta
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Type I collagen defect
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Osteoid production
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osteosarcoma
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Owl’s eye
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CMV
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p53
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gene product facilitates apoptosis, decreases bcl::2 and increases Bax
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p53
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tumor suppressor gene, pretty much the coolest one
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Paget dx of bone
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aka osteitis deformans, increased osteoclastic and osteoblastic activity; abnormal bone architecture (thickened, numerous fractures * pain) , woven and lamellar bone mosaic
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Paget dx of breast
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eczematoid lesion of nipple areola, large cells with clear "halo like" area, invade epidermis, underlying ductal CA
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Paget dx of vulva
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similar to paget breast, sometimes related to underlying adenoCA of sweat glands
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Painless Jaundice
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pancreatic CA (head)
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Palatal Petechaie
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Strep pharyngitis
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Palpable purpura
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Hypersensitivity vasculitis (Henoch-Schonlein, serum sickness)
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Pancarditis
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Rheumatic fever
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Pancoast’s tumor
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Bronchogenic apical tumor (superior sulcus) associated with Horner’s syndrome
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Pannus
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rheumatoid arthritis
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Parkinson’s
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nigrostriatal dopamine depletion in nigrostriatal tracts; Cogwheel rigidity
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PAS positive macrophages
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Whipple’s disease
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Patau syndrome
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aka trisomy 13, mental retardation, microcephaly, micropthalmia, brain abnormalities, cleft lip/palate, polydactyly, rockerbottom feet, congenital heart dx
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Patent ductus arteriosus
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Maternal rubella and prematurity
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Pautrier’s Microabscesses
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mycosis fungoides (cutaneous T-cell lymphoma)
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Periductal edema
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Gynecomastia
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Periosteal elevation on x-ray
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Pyogenic osteomyelitis
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Periventricular Calcifications
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Congenital CMV (brain ventricles, that is)
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Peutz-Jegher’s Syndrome
|
benign polyposis; melanin pigmentation of lips, mouth, hand, genitalia plus hamartomatous polyps of small intestine; higher incidence of adeno CA of colon and other malignancies, stomach, breast, ovaries
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Peyronie’s Disease
|
subcutaneous fibrosis of dorsum of penis
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Phenylalanine hydroxylase deficiency
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PKU
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Philadelphia chromosome (bcr-abl )
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CML (may sometimes be associated with AML)
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Pick Bodies
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Pick’s Disease
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Pick’s Disease
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progressive dementia similar to Alzheimer’s, knife-edged gyri
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Piecemeal Necrosis
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Chronic active hepatitis (periportal hepatocytes)
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PIG A
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mutation
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Pink puffer”
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Emphysema (centroacinar [smoking], panacinar [α1-antitrypsin deficiency])
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Pink, foamy lung exudate
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Pneumocystis carinii pneumonia
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Plexiform lesions
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Pulmonary HTN (aneurismal expansion of vessel wall)
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Plummer’s Syndrome
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hyperthyroidism, nodular goiter, absence of eye signs (Plummer’s
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Plummer-Vinson
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esophageal webs & iron-deficiency anemia, ? SCCA of esophagus
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Podagra
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gout (MP joint of hallux)
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Podocyte fusion
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Minimal change disease
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Polyneuropathy preceded by GI or respiratory infection
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Guillain-Barré syndrome
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Polyneuropathy, cardiac pathology, and edema
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Dry beriberi (thiamine, vitamin B1 deficiency)
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Pompe’s Disease
|
glycogen storage disease (acid maltase deficiency) * cardiomegaly; deficient a1,4 glucosidase, accumulation of glycogen in liver, heart, skeletal muscle, cardiomegaly, muscle hypotonia, spelnomegaly, intractable hypoglycemia, death from cardiorespiratory failure before age 3
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Porcelain gallbladder
|
Chronic cholecystitis (scarring)
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Porcelain gallstones
|
Associated with gallbladder adenocarcinoma
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Port-wine stain
