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199 Cards in this Set
- Front
- Back
What is the liquid medium in which materials travel in the blood vessels? |
Blood |
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What are the three main functions of blood? |
1. Transportation 2. Protection 3. Regulation |
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What are the three formed elements found in blood? |
1. Erythrocytes 2. Leukocytes 3. Platelets |
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What makes up the matrix of the blood; a clear, light yellow fluid that makes up a little more than half of the blood volume? |
Plasma |
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What are the three types of plasma proteins? |
1. Albumins 2. Globulins 3. Fibrinogens |
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What is the smallest, most abundant plasma protein that transports solutes and buffers the pH of the plasma? |
Albumin |
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What plasma protein transports solutes and plays a role in clotting and immunity? |
Globulin |
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What are the three types of globulins? |
1. Alpha 2. Beta 3. Gamma |
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What plasma protein is a sticky protein that forms the framework of a blood clot? |
Fibrinogen |
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What are considered toxic end products of catabolism that are also found in the blood plasma? |
Nitrogenous wastes |
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What is the term for the production of blood? |
Hemopoiesis |
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What is the name for the tissues that produce blood cells? |
Hemopoietic tissues |
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What cell type is involved in the production of new blood cells? |
Hemopoietic stem cell |
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What does a Hemopoietic stem cell differentiate into? |
Colony forming unit |
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For granulocyte white blood cell production, what are the three cell types that the colony forming units differentiate into? |
1. Eosinophilic myeloblast |
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For agranulocyte white blood cell production, what are the two cell types that the colony forming units differentiate into? |
1. Monoblast |
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For granulocyte white blood cell production, what are the three cell types that the myeloblasts differentiate into? |
1. Eosinophilic promyelocyte |
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For agranulocyte white blood cell production, what are four cell types that the monoblasts and the lymphoblasts differentiate into? |
1. Promonocyte |
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For granulocyte white blood cell production, what are the three cell types that the promyelocytes differentiate into? |
1. Eoisinophilic myelocyte |
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For granulocyte white blood cell production, what are the three cells that the myelocytes form? |
1. Eosinophil |
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For agranulocyte white blood cell production, what are the four cells that the prolymphocytes promonocytes form? |
1. Monocyte |
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What are the five cell types involved in the production of a red blood cell in order from first cell type to final product? |
1. Hemopoietic stem cell 2. Erythrocyte colony forming unit 3. Erythroblast 4. Reticulocyte 5. Erythrocyte |
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What is the term for the production of red blood cells? |
Erythropoiesis |
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T/F: Mature red blood cells lack a nucleus and mitochondria. |
True |
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What is the main role of red blood cells? |
Transport oxygen |
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What makes up the outer plasma membrane of a mature red blood cell? |
Glycolipids |
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What are the two cytoskeletal proteins that make up the inner surface of a red blood cell; giving it resilience and durability? |
1. Spectrin 2. Actin |
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What are the two things that hemoglobin consists of? |
1. Four globins 2. Four heme groups |
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What part of hemoglobin binds oxygen to ferrous iron, allowing each to carry one molecule of oxygen; total of four oxygen? |
Heme group |
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How long does it take for the formation of a new red blood cell? |
3-5 days |
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What are the four stages involved in the production of a mature red blood cell? |
1. Reduction in cell size 2. Increase in cell number 3. Synthesis of hemoglobin 4. Loss of the nucleus and organelles |
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What is present on the erythrocyte colony forming unit that transform it into a erythroblast? |
Receptors for the hormone erythropoietin |
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Once a erythroblast multiples and synthesizes hemoglobin, what happens to the nucleus, resulting in the formation of a reticulocyte? |
It shrivels up and is discharged from the cell |
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What is the average life cycle of a red blood cell? |
120 days |
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What type of feedback loop maintains the red blood cell count? |
Negative |
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What is the term for an oxygen deficiency in the blood? |
Hypoxemia |
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Where do many red blood cells die in the body? |
Spleen |
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How is hemoglobin disposed of in the body after a red blood cell has died; 4 steps? |
