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23 Cards in this Set
- Front
- Back
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COX 1
COX 2 |
COX 1 - found in BV, stomach and kidney and has protective effects
COX 2 - responsible for inflammation |
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what are the MOA of ASA
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irreversibly acetylates and inactivates COX
irreversible platelet inhibition inhibigt PG causing PERIPHERAL action |
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why may you not see antiinflammatory effects with most of these OTC
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require a dose larger than allowed for OTC therefore need script
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what is ASA analgesic and antiinflammatory dose
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analgesic
650-1000mg q4-6h max 4000mg antiinflammatory 4-6g/day |
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why does ASA prolong bleeding time
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irreversibly inhibits to platelet aggregation
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what are cautions of ASA
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pt w/ ulcers
prolong bleeding time displace drugs from protein binding site (MTX/1st gen sulfonylurea) increase uric acid levels (1-2 g day) |
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who can salicylates not be given to
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pt < 18years recovering from viral infections (chicken pox, flu)
3rd trimester of pregnancy mg salicylates CI in kidney ds na salicylates CI in Na restricted diets (HTN) |
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how does Reye's syndrome occur
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kids < 18yrs old receiving salicylates after recovering from viral infection (flu, pox)
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why do NSAIDs have less GI SE than ASA
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less SE b/c reversibly inhibit platelets unlike ASA which irreversibly inhibit platelets
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what are NSAIDs drug interactions with
anticoagulants antihypertensives diuretics protein binding lithium digoxin |
anticoagulants - increase risk of bleeding
antihypertensives - decrease BP lowering effects since NSAIDs increase BP diuretics - increase chance of renal problems naproxen, ketoprofen are protein bound and can displace other p bound drugs increase digoxin concentration and increase Li levels (decrease renal elimination of Li) |
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what is the adult dose for
analgesic/antipyretic antinflammatory use w/ Ibuprofen (advil, motrin) |
analgesic/antipyretic
>12 years 200-400 mg q4-6 hrs max 1200 mg/day antiinflammatory 400-800 mg 3-4x day |
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what is the pedi dose for ibuprofen (advil, motrin)
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7.5mg/kg/dose
30mg/kg/day max |
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what is adult dose for analgesic/antipyretic and antiinflammatory for Naproxen (aleve)
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analgesic/antipyretic
220 q 8-12h max 660mg/day antiinflammatory 275-550 bid max 1650mg/day for 2 weeks |
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pts of what age can't use naproxen (aleve)
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don't use if <12 years old
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what is the adult dose for
analgesic/antipyretic antinflammatory use w/ ketoprofen (orudis) |
analgesic/antipyretic
12.5 mg q6-8h max 75mg/day antiinflammatory 50-75mg 3-4x day max 300mg/day |
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pts of what age can't use ketoprofen
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don't use if <16 years old
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what is the MOA of caffeine and why is it added to APAP/ASA
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moa - increases absorption of drug and may help pain relief by causing vasoconstriction
added to APAP/ASA b/c increases effectiveness |
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what is the effect of low dose aspirin on men and women as far as risk of heart attack and stroke
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men - low dose ASA decreases risk of 1st HA but doesn't prevent sctroke
women - ASA reduces risk of stroke but only women >65 benefit from fewer HA LOW DOSE ASA BENEFICIAL IN PREVENTING RECURRENT EVENTS IN BOTH MEN AND WOMEN |
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what are the properties of APAP
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analgesic and antipyretic activities equivalent to ASA w/ equivalent doses
NO ANTIINFLAMMATORY ACTION DOES NOT AFFECT URIC ACID SECRETION |
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what is the MOA of APAP
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inhibits PG synthesis but exerts inhibitory effect on PG synthesis centrally
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what is the max daily dosage of APAP
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4g/day
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why are there no GI or renal effects with APAP
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inhibitory effect on PG synthesis is central
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pt with history of ulcers are contraindicated from using and what can you treat them with
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NSAIDs
ASA treat with APAP |
