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23 Cards in this Set
- Front
- Back
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Which drug classes suppress pain transmission
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local anesthetics
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Which drug classes suppress pain modulation
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spinal opioids
alpha agonists ketamine anticholinesterase |
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Which drug classes suppress pain transduction
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NSAIDS
Antihistamines local anesthetics opioids |
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Which drug classes suppress pain perception
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opioids
alpha agonists general anesthetics |
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Exaggerated response to noxious stimuli
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Mechanical hyperalgesia
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Activation and sensitization of peripheral nociceptors through the release of chemical mediators like substance P, glutamate, bradykinin
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primary sensitization
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What happens during central sensitization
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increase in receptive field size
Abeta fibers activate dorsal horn neurons |
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Mechanical hyperalgesia and allodynia are examples of
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secondary hyperalgesia
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COX that is consititutively active
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COX 1
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COX that is inducible in response to injury
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COX 2
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How do NSAIDS work
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they block the transition of arachidonic acid to PG
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How does ketamine work
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NMDAR antagonist
Reduces Ca influx |
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Responsible for ketamines psychomimetic affects
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k agonist
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How do opioids work presynaptically
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decrease the release of sub P and glutamate
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How do opioids work postsynaptically
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hyperpolarizes neurons in the substantia gelatinosa of the dorsal horn
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How do alpha 2 agonists work presynaptically
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they decrease NE release in the brain
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How does pregabalin and gabapentin work
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decreases voltage gated sodium and calcium channels
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Transmit immediate pain
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A delta
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Transmit aching pain
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C fibers
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Transmit vibratory, light touch, pressure
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A betta fibers
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Where do A delta and C fibers synapse in the dorsal horn
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lamina 1 & 2
Lamina 5 |
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Where do A beta fibers synaps on the dorsal horn
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Lamina 3-5
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What type of patient should not recieve NSAIDS during surgery
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cardiac history
increased risk for MI |