1. Macrophages separate the heme from the globin 2. They change the globin into free amino acids to be used for energy or protein synthesis 3. They remove the iron from the heme and release it into the blood 4. Rest of the heme is converted into biliverdin then into bilirubin |
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Which blood type is the universal donor? |
O- |
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Which blood type is the universal recipient? |
AB+ |
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What type of antigens will a Type A person have? |
A |
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What type of antigens will a Type B person have? |
B |
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What type of antibodies will a Type A person have? |
Anti B |
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What type of antibodies will a Type B person have? |
Anti A |
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What type of antigens will a Type AB person have? |
A B |
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What type of antigens will a Type O person have? |
None |
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What type of antibodies will a Type AB person have? |
None |
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What type of antibodies will a Type O person have? |
Anti A Anti B |
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What white blood cell is a granulocyte that phagocytizes bacteria and releases antimicrobial chemicals? |
Neutrophil |
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What white blood cell is a granulocyte that phagocytizes allergens, is involved in the inflammatory response, and releases enzymes that weaken or destroy parasites? |
Eosinophil |
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What white blood cell is a granulocyte that secretes histamine and heparin, promoting the mobility of other white blood cells by preventing clotting? |
Basophil |
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What white blood cell is an agranulocyte that destroys foreign cells, present antigens to activate other immune system cells, secretes antibodies, and serves in immune memory? |
Lymphocytes |
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What white blood cell is an agranulocyte that turns into macrophages and phagocytizes pathogens? |
Monocyte |
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What are the four steps in the production of platelets? |
1. Hemopoietic stem cells have receptors for thrombopoietin which change them into megakaryoblasts 2. They duplicate their DNA resulting in a megakaryocyte 3. It sprouts proplatelets that protrude through the endothelium into the sinusoid blood 4. Blood flow breaks pieces of them off forming platelets that then travel throughout the bloodstream |
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What are the three ways inappropriate clotting is prevented? |
1. Platelet repulsion 2. Dilution 3. Anticoagulants |
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What are the three steps in hemostasis? |
1. Vascular spasm 2. Platelet plug formation 3. Coagulation |
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What step occurs during hemostasis where vasoconstriction of a broken vessel reduces bleeding? |
Vascular spasm |
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What step occurs during hemostasis where a platelet plug forms as platelets adhere to exposed collagen fibers of the vessel wall, temporarily sealing the break? |
Platelet plug formation |
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What step occurs during hemostasis where a blood clot forms as platelets become meshed in fibrin threads, forming a longer lasting seal and gives the vessel time to repair itself? |
Coagulation |
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What usually makes the endothelium of a blood vessel smooth acting as a platelet repellent, but when injured has collagen fibers that become exposed to the blood, adhering to platelets flowing by? |
Prostacyclin |
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What are the three release factors from platelets undergoing degranulation to promote hemostasis? |
1. Serotonin 2. ADP 3. Thromboxane A2 |
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What is converted from a plasma protein that is considered a sticky protein that adheres to the walls of a vessel sticking platelets and blood to it as they arrive? |
Fibrin |
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What are the three steps in extrinsic mechanism of coagulation? |
1. Damaged blood vessel releases Factor III 2. Factor III combines with Factor VII 3. If calcium is present they bind with it to activate Factor X |
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What are the three steps in intrinsic mechanism of coagulation? |
1. Platelets degranulate and release Factor XII 2. Cascade reaction occurs activating Factor XI, Factor IX, and Factor VIII (in that order) 3. Final Factor X is activated (calcium and pherrous iron must be present) |
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What are the four steps in the completion of coagulation? |
1. Factor X combines with Factor III and Factor V 2. Produces prothrombin activator which is converted into thrombin 3. Thrombin chops ups fibrinogen into fibrin 4. Factor XIII links the strands together creating the framework of a clot |
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What occurs after a clot has formed, pulling the fibrin threads closer together to make the clot more compact? |
Clot retraction |
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What are the five repair steps involved after clot retraction has occurred? |
1. Platelets secrete PDGF stimulating the multiplication of fibroblasts and smooth muscle cells 2. They repair the damaged vessel 3. Fibrous tissue is formed, helping to strengthen and seal the vessel while the repair is being done 4. Fibrinolysis gets rid of the clot after finished repair 5. Factor XII makes kallikrein which makes plasmin, helping to dissolve the clot |
