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39 Cards in this Set
- Front
- Back
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What is pain from a stimulus that does not normally provoke pain?
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allodynia
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What is absence of pain in response to stimulation that would normally be painful?
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analgesia
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What is unpleasant abnormal sensation, spontaneous or evoked?
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dysesthesia
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What is an increased response to a stimulus that is normally painful?
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hyperalgesia
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What is pain in distribution of nerve or nerves?
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Neuralgia
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What is a receptor preferentially sensitive to noxious stimulus or that would become noxious if prolonged?
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nociceptor
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What is abnormal sensation, whether spontaneous or evoked?
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paresthesia
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What is somatic pain?
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damaged body tissues, it is well-localized, but variable in description and experience
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What is visceral pain?
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pain arising from viscera mediated stretch receptors, poorly localized, deep, dull, cramping
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What is neuropathic pain?
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spontaneous, burning, constant, throbbing, jabbing, stabbing, mild, moderate, sever, not along neuroanatomical lines
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What is sympathetically-mediated pain?
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peripheral nerve lesion and associated ANS changes
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What is non-sympathetic medicated pain?
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damage to peripheral nerve without ANS changes
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What central pain?
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abnormal central nervous system activity
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What concdictions are due to neuropathic pain?
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vulvar pain, interstitial cystitis, atypical facial neuralgia, fibromyalgia
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What do you use to manage neuropathic pain?
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tricyclics antidepressant, antiepileptic, opiate, methadone, lidocaine, capsacin, opiates, clonidine
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What may chronic pain lead to?
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irreversible intractable condition
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What are some signs and symptoms of chronic pain?
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immobility, muscle wasting, inc susceptability to dx, distrubed sleep, poor appetitie and nutrition, dependence on med, moody, modifies sex drive, interferes with work
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Which size DRG sensory neurons are for nociception, thermoreceptive, chemoreceptive?
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small
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What kind of nerve fibers do medium diameter neruons exhibit?
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A-delta
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What kind fibers do small diameter neurons exhibit?
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unmyelinated C fibers
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What A-delta fibers perceive?
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fast pain, perception well-localized
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What do unmyelinated C fibers perceive?
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slow pain, perception poorly localized
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What does Sub P cause to be released?
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bradykinin, histamine, PGE, IL1, protons, K, ATP
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What receptor does Capsaicin activate?
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TRPB1, thermosensitive receptor
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How dose capsaicin work?
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It causes local destruction of nociceptive terminals
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Which lamina do nociceptive info relay to?
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1-5 a-delta, 1,2 for c
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What are the two ascending pain pathways?
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lateral anterolateral tract, medial anterolateral tract
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What kind of pain does the lateral anterolateral tract conduct?
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fast, sharp
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Where does the lateral anterolateral tract project to?
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lateral thalamic nuclei
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What kind of pain does the medial anterolateral tract conduct?
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slow, diffuse ache
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Where does medial anterolateral tract project to?
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medial thalamic nuclei to anterior cingulate gyrus
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What are the other nociceptive areas?
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spinoreticular, spinomesencephalic, DCT
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What NT are regulators of bulbospinal excitation?
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5-HT and NE
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What is erythromelalgia?
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red, painful extremities, inherited or non-inherited
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What is CRPS Type I?
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allodynia/hyperalgesia beyond area of injured nerve, edema, skin blood flow abnormality
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Wat is CRPS type II?
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allodynia/hyperalgesia limited to injured nerve, possible motor dysfunction
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What causes sympathetically-maintained pain?
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abnormal activation of sympathetic efferent activity, there is a greater release of NE
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WhWHat causes profound loss of pain sensitivity, defect in thermoregulation, anhydrosis, mental retardation, microcephaly?
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Type IV sensory autonomic neuropathies
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what do people with HSAN IV lack?
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lack of tyrosine kinase that binds to nerve growth factor, no nociecptive neurons develop
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