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Hemangioma
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Posterior/Anterior Drawer Sign
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tearing of the PCL/ACL
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Pott’s Disease
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tuberculous osteomyelitis of the vertebrae
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Potter sequence
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oligohydramnios causes fetus to be smashed
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Potter’s Complex
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renal agenesis * oligohydramnios * hypoplastic lungs, defects in extremities
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Prader willi syndrome
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paternal transmission del (15)(q11q13), hypogonad, hypotonia, mental retardation, behavior probs, uncrontrolled appetite
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Proliferating bile ducts
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Obstructive jaundice
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Psammoma Bodies
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Papillary adenocarcinoma of the thyroid, Serous papillary cystadenocarcinoma of the ovary, Meningioma, Mesothelioma
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Pseudohypertrophy
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Duchenne muscular dystrophy
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Pseudopalisade tumor cell arrangement
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Glioblastoma multiforme
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Pseudopolyps
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Ulcerative colitis
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Pseudorosettes
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Ewing’s sarcoma
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Ptosis, miosis, anhidrosis
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Horner’s syndrome (Pancoast’s tumor)
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Pulmonary atherosclerosis
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Cor pulmonale
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Punched-Out Bone Lesions
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multiple myeloma
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Punched-out esophageal lesions
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herpes
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Ras oncogenes
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oncogenes that code for p21 proteins which are membrane signalers
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Rash on palms and soles
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2° syphilis, Rocky Mountain spotted fever
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Raynaud disease
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different in that it is the primary disorder, recurrent vasospasm of small arteries and venules, pallor, cyanosis, fingers and toes, young healthy women
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Raynaud phenomenon
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vasosmasm of small vessels, most often in fingers, seen with autoimmune dx like SLE, scleroderma and others (R in CREST), recurrent vasospasm, always secondary to underlying disorder
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Rb gene
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retinoblastoma on chromosome
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RBC casts in urine
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Acute glomerulonephritis
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RBC poikilocytosis
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Beta-thalassemia
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Rectangular RBC’s
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Hemoglobin SC
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Recurrent pulmonary Pseudomonas and S. aureus infections
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Cystic fibrosis
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Red hyalin globules
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Alpha-1-antitrypsin deficiency (in liver)
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Red urine in the morning
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Paroxysmal nocturnal hemoglobinuria
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Reed-Sternberg cells
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Hodgkin’s lymphoma; binucleated or multinucleated giant
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Reid index (increased)
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Chronic bronchitis
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Reidel thyroiditis
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thyroid replacement by fibrous tissue, unkown origin, mimics CA
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Reinke crystal
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intracytoplasmic inclusions seen in leydig cell tumors
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Reiter’s Syndrome
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aka Reactive arthritis; urethritis, conjunctivitis, arthritis non-infectious (but often follows infections), HLA-B27, polyarticular
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Renal cell carcinoma + cavernous hemangiomas + adenomas
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von Hippel–Lindau disease
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Renal epithelial casts in urine
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Acute toxic/viral nephrosis
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ret
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protooncogene mutated in medulary thyroid CA (MENII)
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ret PTC
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associated with papillary thyroid CA
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Reye syndrome
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aspirin toxicity seen in kids after acute febrile viral Dz, microvesicular fatty change in liver and encephalopathy
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Rhomboid crystals, positively birefringent
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Pseudogout
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Rib notching
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Coarctation of aorta
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Riedel’s Thyroiditis
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idiopathic fibrous replacement of thyroid
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Rim pattern
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SLE, staining pattern with anti-double stranded DNA antibodies
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Rockerbottom feet
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Patau (Trisomy 13), Edward’s (Trisomy 18)