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What type of feedback loop occurs during clotting? |
Positive |
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What are short, thick, branched cells that only have one nucleus surrounded by a mass of glycogen, that join together to form a network through each pair of heart chambers? |
Cardiocytes |
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What does the firing of the SA node excite, causing them to contract? |
Atria |
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Why is it a good thing that once the signal reaches the AV node that it slows down? |
It gives the ventricles time to fill up with blood before they begin to contract |
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Where does ventricular systole begin? |
Apex of the heart |
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Because the ventricular cardiocytes are arranged in a spiral manner, what happens to them once they contract? |
Twist |
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T/F: Cardiocytes only depolarize once they have been stimulated, unlike the cells of the SA node. |
True |
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What type of channels are opened, causing an inflow of these ions which depolarizes the cardiac cell to threshold? |
Sodium |
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What does a prolonged depolarization in cardiac muscle cause? |
Plateau |
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T/F: As long as the action potential is in its plateau, the cardiocytes contract. |
True |
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T/F: An EKG traces a single action potential. |
False: It is a composite recording of all action potentials produced by the nodal and myocardial cells. |
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What is produced on an EKG when a signal from the SA node spreads through the atria and depolarizes them? |
P wave |
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What segment on an EKG represents the time required for impulses to travel from the SA node to the AV node? |
P wave |
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What is produced on an EKG when the signal from the AV node spreads through the ventricular myocardium and depolarizes the muscle? |
QRS complex |
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What segment on an EKG represents the time during which the ventricles contract and eject blood? |
QRS complex |
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What is produced on an EKG when the signal from the ventricles begins to repolarize? |
T wave |
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T/F: The ventricles take longer to repolarize than they do to depolarize. |
True |
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What consists of one complete contraction and relaxation of all four heart chambers? |
Cardiac cycle |
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Where does pressure flow along its gradient? |
Down its gradient |
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What happens to the pressure inside the ventricle as it expands? |
Pressure falls |
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As the ventricle expands, causing a decrease in pressure, what has to be open in order for blood to be able to move into the ventricle? |
AV valve |
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During contraction of a ventricle, what happens to the pressure inside it? |
Pressure rises |
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As pressure rises during contraction of a ventricle, what has to be open in order for the blood to move into the aorta? |
Aortic valve |
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What happens to the AV valve once blood begins rushing into the ventricle below, causing an increase in pressure? |
It is forced closed by the blood so blood does not flow backwards into the atria. |
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What are produced with the closing of the valves as a result of turbulence in the bloodstream and movement of the heart wall? |
Heart sounds |
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What are the four phases of the cardiac cycle? |
1. Ventricular filling 2. Isovolumetric contraction 3. Ventricular ejection 4. Isovolumetric relaxation |
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What are the three steps involved during ventricular filling? |
1. Ventricles expand and their pressure drops below the pressure of the atria 2. AV valves open and blood flows in 3. Pressure inside ventricles increases and atrial pressure decreases
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What are the three phases ventricular filling occurs in? |
1. Rapid filling 2. Diastosis 3. Atrial systole |
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What are the six steps involved during isovolumetric contraction? |
1. Atria repolarize, relax, and remain in diastole for the rest of the cardiac cycle 2. Ventricles depolarize and begin to contract 3. Pressure rises sharply and tries to leave the ventricle back up through the atria 4. AV valves close and first heart sound is heard 5. Pressure in the aorta and semilunar valves are still greater then the ventricles so they oppose the opening of the semilunar valves 6. Ventricles wait to eject blood as their volume remains unchanged |
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What are the three steps involved in ventricular ejection? |
1. Once pressure in the ventricles exceeds arterial pressure blood forces the semilunar valves open 2. Rapid ejection occurs then turns into reduced ejection once under less pressure 3. Ventricles maintain some blood in them |
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What is the term for the amount of blood that fills the ventricles after ventricular filling? |
End diastolic volume |
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What is the term for the amount of blood ejected during ventricular ejection? |
