Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
Quinidine
|
Inducer
|
|
|
Barbituates
|
Inducer (also induce the rate limiting step of heme synthesis: act on D-ALA Synthase; therefore CI with porphyrias, especially Acute Intermittent Porphyrias)
**Induce metabolism of most lipid soluble drugs: OCPs, carbamazepine, phenytoin, warfarin, your mom** |
|
|
St. Johns Wort
|
Inducer
|
|
|
Phenytoin
|
Inducer
|
|
|
Rifampin
|
Inducer
|
|
|
Griseofulvin
|
Inducer
|
|
|
Carbamazepine
|
Inducer (including its own metabolism)
|
|
|
Chronic EtOH Use
|
Inducer
|
|
|
Sulfonamides
|
Inhibitor
|
|
|
Isoniazid
|
Inhibitor
|
|
|
Cimetidine
|
Inhibitor
|
|
|
Ketoconazole
|
Inhibitor (Remember that the MOA is inhibition of the fungal P450 enzyme - 14-alpha-demethylase, so it will also inhibit hepatic P450)
|
|
|
Erythromycin (Macrolides)
|
Inhibitor
|
|
|
Grapefruit Juice
|
Inhibitor
|
|
|
Acute EtOH use
|
Inhibitor
|
|
|
Valproic Acid
|
Inhibitor
|
|
|
Chloramphenicol
|
Inhibitor
|