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Rose thorns
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Sporotrichosis
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Roth’s spots in retina
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Endocarditis
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Rotor Syndrome
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congenital hyperbilirubinemia (conjugated), similar to Dubin-Johnson, but no discoloration of the liver
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Rouleaux formation
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also seen in urine of MM, stacks of RBCs, will have high ESR
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Rugae loss
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Pernicious anemia (atrophic gastritis)
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Russell bodies
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Multiple myeloma
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S3
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L→R Shunt (VSD, PDA, ASD); Mitral Regurg; LV Failure (Rapid ventricular filling & Poor Left Ventricular Function)
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S4
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ventricular hypertrophy, causes of ventricular hypertrophy, restrictive ventricular Dz
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Scalloped colloid
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Grave’s disease
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Schiller-Duval bodies
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Yolk sac tumor
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Schwartzman Reaction
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Neisseria meningitidis impressive rash with bugs
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Senile plaques
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Alzheimer’s disease
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Sezary Syndrome
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leukemic form of cutaneous T-cell lymphoma (mycosis fungoides)
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Shagreen patches
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Tuberous sclerosis
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Shaver’s Disease
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aluminum inhalation ? lung fibrosis
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Sheehan’s Syndrome
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postpartum pituitary necrosis, low TSH /ACTH
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Shwartzman reaction
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Neisseria meningitidis
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Shy Drager syndrome
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parkinsonism with autonomic dysfunction and orthostatic hypotension
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Signet ring cell
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mucinous cell, characteristic of Gastric carcinoma met to ovary (krukenberg tumor)
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Simian crease
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Down syndrome
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Simmonds Dz
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aka pituitary cachexia, generalized panhypopituitarism
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Sipple’s Syndrome
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MEN type IIa (pheochromocytoma, thyroid medulla, parathyroid)
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Sjogren’s Syndrome
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triad
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Skip lesions
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Crohn’s
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Slapped cheeks
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Erythema infectiosum (fifth disease)
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Smith Antigen
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SLE (also anti-dsDNA)
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Smudge cells
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CLL (delicate leukemic B-cells easily destroyed on peripheral smear)
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Soap Bubble on X-Ray
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giant cell tumor of bone
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Soldiers plaque
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Clinically insignificant remnant of healed pericarditis
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Spider telangiectasia
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Hyperestrinism
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Spike & Dome Glomeruli on EM
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membranous glomerulonephritis
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Spitz Nevus
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juvenile melanoma (always benign)
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Splinter hemorrhages in fingernails
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infective Endocarditis
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Starry sky appearance
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on lymph node biopsy, seen with Burkitt lymphoma
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Stein Leventhal syndrome
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aka polycystic ovary syndrome, young women, amenorrhea, infertility, obesity, hirsutism
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Stevens-Johnson Syndrome
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erythema multiforme, fever, malaise, mucosal ulceration (often 2? to infection or sulfa drugs)
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Still’s Disease
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juvenile rheumatoid arthritis (absence of rheumatoid factor)
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Strawberry cervix
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Trichomonas vaginalis
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Strawberry gallbladder
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Cholesterolosis
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Strawberry tongue
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Scarlet fever, Kawasaki’s
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Streaky ovaries
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Turner’s syndrome
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String Sign on X-ray
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Crohn’s bowel wall thickening
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Struma Ovarii
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Thyroid teratoma of ovary
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Sturge Weber syndrome
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port wine stain on face, ipsilateral glaucoma, vascular lesions of ocular choroidal tissue, extensive hemangiomatous involvement of meninges