Stroke volume |
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What is the term for the amount of blood that remains in the ventricles after ventricular ejection has occurred? |
End systolic volume |
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What is the formula for finding the end systolic volume? |
End diastolic volume - Stroke volume = End systolic volume |
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What are the three steps involved in isovolumetric relaxation? |
1. Ventricles begin to expand 2. Blood from the aorta and pulmonary trunk flows backward against the semilunar valves causing the second heart sound 3. AV valves are still closed and the ventricles are not taking in any blood |
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What is the term for the amount of blood ejected from each ventricle in one minute? |
Cardiac output |
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What is the difference between the maximum and resting cardiac output? |
Cardiac reserve |
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How is cardiac output determined? |
Heart rate X Stroke volume |
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What is the term for a persistent resting adult heart rate above 100 bmp? |
Tachycardia |
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What is the term for a persistent resting adult rate below 60 bpm? |
Bradycardia |
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What are factors that raise heart rate called? |
Positive chronotropic agents |
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What are factors that lower heart rate called? |
Negative chronotropic agents |
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What are the three variables that govern stroke volume? |
1. Preload 2. Contractility 3. Afterload |
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What is the amount of tension in the ventricular myocardium immediately before it begins to contract? |
Preload |
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T/F: When ventricles contract more forcefully they expel more blood. |
True |
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What principle states that stroke volume is proportional to the end diastolic volume; the more the ventricles are stretched the harder they contract on the next beat? |
Frank-Starling law of the heart |
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What refers to how hard the myocardium contracts for a given preload? |
Contractility |
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What is the term for factors that increase contractility: calcium? |
Positive inotropic agents |
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What is the term for factors that decrease contractility: hyperkalemia? |
Negative inotropic agents |
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What is the sum of all forces a ventricle must overcome before it can eject blood? |
Afterload |
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Where is the most significant contribution from when it comes to the afterload? |
Blood pressure in the aorta and pulmonary trunk distal to the semilunar valves |
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Would scar tissue buildup in the lungs increase or decrease afterload in the pulmonary trunk? |
Increase |
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What type of effects results from sympathetic stimulation, epinephrine and norepinephrine, thyroid hormone, hypocalcemia, and hypercapnia and acidosis? |
Positive chronotropic agents |
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What type of effects results from parasympathetic stimulation, ACH, hyperkalemia, hypokalemia, hyperkalemia, and hypoxia? |
Negative chronotropic agents |
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What type of effects results from sympathetic stimulation, epinephrine and norepinephrine, Hypercalcemia, digitalis, glucagon, and caffeine? |
Positive inotropic agents |
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What type of effects results from hyperkalemia, hypocalcemia, myocardial hypoxia, myocardial hypercapnia, and myocardial acidosis? |
Negative inotropic agents |
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What happens to cardiac output if sympathetic output from the cardiac center increases? |
Cardiac output increases |
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What efferent blood vessel carries blood away from the heart? |
Artery |
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What afferent blood vessel carries blood back to the heart? |
Vein |
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What are microscopic, thin walled vessels that connect the smallest arteries to the smallest veins? |
Capillaries |
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What are the three layers of a blood vessel? |
1. Tunica interna 2. Tunica media 3. Tunica externa |
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Which layer of a blood vessel lines the inside, consists of a simple squamous endothelium overlying a basement membrane, and is exposed to the blood? |
Tunica interna |
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What are the three functions of the tunica interna of a blood vessel? |
1. Selectively permeable barrier 2. Secretes chemicals to stimulate constriction or dilation 3. Repels blood cells and platelets so they don't stick |
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What happens when the endothelium of a blood vessel is damaged? |
Platelets adhere to it and form a blood clot |
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What are formed when the endothelium has an inflammatory response, adhering leukocytes to the surface of the area where they can take action? |
Cell adhesion molecules |
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Which layer of a blood vessel consists of smooth muscle, collagen, and some elastic tissue, strengthens the vessel, and prevents blood pressure from rupturing them? |
Tunica media |
