Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
28 Cards in this Set
- Front
- Back
|
topoisomerase I (non-intercalating)
|
comptothecin (CPT): topotecan, irinotecan
|
|
|
topoisomerase II (non-intercalating)
|
etoposide, teniposide
|
|
|
topoisomerase II (intercalating)
|
doxorubicin, daunorubicin, idarubicin, epirubicin, mitomycin C
|
|
|
hematological cancers (CD52-R target on B cells, T cells, tonsil cells, thymocytes, monocytes, macrophage)
|
humanized Ab = alemtuzumab
|
|
|
hematological cancers (CD20-R target on B cells
|
TKI = rituximab
mouse Ab conjugated with yttrium-90 = Ibritumomab mouse Ab conjugated with iodine-131 = Tositumomab |
|
|
hematological cancers (CD33-R target in myeloid cells)
|
humanized Ab conjugated with toxin = gemtuzumab *WITHDRAWN!!*
|
|
|
CML
|
1st gen multikinase inhibitor (not Src) = imatinib
2nd gen multikinase inhibitor (not Src) = nilotinib 2nd gn multikinase inhibitor (Src OK!) = desatinib |
|
|
ANTI-EGFR mAb TX
|
chimeric Ab = CETUXIMAB
human Ab = PANITUMUMAB |
|
|
ANTI-EGFR TKI TX
|
ERLOTINIB
GEFITINIB *REMOVED FROM US MARKET!* |
|
|
ANTI-HER2/NEU
|
humanized Ab = TRASTUZUMAB
multikinase (HER2 and EGFR) = LAPATINIB |
|
|
ANTI-VGEFR
|
VEGF antagonist (ligand) = bevacuzumab [humanized mAb]
VEGF-R antagonist = sorafenib and sunitinib [multikinase inhibitors] |
|
|
26S proteosome inhibitor
|
small molecule inhibitor = BORTEZOMIB
|
|
|
CLASSIC ALKYLATING AGENTS
|
cyclophosphamide, ifofamide
mechlorethamine, melphalan, chlorambucil, altretamine, thiotepa, busulfan |
|
|
NON CLASSIC ALKYLATING AGENTS
|
dacarbazine (does not cross BBB)
temozolamide (crosses BBB) |
|
|
NITROUREAS AKLYLATING AGENTS
|
carmustine (wafers..crosses BBB)
lomustine streptozocin |
|
|
PLATINUM COMPOUNDS ALKYLATING AGENTS
|
cisplatin
carboplatin oxaliplatin (keep patients warm when administering) |
|
|
LHRH/GnRH agonists
|
luprolide, gonereline
|
|
|
SERMs
|
tamoxifen
raloxifene |
|
|
pure antiestrogen
|
fulvestrant
|
|
|
reversible nonsteroidal aromatase inhibitor
|
anastrozole
letrozole |
|
|
irreverseible steroidal aromatase inhibitor
|
exemestane
|
|
|
antiandrogens
|
bicalutamide
flutamide, nulitamide |
|
|
CYP17 inhibitor
|
ketaconozole
abiraterone (in the works) |
|
|
antimetabolites:
Pyrimidine analogues |
Fluorouracil (5-FU)
Gemcitabine Cytarabine |
|
|
antimetabolites:
Folate antagonists |
Methotrexate
Pemetrexed |
|
|
antimetabolites:
Purine analogues |
Mercaptopurine
Thioguanine Fludarabine |
|
|
antimicrotubules:
taxanes |
paclitaxel
docetaxel |
|
|
antimicrotubules:
vinca alkaloids |
vincristine
vinblastine vinorelbine |
