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30 Cards in this Set
- Front
- Back
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What is NSAID
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Nonsteroidal antiinflammatory Drugs
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What does an NSAID do?
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Inhibits synthesis of prostaglandins and related compounds
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What is COX enzyme?
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cyclooxygense enzyme that is converted into prostaglandin
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Most widely used NSAIDS (COX inhibitors are:
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aspirin, ibuprofin, Toradol, naproxen sodium
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Which COX inhibitor provides relief but no anti-inflammatory effect?
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Tylenol - Acetaminophen
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Which are COX inhibitor useful effects?
suppression of inflammation pain relief reduction of fever reduction in platelet aggregation (aspirin) |
all of above
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Major adverse effects of NSAIDS are:
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gastic ulceration
bleeding acute renal failure |
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Aspirin belongs to what family?
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salicylates
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What is only irreversible COX inhibitor?
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Aspirin
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What is neccessary for platelet aggregation suppression?
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COX-1
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Low dose aspirin (75-325 mg/day) used for:
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reduce risk related to
strokes TIA acute MI previous MI angina angioplasty revascularization procedures |
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Aspirin contraindictated for who?
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Those w/ bleeding disorders
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If aspirin used as anti-inflammatory, what changes?
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Doses larger and potential for side effects increases
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Long term effects of high dose tx w/ aspirin?
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Life threating gastric ulceration, perforation, and bleeding
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When should aspirin be discontinued re surgery?
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One week prior to an invasive procedure where bleeding will occur
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If pt allergic to aspirin, should they take ibuprofin?
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No, risk of cross sensitivity
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Ibuprofin produces more or less gastric bleeding than asprin?
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Less, and causes less inhibition of platelets. Safer to use with other anticoagulants. (GI distress and gastric ulceration in LT use)
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Tylenol (acetaminophen) is most frequently digested medicine in U.S. (T/F)
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True
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Tylenol has inflammtory effects. (T/F)
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False
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Tylenol inhibits platelet formation or aggregation, causes gastric ulcers or renal failure. (T/F)
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False
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Tylenol is toxic to liver in high doses. (T/F)
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True
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Tylenol liver damage minimized with what? (antidote for Tylenol)
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Mucomyst (acetylcysteine) Antidote for Tylenol
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What is an opiad?
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Any drug that has action similar to morphine
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Opiod used for?
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Pain control & analgesia
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Effects of opiods?
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Decrease GI motility
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Examples Of Opiods:
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Codeine, Fentanyl, Demerol (meripidine), methadone, morphine, synthetic codeine (oxycodone)
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Opiod adverse effects:
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respiratory depression
orthostatic hypotension urinary retention cough suppression nausea and vomiting euphoria sedation miosis (pupil constriction) |
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Antidote for Opiod overdose?
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Narcan using IV route (IM or SC ok) dose repeated every 2-3 min until satisfactory response. Effect starts w/i 5 min
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