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What is produced by the tunica media that changes the diameter of a blood vessel? |
Vasomotion |
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Which layer is the outermost layer of a blood vessel that consists of loose connective tissue that helps anchor the vessel? |
Tunica externa |
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What are sometimes called the resistance vessels because they are built to withstand ejection from the heart, are more muscular, and retain their shape even after they have emptied? |
Arteries |
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What are known as the biggest arteries that expand during ventricular systole (taking pressure off smaller arteries) and recoil during ventricular diastole (preventing blood pressure from dropping to low during relaxation and refilling)? |
Conducting arteries |
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What happens to conducting arteries overtime that causes them to be less able to expand which puts more pressure on the smaller arteries over time, causing the possibility of developing aneurysms? |
Arteriosclerosis (stiffen) |
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What artery follows a conducting artery and distributes blood to specific organs? |
Distributing arteries |
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What artery follows a distributing artery and branch into arterioles which are the smallest of the arteries? |
Resistance arteries |
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What are short vessels that link arteries and capillaries? |
Metarterioles |
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What are found in the common carotid arteries that act as chemoreceptors to monitor changes in blood composition: stabilize pH? |
Carotid bodies |
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What do arterioles, capillaries, and venules make up? |
Microvasculature |
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What type of capillary occurs in most tissues and is held together by tight junctions? |
Continuous capillaries |
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What structure separates the endothelial cells of a continuous capillary allowing only small solutes to pass through (glucose) and not allowing large molecules to pass through (plasma proteins, platelets, and blood cells)? |
Intercellular cleft |
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T/F: The brain contains intercellular clefts. |
False: They have more complete tight junctions that form the blood brain barrier. |
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What are found outside the capillary that wrap around it and contract, regulate blood flow, and contribute to vessel growth and repair? |
Pericytes |
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What type of capillary consists of a much thinner glycoprotein membrane, allowing for rapid exchange of small molecules, but still retains larger molecules in the bloodstream? |
Fenestrated capillaries |
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What type of capillary is important in organs that engage in rapid absorption and filtration? |
Fenestrated capillaries |
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What type of capillary is an irregular blood filled space in the liver, bone marrow, and spleen that conform to the shape of the surrounding tissue that contain large fenestrations through them allowing for the passage of large molecules, plasma proteins, and blood cells? |
Sinusoid |
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What are capillaries organized into where 10-100 capillaries are supplied by 1 metarteriole? |
Capillary bed |
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True/False: There is not enough blood in the body to fill the entire vascular system at once, at any given time about three quarters of the body's capillaries are shut down? |
True |
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What vessel is also known as the capacitance vessel of the cardiovascular system, because they easily accommodate an increased volume in blood? |
Veins |
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Why are veins so thin walled and accommodating? |
Since they are distant from the ventricles, they are subjected to relatively low blood pressure, and have a steady flow instead of a pulsating one like the hearts have with the heart |
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For arteries, does blood flow from the largest to the smallest artery or the smallest to the largest? |
Largest to the smallest |
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For veins, does blood flow from the largest to the smallest vein or the smallest to the largest? |
Smallest to the largest |
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Which vein is the smallest and receive blood directly from the capillaries or through thoroughfare channels? |
Postcapillary venules |
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Which vein receives blood from the postcapillary venules? |
Muscular venules |
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Which vein receives blood from the muscular venules and account for the regional names of veins in the body: radial and ulnar veins? |
Medium veins |
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What do medium veins contain that help push blood upward against gravity with the help of skeletal muscles: skeletal muscle pump? |
Venous valves |
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What occurs when the venous valves no longer work? |
Varicose veins |
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What veins extend from the medium veins and are not capable of vasomotion because they lack smooth muscle? |
Venous sinuses |
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What veins extend from the venous sinuses and are considered the biggest veins in the body: vena cava and jugular veins? |
Large veins |
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What is the simplest most common route of blood flow: 5 steps? |
