Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
63 Cards in this Set
- Front
- Back
|
Dolobid?
|
Diflusinal. COX non-specific NSAID.
|
|
|
Trilisate?
|
Choline Magnesium Trisalicylate. COX non-specific NSAID.
|
|
|
Colchicine?
|
Treatment of gouty arthritis.
|
|
|
Colchicine MOA?
|
Decreases leukocyte motility, which decreases phagocytosis in joints, thereby reducing urate crystallization.
|
|
|
Ibuprofen?
|
Porpionic acid NSAID.
|
|
|
Nalfon?
|
Fenoprofen. Propionic acid NSAID.
|
|
|
Ansaid?
|
Flurbiprofen. Propionic acid NSAID.
|
|
|
Orudis?
|
Ketoprofen. Propionic acid NSAID.
|
|
|
Daypro?
|
Oxaprozin. Propionic acid NSAID.
|
|
|
Propionic acid NSAIDs?
|
Motrin, Advil, others
Nalfon® Ansaid® Orudis® Nalfon® Daypro® |
|
|
Acetic acid NSAIDs.
|
Indocin®
Naprosyn, Aleve® Clinoril® Tolectin® Relafen® Voltaren® Arthrotec® Toradol® |
|
|
Clinoril?
|
Sulindac
|
|
|
All non selective COX inhibitors have a center of acidity to mimic______?
|
The carboxy of Arachadonic Acid.
|
|
|
What occurs with the substitution of a methyl group on the carbon separating the acid center of and NSAID?
|
Increased activity via change to propionic acid.
|
|
|
Indomethacin and Sulindac are based on the ___________backbone?
|
Seratonin
|
|
|
Tolmetin, Diclofenac, Ketorolac and Etodolac are Heteroaryl derivatives of_________.
|
Indomethacin
|
|
|
Non-acidic NSAID prodrug?
|
Nabumetone (Relafen)
|
|
|
Most acidic NSAID?
|
Meloxicam
|
|
|
NSAID most preferential for COX-2?
|
Meloxicam
|
|
|
Mobic?
|
Meloxicam
|
|
|
Reason oxicam NSAIDs have such strong activity in the joints?
|
Site of inflammation pH~3, so oxicams are ionized at physiological pH but unionized at site of inflammation, leaving them trapped there.
|
|
|
Voltaren?
|
Diclofenac. Acetic acid NSAID.
|
|
|
Toradol?
|
Ketorolac. Acetic acid NSAID.
|
|
|
Lodine?
|
Etodolac. Acetic acid NSAID.
|
|
|
Feldene?
|
Piroxicam. Oxicam NSAID.
|
|
|
Drug that inhibits COX-3 in the brain>
|
Acetaminophen
|
|
|
The steroid 4-5 C=C bond and 3-keto on ring A are essential for?
|
Both GR and MR activity
|
|
|
The steroid 11b-OH or 11-keto group on ring C is required for________?
|
GR but not MR activity
|
|
|
Introduction of C=C double bond between C1-C2 on steroids has what effect?
|
Selective increases GR activity
|
|
|
What is the significance of methylation at position 6 on the steroid SAR?
|
6a-methylprednisolone potentiates glucocorticoid activity with negligible salt retention. The 6a-methyl group decreases affinity for MR.
|
|
|
What is the significance of the 16a-methyl group on dexamethasone?
|
16a-methyl group increases resistance to metabolism, increasing duration of action nearly two-fold.
|
|
|
What is the significance of the 17α-hydroxyl group on ring D of the steroid SAR?
|
Optimal Potency
|
|
|
The significance of Fluorination at 9α on ring B of the steroid SAR is?
|
Enhanced activity
|
|
|
C16 subsitutions on ring D of the steroid SAR confer what activity?
|
Elimination of mineralocorticoid activity
|
|
|
Buprenex?
|
Buprenorphine. Kappa / mu Mixed Agonists for moderate to severe pain/
|
|
|
Stadol?
|
Butorphanol. Kappa / mu Mixed Agonists for moderate to severe pain.
|
|
|
Nubain?
|
Nalbuphine. Kappa / mu Mixed Agonists for moderate to severe pain.
|
|
|
Talwin?
|
Pentazocine. Kappa / mu Mixed Agonists for moderate to severe pain.
|
|
|
Dalgan?
|
Dezocine. Kappa / mu Mixed Agonists for moderate to severe pain.
|
|
|
One of, if not the, most addictive opiod substance known?
|
Diacetylmorphine
|
|
|
Zanaflex?
|
Tizanidine. Alpha-2 agonist, muscle relaxant.
|
|
|
Plaquenil?
|
Hydroxychloroquine. Antimalarial that can be used for SLE and rheumatoid arthritis.
|
|
|
3 signals required for T-cell activation?
|
Antigen binding
Co-stimulator Molecules Signal transduction |
|
|
3rd signal in T-cell activation?
|
Secretion of IL-2.
|
|
|
MOA of Cyclosporine?
|
Cyclosporine specifically interferes with IL-2 formation
|
|
|
Hypersensitivity types: 1-4 ?
|
Allergy
Cytotoxic Immune Complex Cell mediated (delayed) |
|
|
Type 1 immune reaction?
|
Allergy (immediate). Examples include: Atopy, Anaphylaxis and Asthma.
|
|
|
Mediator of type 1 immune reactions?
|
IgE
|
|
|
Type 2 immune reaction?
|
Cytotoxic or antibody-dependent reaction. Examples:
Autoimmune hemolytic anemia Erythroblastosis fetalis Goodpasture's syndrome |
|
|
Mediator of type 2 immune reactions?
|
IgM or IgG
(Complement) |
|
|
Type 3 immune reaction?
|
Immune complex disease. Examples include:
Serum sickness Arthus reaction SLE |
|
|
Mediator of type 3 immune reaction?
|
IgG
(Complement) |
|
|
Type 4 immune reaction?
|
Delayed-type hypersensitivity (DTH), antibody-independent. Examples include:
Contact dermatitis Tuberculin skin test Chronic transplant rejection |
|
|
Mediator of type 4 immune reactions?
|
T-cells. Antibodies not involved here
|
|
|
Humoral immune reactions?
|
Types 2 and 3 that involve compliment.
|
|
|
Most abundant immunoglobulin?
|
IgG
|
|
|
Immunoglobulin on B-cells?
|
IgM
|
|
|
Largest immunoglobulin?
|
IgM
|
|
|
Primary antibody against A and B antigens on red blood cells
|
IgM
|
|
|
Immunoglobulin most concentrated in mucosal linings?
|
IgA
|
|
|
Type III reactions are most likely to occur in areas of ______________?
|
Slow blood flow, like the joints and kidneys.
|
|
|
Immune reaction type that causes rheumatoid arthritis?
|
Type 3. (Type 4 if TNF release is stimulated by T cells)
|
|
|
Immune reaction type that causes rheumatoid diabetes?
|
Type 4
|