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Subepithelial humps on EM
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Poststreptococcal glomerulonephritis
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Suboccipital lymphadenopathy
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Rubella
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Sugar icing on spleen
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Portal HTN
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Sulfer granules
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Collection of Actinomyces israelii or nocardia organisms in chronic abscessing bronchopneumonia
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Swiss cheese brain
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Clostridia (gas forming)
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Swollen gums, bruising, poor wound healing, anemia
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Scurvy (ascorbic acid, vitamin C deficiency)—vitamin C is necessary for hydroxylation of proline and lysine in collagen synthesis
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Syncitia
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RSV, measles
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Systolic ejection murmur (crescendo-decrescendo)
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Aortic valve stenosis
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t(14;18)
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Follicular lymphomas (bcl-2 activation)
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t(8;14)
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Burkitt’s lymphoma (c-myc activation)
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t(9;22)
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Philadelphia chromosome, CML (bcr-abl hybrid)
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Tabes dorsalis
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3° syphilis
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Takayasu’s arteritis
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aka pulseless Dz, inflammation and stenosis of medium and large sized arteries, aortic arch syndrome, loss of carotid, radial or ulnar pulses
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Tamm-Horsfall protein
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Hyaline casts (non-specific)
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Target Cells
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Thalassemia
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Tay Sachs Dz
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deficient hexosaminidase A, GM2 ganglioside accumulation, especially in neurons, CNS degeneration, mental/motor deterioration, blindness, cherry red spot on macula, death by 4 years of age
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Teardrop RBCs
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myelofibrosis
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Temporal lobe encephalitis
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Herpes
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Tendon xanthomas (classically Achilles)
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Familial hypercholesterolemia
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Tethered cord
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Arnold-Chiari malformation (tonsilar herniation)
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Tetrahydrobiopterin cofactor def.
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PKU
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Tetralogy of Fallot
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ÊVSD, Ëoverriding aorta, Ìpulmonary artery stenosis, Íright ventricular hypertrophy
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TGI > TSI
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Hashimoto’s
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Thumb sign on lateral x-ray
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Epiglottitis (Haemophilus influenzae)
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Thymidine dimers
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Xeroderma pigmentosum
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Thymus, parathyroid agenesis
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Digeorge (3rd and 4th pharyngeal pouch)
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Thyroidization of kidney
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Chronic bacterial pyelonephritis
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TIBC increase
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Anemia of chronic disease
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Tingible Bodies
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Macrophage in lymph node germinal centers
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Tophi
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gout
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Tourette’s Syndrome
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involuntary actions, both motor and vocal
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Tram-track” glomeruli on LM
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Membranoproliferative glomerulonephritis
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Tree bark aorta
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Syphilis
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Trousseau’s Sign
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(2 different signs) visceral CA, classically pancreatic adenocarcinoma (migratory thrombophlebitis), hypocalcemia (carpal spasm w/ BP cuff)
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TSI > TGI
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Grave’s
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Turcot’s Syndrome
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adenomatous polyps of colon plus CNS tumors
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Turner syndrome
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45 XO, female hypogonadism, hypothyroid, short, webbed neck, 1* amenorrhea
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Typhoid Fever
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Bradycardia and in white people rose spots on abdomen
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Tyrosinase deficiency
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Albinism
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Uric Acid
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Gout, Lesch Nyhan, Myeloproliferative Disorders, Diuretics (Loop & Thiazides)
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Vincent’s Infection
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“trench mouth” - acute necrotizing ulcerative gingivitis
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Virchow’s Node
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supraclavicular node enlargement by metastatic carcinoma of the stomach
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Virchow’s triad
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Pulmonary embolism (triad
