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33 Cards in this Set

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Bentyl
Dicyclomine

caps- 10mg
tabs- 20mg
syrup- 10mg/tsp
inj

Use: IBS (irritable colon, spastic colon, mucous colitis)

Counsel: Take 30-60 minutes before meals

MOA: Antispasmodic/ Anticholinergic; Blocks ACH at the cholinergic (muscarinic) receptor of the gut

Similar to Levsin
Donnatal
Belladonna & Phenobarbital

Tabs (IR)- 16.2 mg PB/ dose
Elixir- 16.2 mg PB/ TSP
Extentabs (ER)- 3X the IR= 48.6 mg

Use: IBS and related problems

Phenobarbital is a calming agent= drowsiness (NO Alcohol)

DI: Strong CYP-450 INDUCER
Librax
Clindinium/ chlordiazepoxide

Caps- 2.5mg/ 5mg

Anticholinergic & Benzodiazepine (NO ALCOHOL)

Caution: may be habit-forming; BPH (decreased urine flow)
Tagamet and Tagamet HB
Rx- Cimetidine tablets- 300, 400, 800mg
Rx- Cimetidine soln- 300mg/ tsp
OTC- Cimetidine tabs- 200mg

MOA: H2 Receptor Antagonist

Antacids decreases cimetidine's absorption (only H2 receptor antagonist that chelates)

DI: Theophylline, Plavix, Coumadin (Cyp blocker)

Dosed frequently

CAUTION: Breast swelling/ Gynecomastia
Zantac
Ranitidine tabs- 150, 300mg
Ranitidine Effervescent tabs- 25mg
Ranitidine liquid- 75mg/ tsp
Ranitidine OTC tabs- 75, 150mg

MOA: H2 Receptor Antagonist

Dose: BID or HS (6 PM), as well as prn

Effervescent tabs are for infant or child in > 5mL of water

Therapeutic Dose= high
Maintenance Dose= low
Pepcid, Pepcid ODT, Pepcid AC, and Pepcid Complete
Rx- famotidine tabs- 20, 40mg
Rx- famotidine ODT- 20, 40mg
Rx- famotidine susp- 40mg/ 5mL
OTC- famotidine tab- 10, 20mg
OTC- famotidine chewable tab plus CaCO3 and Mg(OH)2

MOA: H2 Receptor Antagonist

Can be taken with Antacids

Most commonly used H2RA, has few drug interactions
Axid and Axid AR
Rx- Nizatidine caps- 150, 300 mg
Rx- Nizatidine soln- 150mg/ 10mL
OTC- Nizatidine tabs- 75 mg

MOA: H2 Receptor Antagonist

Few drug interactions, Not advertised, not popular
Prilosec
Rx- omeprazole Caps ER- 10, 20, 40 mg
OTC- omeprazole tabs ER- 20 mg

MOA: Proton Pump Inhibitor-acid activated prodrug at pKa <4

DI: omeprazole inhibits conversion of Plavix (risk of clot) to active form and inhibits metabolism of warfarin (risk of bleed)

PPI with fastest oral absorption
Zegerid
Omeprazole with Sodium Bicarbonate
Prevacid
lansoprazole

caps ER and Solutabs- 15, 30 mg
PO Susp ER granuls- 15, 30 mg
IV powder (inj)- 30 mg
OTC 24 hr capsule- 15 mg

MOA: Proton Pump Inhibitor-acid activated prodrug at pKa <4

commonly used in combination with Amoxicillin or Amoxicillin and Clarithromycin for eradication of H. pylori (PrevPac)
Protonix
pantoprazole

tabs ER, IV, and oral solution- 20, 40 mg

MOA: Proton Pump Inhibitor-acid activated prodrug at pKa <4

PPI with least Drug interactions
Nexium
esomeprazole

caps ER, IV, packets- 20, 40 mg

MOA: Proton Pump Inhibitor-acid activated prodrug at pKa <4

Isomer of Prilosec
Aciphex
Rabeprazole Tabs ER 20 mg

MOA: Proton Pump Inhibitor-acid activated prodrug at pKa <4

Can be taken with or without food
Dexilant
Dexlansoprazole Dr Caps- 30, 60 mg QD

Isomer of Lansoprazole, 2-phase release

MOA: Proton Pump Inhibitor-acid activated prodrug at pKa <4
Carafate
Sucralfate tabs- 1 gram
Sucralfate Susp- 1 gram/ 2tsp

Aluminum Sulfated Sucrose

Use: Duodenal ulcer; GI Band-AID

Good for pregnant patients; no systemic absorption, only local

Counsel: take with water, 60 min before meal; separate from other drugs (Al can chelate); Constipation

