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23 Cards in this Set

  • Front
  • Back
Which drug classes suppress pain transmission
local anesthetics
Which drug classes suppress pain modulation
spinal opioids
alpha agonists
ketamine
anticholinesterase
Which drug classes suppress pain transduction
NSAIDS
Antihistamines
local anesthetics
opioids
Which drug classes suppress pain perception
opioids
alpha agonists
general anesthetics
Exaggerated response to noxious stimuli
Mechanical hyperalgesia
Activation and sensitization of peripheral nociceptors through the release of chemical mediators like substance P, glutamate, bradykinin
primary sensitization
What happens during central sensitization
increase in receptive field size
Abeta fibers activate dorsal horn neurons
Mechanical hyperalgesia and allodynia are examples of
secondary hyperalgesia
COX that is consititutively active
COX 1
COX that is inducible in response to injury
COX 2
How do NSAIDS work
they block the transition of arachidonic acid to PG
How does ketamine work
NMDAR antagonist
Reduces Ca influx
Responsible for ketamines psychomimetic affects
k agonist
How do opioids work presynaptically
decrease the release of sub P and glutamate
How do opioids work postsynaptically
hyperpolarizes neurons in the substantia gelatinosa of the dorsal horn
How do alpha 2 agonists work presynaptically
they decrease NE release in the brain
How does pregabalin and gabapentin work
decreases voltage gated sodium and calcium channels
Transmit immediate pain
A delta
Transmit aching pain
C fibers
Transmit vibratory, light touch, pressure
A betta fibers
Where do A delta and C fibers synapse in the dorsal horn
lamina 1 & 2
Lamina 5
Where do A beta fibers synaps on the dorsal horn
Lamina 3-5
What type of patient should not recieve NSAIDS during surgery
cardiac history
increased risk for MI