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41 Cards in this Set
- Front
- Back
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microglia biomarker____
active microglia marker____ |
Ox-42
CD11b |
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ox-42 is what?
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marker of microglia
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CD11b is what?
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marker of active microglia
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GFAP is marker of what?
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astrocyte
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astorcytes have deposits of ___with intertwined____s
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glycogen
GFAPs |
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2most important animal models are....
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bennett and chung
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Which animal model has Chronic contraction ligation, and sciatic n ligation?
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bennett
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which animal model has ligation of spinal n?
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chung
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taxol is an animal model in what way?
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anti-cancer drug that induces axon degen/neuro pain
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what anti-cancer drug is used for animal studies because it induces axon degen/neuro pain
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taxol
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2 types of astrocytes
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proto - grey
fibrous - white |
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6 functions of astrocytes
compar... phys.... reg.... signal.... respond... contribte |
compartmentalize the brain
phys support for neurons regulate EC space content Signal to neurons respond to CNS injury contribute to BBB formation |
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what glia are 20% of all glia
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micro
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what glia? forms the BBB
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ependymal
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ependymal cell function
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form BBB
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adjacent astrocyte communicate via
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GAP
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distant astrocytes communicate via
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ATP
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astrocytes...
increase in ____causes them to uptake_____. Then, if _____increases, they willl ______. |
ca
glutamate na release glutamate |
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D-serine 2 things
coactivate.... reduce transmission via... |
NMDA
TBP's |
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Difference between astro and micro glia based on Glu receptors?
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astro - iono, metabo, glutamate transporters
Micro - iono, glutamate transporter |
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main transmission mediator of neuro-glia?
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glutamate
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when a neuron is excited, how does it generate an AP in a glial cell
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IT NEVER DOES
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Glial receptors for ATP?
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P2X/P2Y
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what cells have p2x/p2y's? what are they?
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astro and micro
atp receptors |
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fractalkine is released by _____to activate ____'s, causing increase of _____'s ______.
Binds to _____ on the cell it acts on |
neuron
glials glial's Ca2+ Cx3Cr1 |
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what is Cx3Cr1?
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fractalkine receptors on glial's to increase Ca2+
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2 protein kinases used in glial signalling?
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p38 and ERK
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p38 erk are what?
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protein kinases of glial signalling
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are all glial in pain production? if not, name 1 that isnt
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no
oligodendrocytes - INHIBIT CNS |
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astrocyte/microglia
which is involved in the ONSET of pain? |
micro
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astro/micro
which is involved in scar/cytokine/maintenance? |
astro
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the 2 main cytokines released by glia to further excite a neuron?
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TNF-a and IL1b
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Anti-pain cytokine by glial cells?
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IL10
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which is anti-pain?
IL10 IL1b IL6 TNFa |
IL0
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chemokines are rlesaed by (neuro/glia) and mediate ____.
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neurons
chenmotaxis |
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the chemokines used by neurons on glia to mediate chemotaxis are based on the presence of a ____residue
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cystein
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3 astrocyte drugs
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propentofylline - nonselective inhibitor
osteroprotegerin methyprednisolone |
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microglia drugs (3)
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minocycline
suramin propentofylline |
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Drugs working on astro and glia (2)
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fluorocitrate
propentofylline |
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Fluorocitrate - what doe sit do? how does it work?
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inhibits astro @ low dose
inhibits micro @ high dose too |
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the glial drugs...what do they do?
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inhibit glial cytokine production
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