Take 1 hr after meal for heart burn
Cytotec
misoprostol tabs- 100, 200 mcg

MOA: Prostaglandin analog that increases GI mucus; mildly blocks acid secretion

Use: Gastric ulcer; decreases risk of NSAID induced gastric ulcers

Taken up to 4 times daily

Unlabeled use: cervical ripening and labor induction; pregnancy termination

Adverse Effect: Diarrhea

Pregnancy (BBW) can induce contractions; Category X
Reglan
metoclopramide

tabs- 5, 10 mg
syrup- 5 mg/ tsp
Injection- 5 mg/ mL

MOA: Ach Agonist (GI prokinetic) and DA Antagonist (Antiemetic); facilitates Ach release from enteric neurons; stimulates GI peristalsis

USE: diabetic gastropersis, symptomatic GERD, N/V

SE: EPS- lip smacking, chewing, tardive dyskinesia and Diarrhea

Caution: CNS depression; Ach agonist w/ DA antagonist effects (CI in Parkinson's patients)

Do NOT take with Librax or Dicyclomine (seperate by a few hours)

ODT= Metozolv 5mg or 10mg
Amitiza
Lubiprostone caps- 8, 24 mcg

MOA: Activates Cl- channels, enhances intestinal fluid secretion

USE: for irritable bowel syndrome with Constipation (IBS-C)
Compazine
prochlorperazine

tabs- 5, 10 mg
SUPP- 25 mg
Injection

Phenothiazine indicated for N/V treatment

MOA: DA and Ach Antagonist

EPS Potential
Tigan
Trimethobenzamide

Caps- 300mg
Inj (IM)

Unkown MOA

Moderately effective

DESI drug (effecacy not proven)
Lomotil
Diphenoxylate/ Atropine Sulfate

tab- 2.5/ 0.025 mg
Liquid- 2.5/ 0.025mg/ tsp

Use: Adjunct tx in the treatment of diarrhea

Narcotic related to meperidine; inhibits peristaliss

C-V Controlled Drug
Zofran
Ondansetron

Tabs- 4, 8 mg
PO soln- 4 mg/ tsp
Inj soln- 2mg/ mL

5-HT3 receptor Antagonist- works peripherally no vagal nerve terminals and centrally in the CTZ
Kytril
Ganisetron

tabs- 1 mg
PO soln- 2mg/ 2 TSP

MOA: Serotonin Antagonist

Sancuso is Granisetron Transdermal System (one patch/ week)

Over $400/ patch

Useful in chemotherapy- associated nausea and vomiting
Asacol
Mesalamine

ER Tabs- 400mg [2 TID] or higher
HD tabs- 800mg

MOA: 5- Amino salicylic acid (local action on gut mucosa. Anti-inflammatory)

Indication: Crohn's , Ulcerative colitis
Pentasa
Mesalamine

CR (ER) Capsules- 250, 500 mg [1 gram QID]

MOA: 5- Amino salicylic acid (local action on gut mucosa. Anti-inflammatory)

Capsule can be opened and sprinkled on food
Rowasa
Mesalamine

PR Susp (Enema)- 4 grams/ 60 mL [HS]

MOA: 5- Amino salicylic acid (local action on gut mucosa. Anti-inflammatory)

Shake well. Lie on LEFT SIDE at HS. Insert PR, retain in rectum 8 hours
CANASA
Mesalamine

Supp- 1000 mg [1 BID]

MOA: 5- Amino salicylic acid (local action on gut mucosa. Anti-inflammatory)

Retain in rectum 1-3 hrs
Lialda
Mesalamine

ER tabs- 1.2 g [2-4 grams QD w/ a meal]

MOA: 5- Amino salicylic acid (local action on gut mucosa. Anti-inflammatory)

Once a day dosage
Dipentum
Mesalamine

Caps (rarely used)- 250mg [4 BID]

MOA: 5- Amino salicylic acid (local action on gut mucosa. Anti-inflammatory)

Two 5-ASA molecules linked by AZO bond. Split by bacteria.

ADR: Diarrhea
Azulfidine
Sulfasalazine

tabs- 500 mg
Entabs- 500 mg

PRODRUG- mesalamine (5-ASA) and sulfapyridine

MOA: acts locally in the colon to decrease the inflammatory response and systematically interferes with secretion by inhibiting prostaglandin synthesis

USE: Ulcerative colitis and lower Crohn's disease

Check for SULFA ALERGY

Take with Water
Colazal
Balsalazide

Caps- 750 mg [3 TID x 8-12 wks]

For ACTIVE ulcerative colitis

PRODRUG of 5-ASA and inert carrier
Entocort E. C.
Budesonide

capsule- 3 mg (corticosteroid, glucocorticoid)

9 mg AM up to 8 weeks, then taper down to 6 mg for 2 weeks before d/c

Crohn's Tx in ileum or ascending colon; anti-inflammatory drug (blocks inflammatory PGs)

Taper down to reduce risk of adrenal insufficiency
Pancreaze or Creon
Pancrelipase

Digestive enzymes: Amylase, lipase, protease

Enzyme replacement tx for cystic fibrosis, chronic pancreatitis, pancreatic insufficiency, malabsorption, etc.

Florida Negative Formulary: Illegal to interchange brand/ generci or brand/brand

Must stay with one manufacturer. MUST ask patient what brand or generic product they are previously used