1. Heart 2. Arteries 3. Capillaries 4. Veins 5. Heart |
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What occurs when blood flows through two consecutive capillary networks before returning to the heart: only occurs in a few areas of the body? |
Portal system |
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What is the term for the point where two blood vessels merge? |
Anastomosis |
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What occurs when blood flows directly from an artery to a vein and bypasses the capillaries: fingers and toes when we need to bypass heat? |
Arteriovenous anastomosis |
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What is the most common anastomosis in which one vein empties directly into another vein: provides alternative routes of drainage for an organ making blockage less of a threat? |
Venous anastomosis |
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What provides collateral routes of blood supply to a tissue and occurs when two arteries merge: found in joints where movement may compress one pathway? |
Arterial anastomosis |
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What are the two ways blood supply can be expressed? |
1. Flow 2. Perfusion |
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What is the term for the amount of blood flowing through an organ, tissue, or blood vessel in a give time? |
Flow |
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What is the term for the flow per given volume of mass of tissue? |
Perfusion |
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True/False: In a resting human, total flow is constant and equal to cardiac output. |
True |
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True/False: Blood flow through individual organs is usually constant. |
False: It varies from minute to minute as blood is redirected from one organ to another. |
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What is the term for the physical principles of blood flow which are based on pressure and resistance? |
Hemodynamics |
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The greater the pressure difference between two points, the greater the __________. |
Flow |
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The greater the resistance between two points, the less the __________. |
Flow |
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What is the force that the blood exerts against a vessel wall? |
Blood pressure |
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What is the peak arterial pressure attained during ventricular contraction? |
Systolic pressure |
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What is the minimum arterial blood pressure occurring during the ventricular relaxation between heart beats? |
Diastolic pressure |
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What is the difference between systolic pressure and diastolic pressure and measures the maximum stress exerted on small arteries by the pressure surges generated by the heart? |
Pulse pressure |
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What is the term for the mean pressure you would obtain if you took blood pressure measurements at different intervals throughout the cardiac cycle: pulse pressure/3 + diastolic pressure? |
Mean arterial pressure (MAP) |
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What is the term for the growth of lipid deposits in the arterial walls, which become calcified and give the arteries a hard, bonelike consistency? |
Atherosclerosis |
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What is the term for a chronic resting blood pressure higher than 140/90, which can weaken small arteries and cause aneurysms? |
Hypertension |
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What is the term for a chronic low resting blood pressure and is due to anemia, dehydration, and blood loss? |
Hypotension |
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What are the three variables that blood pressure is determined by? |
1. Cardiac output 2. Blood volume 3. Resistance to flow |
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Which organ has the greatest influence on blood pressure because it regulates blood volume? |
Kidneys |
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What is the term for the opposition to flow that the blood encounters in vessels away from the heart? |
Peripheral resistance |
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True/False: A moving fluid has no pressure unless it encounters at least some resistance. |
True |
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Pressure is affected by _________. |
Resistance |
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Flow is affected by __________ and __________. |
Pressure Resistance |
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What are the three variables that affect resistance? |
1. Blood viscosity 2. Vessel length 3. Vessel radius |
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What refers to the thickness of the blood? |
Viscosity |
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Pressure and flow __________ with distance. |
Decline |
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Blood flow is __________ near the center of the vessel where is encounters less friction. |
Faster |
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Blood flow is __________ near the walls of a vessel because it drags against the wall. |
Slower |
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What is the formula for determining blood flow? |
Flow = Radius (to the fourth power) |
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True/False: Blood in the veins regains the velocity it had in the large arteries. |
False: It never does because the veins are farther from the heart. |
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What have the most control over peripheral resistance and blood flow because they are positioned to regulate blood flow into the capillary beds, outnumber all the vessels, and are more muscular in proportion to their size than any other blood vessel? |
Arterioles |