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39 Cards in this Set

  • Front
  • Back
What is pain from a stimulus that does not normally provoke pain?
allodynia
What is absence of pain in response to stimulation that would normally be painful?
analgesia
What is unpleasant abnormal sensation, spontaneous or evoked?
dysesthesia
What is an increased response to a stimulus that is normally painful?
hyperalgesia
What is pain in distribution of nerve or nerves?
Neuralgia
What is a receptor preferentially sensitive to noxious stimulus or that would become noxious if prolonged?
nociceptor
What is abnormal sensation, whether spontaneous or evoked?
paresthesia
What is somatic pain?
damaged body tissues, it is well-localized, but variable in description and experience
What is visceral pain?
pain arising from viscera mediated stretch receptors, poorly localized, deep, dull, cramping
What is neuropathic pain?
spontaneous, burning, constant, throbbing, jabbing, stabbing, mild, moderate, sever, not along neuroanatomical lines
What is sympathetically-mediated pain?
peripheral nerve lesion and associated ANS changes
What is non-sympathetic medicated pain?
damage to peripheral nerve without ANS changes
What central pain?
abnormal central nervous system activity
What concdictions are due to neuropathic pain?
vulvar pain, interstitial cystitis, atypical facial neuralgia, fibromyalgia
What do you use to manage neuropathic pain?
tricyclics antidepressant, antiepileptic, opiate, methadone, lidocaine, capsacin, opiates, clonidine
What may chronic pain lead to?
irreversible intractable condition
What are some signs and symptoms of chronic pain?
immobility, muscle wasting, inc susceptability to dx, distrubed sleep, poor appetitie and nutrition, dependence on med, moody, modifies sex drive, interferes with work
Which size DRG sensory neurons are for nociception, thermoreceptive, chemoreceptive?
small
What kind of nerve fibers do medium diameter neruons exhibit?
A-delta
What kind fibers do small diameter neurons exhibit?
unmyelinated C fibers
What A-delta fibers perceive?
fast pain, perception well-localized
What do unmyelinated C fibers perceive?
slow pain, perception poorly localized
What does Sub P cause to be released?
bradykinin, histamine, PGE, IL1, protons, K, ATP
What receptor does Capsaicin activate?
TRPB1, thermosensitive receptor
How dose capsaicin work?
It causes local destruction of nociceptive terminals
Which lamina do nociceptive info relay to?
1-5 a-delta, 1,2 for c
What are the two ascending pain pathways?
lateral anterolateral tract, medial anterolateral tract
What kind of pain does the lateral anterolateral tract conduct?
fast, sharp
Where does the lateral anterolateral tract project to?
lateral thalamic nuclei
What kind of pain does the medial anterolateral tract conduct?
slow, diffuse ache
Where does medial anterolateral tract project to?
medial thalamic nuclei to anterior cingulate gyrus
What are the other nociceptive areas?
spinoreticular, spinomesencephalic, DCT
What NT are regulators of bulbospinal excitation?
5-HT and NE
What is erythromelalgia?
red, painful extremities, inherited or non-inherited
What is CRPS Type I?
allodynia/hyperalgesia beyond area of injured nerve, edema, skin blood flow abnormality
Wat is CRPS type II?
allodynia/hyperalgesia limited to injured nerve, possible motor dysfunction
What causes sympathetically-maintained pain?
abnormal activation of sympathetic efferent activity, there is a greater release of NE
WhWHat causes profound loss of pain sensitivity, defect in thermoregulation, anhydrosis, mental retardation, microcephaly?
Type IV sensory autonomic neuropathies
what do people with HSAN IV lack?
lack of tyrosine kinase that binds to nerve growth factor, no nociecptive neurons develop