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28 Cards in this Set

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topoisomerase I (non-intercalating)
comptothecin (CPT): topotecan, irinotecan
topoisomerase II (non-intercalating)
etoposide, teniposide
topoisomerase II (intercalating)
doxorubicin, daunorubicin, idarubicin, epirubicin, mitomycin C
hematological cancers (CD52-R target on B cells, T cells, tonsil cells, thymocytes, monocytes, macrophage)
humanized Ab = alemtuzumab
hematological cancers (CD20-R target on B cells
TKI = rituximab
mouse Ab conjugated with yttrium-90 = Ibritumomab
mouse Ab conjugated with iodine-131 = Tositumomab
hematological cancers (CD33-R target in myeloid cells)
humanized Ab conjugated with toxin = gemtuzumab *WITHDRAWN!!*
CML
1st gen multikinase inhibitor (not Src) = imatinib

2nd gen multikinase inhibitor (not Src) = nilotinib

2nd gn multikinase inhibitor (Src OK!) = desatinib
ANTI-EGFR mAb TX
chimeric Ab = CETUXIMAB

human Ab = PANITUMUMAB
ANTI-EGFR TKI TX
ERLOTINIB

GEFITINIB *REMOVED FROM US MARKET!*
ANTI-HER2/NEU
humanized Ab = TRASTUZUMAB

multikinase (HER2 and EGFR) = LAPATINIB
ANTI-VGEFR
VEGF antagonist (ligand) = bevacuzumab [humanized mAb]

VEGF-R antagonist = sorafenib and sunitinib [multikinase inhibitors]
26S proteosome inhibitor
small molecule inhibitor = BORTEZOMIB
CLASSIC ALKYLATING AGENTS
cyclophosphamide, ifofamide

mechlorethamine, melphalan, chlorambucil, altretamine, thiotepa, busulfan
NON CLASSIC ALKYLATING AGENTS
dacarbazine (does not cross BBB)
temozolamide (crosses BBB)
NITROUREAS AKLYLATING AGENTS
carmustine (wafers..crosses BBB)
lomustine
streptozocin
PLATINUM COMPOUNDS ALKYLATING AGENTS
cisplatin
carboplatin
oxaliplatin (keep patients warm when administering)
LHRH/GnRH agonists
luprolide, gonereline
SERMs
tamoxifen
raloxifene
pure antiestrogen
fulvestrant
reversible nonsteroidal aromatase inhibitor
anastrozole
letrozole
irreverseible steroidal aromatase inhibitor
exemestane
antiandrogens
bicalutamide

flutamide, nulitamide
CYP17 inhibitor
ketaconozole

abiraterone (in the works)
antimetabolites:
Pyrimidine analogues
Fluorouracil (5-FU)
Gemcitabine
Cytarabine
antimetabolites:
Folate antagonists
Methotrexate
Pemetrexed
antimetabolites:
Purine analogues
Mercaptopurine
Thioguanine
Fludarabine
antimicrotubules:
taxanes
paclitaxel
docetaxel
antimicrotubules:
vinca alkaloids
vincristine
vinblastine
vinorelbine