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21 Cards in this Set
- Front
- Back
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Acetaminophen (APAP, NAPAP)
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non-opioid analgesic
-centrally acting (in CNS) COX inhibitor -decreases pain, not really inflammation -no action peripherally, so lacks non-specific (peripheral) COX inhibitor side effects -has hepatotoxicity potential, esp with ethanol, and has some drug interactions (dose related) |
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Aspirin (ASA)
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-analgesic and anti-inflammatory activity
-has non-specific (peripheral) COX inhibitor side effects -GI mucosal irritation/ulceration -qualitative platelet defect -irreversible effect on platelets...inhibits start of clotting -renal impairment -best used with mild opioid |
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Choline salicylate
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non-acetyl salicylates
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Magnesium salicylate
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non-acetyl salicylate
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Choline
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non-acetyl salicylate
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magnesium trisalicylate
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non-acetyl salicylate
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salsalate
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non-acetyl salicylate
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Non-acetyl salicylate
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-analgesic and anti-inflammatory activity
-has some non-specific (peripheral) COX inhibitor side effects, but less so than other agents (controversy about their COX inhibition) -less GI mucosal irritation/ulceration -almost no platelet defect (only effects platelets as long as there's still drug) -best used with mild opioid |
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non-specific COX inhibitors
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-several chemical groups (little practical value)
-many available OTC -inhibit both COX 1 and COX 2 so potential for GI, platelet and renal side effects -some also have hepatotoxicity potential -some evidence suggests that ibuprofen and some others are relatively safer, esp for GI |
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Ibuprofen
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non-specific COX inhibitors
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Naproxen
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non-specific COX inhibitor
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Ketoprofen
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non-specific COX inhibitor
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Etodolac
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non-specific COX inhibitor
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Meclofenemate
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non-specific COX inhibitor
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Piroxican
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non-specific COX inhibitor
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Nabumetone
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non-specific COX inhibitor
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Oxaprozin
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non-specific COX inhibitor
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Sulindac
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non-specific COX inhibitor
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Tolmetin
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non-specific COX inhibitor
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Diflunisal
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non-specific COX inhibitor
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Celecoxib
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COX-2 specific inhibitor
-no more effective than COX nonspecific drugs -COX-2 agents cause LESS GI ulceration but they are NOT devoid of this potential -COX-2 agents have NO advantage for renal side effects according to most sources -COX-2 agents DO have less platelet effects but this might be a disadvantage to some (increased potential for thrombotic events) |