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VMA and metenephrins in urine
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Pheochromocytoma
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Von economo encephalitis
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infectious disorder, caused postencephalitic parkinsonism
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von Gierke’s Disease
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glycogen storage disease (G6Pase deficiency); accumulation of glycogen in liver and kidney, hepatomegaly, hypoglycemia
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von Hippel-Lindau
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hemangioma (or hemangioblastoma), adenomas of the viscera, especially renal cell carcinoma
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von Recklinghausen’s
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neurofibromatosis (NF-1) & café au lait spots & Lisch nodule (iris hamartomas) (often has: scoliosis, learning difficulties, eye problems and epilepsy)
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von Recklinghausen’s Disease of Bone
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osteitis fibrosa cystica (“brown tumor”) 2* to hyperparathyroidism
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von Willebrand’s Disease
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defect in platelet adhesion 2* to deficiency in vWF; increased bleeding time and PTT
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Waldenstrom’s macroglobinemia
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proliferation of IgM-producing lymphoid cells
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Wallenberg’s Syndrome
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Posterior Inferior Cerebellar Artery (PICA) thrombosis “Medullary Syndrome”, Ipsilateral
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Warthin-Finkeldey Giant Cells
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Measles
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Waterhammer pulse
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Aortic regurgitation
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Waterhouse-Friderichsen
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catastrophic adrenal insufficiency 2* to hemorrhagic necrosis (eg, DIC), often 2* to meningiococcemia
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Waxy casts
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Chronic end-stage renal disease
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WBC casts in urine
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Acute pyelonephritis
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WBCs in urine
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Acute cystitis
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Weber’s Syndrome
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Paramedian Infarct of Midbrain, Ipsilateral
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Wegener granulomatosis
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unknown etiology, necrotizing granulomatous vasculitis of small to medium sized vessels of the respiratory tract, kidneys, and other organs, circulating C-ANCAs
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Weil’s Disease
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leptospirosis
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Werdnig Hoffman syndrome
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aka infantile progressive spinal muscular atrophy, autosomal recessive, LMN disease, infants
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Wermer’s Syndrome
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MEN type I (thyroid, parathyroid, adrenal cortex, pancreatic islets, pituitary)
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Wernicke Korsakoff syndrome
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thiamine deficiency, cerebral dysfunction, aka alcoholic encephalopathy, hemorrhagic lesions in the mamillary bodies, confusion, ataxia, ophthalmoplegia, and memory loss plus confabulation
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Wernicke’s Aphasia
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Sensory Aphasia impaired comprehension
|
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Wernicke-Korsakoff Syndrome
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thiamine deficiency in alcoholics; bilateral mamillary bodies (confusion, ataxia, ophthalmoplegia)
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Whipple triad
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seen in insulinoma, episodic hyperinsulinemia and hypoglycemia, CNS dysfunction, reversal of CNS probs with administration of glucose
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Whipple’s Disease
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malabsorption syndrome (with bacteria-laden macrophages) & polyarthritis; caused by Tropheryma whippelii; small intestine commonly affected, arthralgias, cardiac, and neuro symptoms
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White matter petechiae
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Fat emboli
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Wilms tumor
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clear cell renal tumor seen in kids
|
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Wilson’s Disease
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hepatolenticular degeneration (copper accumulation due to transport problem & decrease in ceruloplasmin); autosomal recessive, hepatitis, kayser fleischer rings in eyes
|
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Winged scapula
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Long thoracic nerve (C5,6,7) damage, common with radical mastectomy
|
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Wire Loop Glomeruli
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lupus nephropathy, type IV
|
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Wiskott Aldrich syndrome
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x linked, aka immunodeficiency (combined B- &T-cell deficiency) with thrombocytopenia and eczema; total immunoglobulins often normal, recurrent infections
|
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Wolff-Chaikoff Effect
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high iodine level (*)’s thyroid hormone synthesis
|
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Worst headache of my life”
|
subarachnoid hemorrhage/ Berry aneurysm—associated with adult polycystic kidney disease
|
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Wrinkled glomerular basement membrane
|
ischemia
|
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WT1 and WT2
|
tumor suppressor mutated in wilms tumor
|
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Xanthochromia (CSF)
|
Subarachnoid hemorrhage
|
|
Xerostomia + arthritis + keratoconjunctivitis sicca
|
Sjögren’s syndrome
|
|
Zenker’s Diverticulum
|
Upper GI diverticulum; esophageal; just above upper esoph sphincter; cricopharyngeal muscles above UES
|
|
Zollinger-Ellison
|
gastrin-secreting tumor of pancreas (or intestine) * * acid * intractable ulcers
|