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199 Cards in this Set

  • Front
  • Back

What is the liquid medium in which materials travel in the blood vessels?

Blood

What are the three main functions of blood?

1. Transportation


2. Protection


3. Regulation

What are the three formed elements found in blood?

1. Erythrocytes


2. Leukocytes


3. Platelets

What makes up the matrix of the blood; a clear, light yellow fluid that makes up a little more than half of the blood volume?

Plasma

What are the three types of plasma proteins?

1. Albumins


2. Globulins


3. Fibrinogens

What is the smallest, most abundant plasma protein that transports solutes and buffers the pH of the plasma?

Albumin

What plasma protein transports solutes and plays a role in clotting and immunity?

Globulin

What are the three types of globulins?

1. Alpha


2. Beta


3. Gamma

What plasma protein is a sticky protein that forms the framework of a blood clot?

Fibrinogen

What are considered toxic end products of catabolism that are also found in the blood plasma?

Nitrogenous wastes

What is the term for the production of blood?

Hemopoiesis

What is the name for the tissues that produce blood cells?

Hemopoietic tissues

What cell type is involved in the production of new blood cells?

Hemopoietic stem cell

What does a Hemopoietic stem cell differentiate into?

Colony forming unit

For granulocyte white blood cell production, what are the three cell types that the colony forming units differentiate into?

1. Eosinophilic myeloblast
2. Basophilic myeloblast
3. Neutrophilic myeloblast

For agranulocyte white blood cell production, what are the two cell types that the colony forming units differentiate into?

1. Monoblast
2. Lymphoblast

For granulocyte white blood cell production, what are the three cell types that the myeloblasts differentiate into?

1. Eosinophilic promyelocyte
2. Basophilic promyelocyte
3. Neutrophilic promyelocyte

For agranulocyte white blood cell production, what are four cell types that the monoblasts and the lymphoblasts differentiate into?

1. Promonocyte
2. B prolymphocyte
3. T prolymphocyte
4. NK prolymphocyte

For granulocyte white blood cell production, what are the three cell types that the promyelocytes differentiate into?

1. Eoisinophilic myelocyte
2. Basophilic myelocyte
3. Neutrophilic myelocyte

For granulocyte white blood cell production, what are the three cells that the myelocytes form?

1. Eosinophil
2. Basophil
3. Neutrophil

For agranulocyte white blood cell production, what are the four cells that the prolymphocytes promonocytes form?

1. Monocyte
2. B lymphocyte
3. T lymphocyte
4. NK cell

What are the five cell types involved in the production of a red blood cell in order from first cell type to final product?

1. Hemopoietic stem cell


2. Erythrocyte colony forming unit


3. Erythroblast


4. Reticulocyte


5. Erythrocyte

What is the term for the production of red blood cells?

Erythropoiesis

T/F: Mature red blood cells lack a nucleus and mitochondria.

True

What is the main role of red blood cells?

Transport oxygen

What makes up the outer plasma membrane of a mature red blood cell?

Glycolipids

What are the two cytoskeletal proteins that make up the inner surface of a red blood cell; giving it resilience and durability?

1. Spectrin


2. Actin

What are the two things that hemoglobin consists of?

1. Four globins


2. Four heme groups

What part of hemoglobin binds oxygen to ferrous iron, allowing each to carry one molecule of oxygen; total of four oxygen?

Heme group

How long does it take for the formation of a new red blood cell?

3-5 days

What are the four stages involved in the production of a mature red blood cell?

1. Reduction in cell size


2. Increase in cell number


3. Synthesis of hemoglobin


4. Loss of the nucleus and organelles

What is present on the erythrocyte colony forming unit that transform it into a erythroblast?

Receptors for the hormone erythropoietin

Once a erythroblast multiples and synthesizes hemoglobin, what happens to the nucleus, resulting in the formation of a reticulocyte?

It shrivels up and is discharged from the cell

What is the average life cycle of a red blood cell?

120 days

What type of feedback loop maintains the red blood cell count?

Negative

What is the term for an oxygen deficiency in the blood?

Hypoxemia

Where do many red blood cells die in the body?

Spleen

How is hemoglobin disposed of in the body after a red blood cell has died; 4 steps?

1. Macrophages separate the heme from the globin


2. They change the globin into free amino acids to be used for energy or protein synthesis


3. They remove the iron from the heme and release it into the blood


4. Rest of the heme is converted into biliverdin then into bilirubin

Which blood type is the universal donor?

O-

Which blood type is the universal recipient?

AB+

What type of antigens will a Type A person have?

A

What type of antigens will a Type B person have?

B

What type of antibodies will a Type A person have?

Anti B

What type of antibodies will a Type B person have?

Anti A

What type of antigens will a Type AB person have?

A


B

What type of antigens will a Type O person have?

None

What type of antibodies will a Type AB person have?

None

What type of antibodies will a Type O person have?

Anti A


Anti B

What white blood cell is a granulocyte that phagocytizes bacteria and releases antimicrobial chemicals?

Neutrophil

What white blood cell is a granulocyte that phagocytizes allergens, is involved in the inflammatory response, and releases enzymes that weaken or destroy parasites?

Eosinophil

What white blood cell is a granulocyte that secretes histamine and heparin, promoting the mobility of other white blood cells by preventing clotting?

Basophil

What white blood cell is an agranulocyte that destroys foreign cells, present antigens to activate other immune system cells, secretes antibodies, and serves in immune memory?

Lymphocytes

What white blood cell is an agranulocyte that turns into macrophages and phagocytizes pathogens?

Monocyte

What are the four steps in the production of platelets?

1. Hemopoietic stem cells have receptors for thrombopoietin which change them into megakaryoblasts


2. They duplicate their DNA resulting in a megakaryocyte


3. It sprouts proplatelets that protrude through the endothelium into the sinusoid blood


4. Blood flow breaks pieces of them off forming platelets that then travel throughout the bloodstream

What are the three ways inappropriate clotting is prevented?

1. Platelet repulsion


2. Dilution


3. Anticoagulants

What are the three steps in hemostasis?

1. Vascular spasm


2. Platelet plug formation


3. Coagulation

What step occurs during hemostasis where vasoconstriction of a broken vessel reduces bleeding?

Vascular spasm

What step occurs during hemostasis where a platelet plug forms as platelets adhere to exposed collagen fibers of the vessel wall, temporarily sealing the break?

Platelet plug formation

What step occurs during hemostasis where a blood clot forms as platelets become meshed in fibrin threads, forming a longer lasting seal and gives the vessel time to repair itself?

Coagulation

What usually makes the endothelium of a blood vessel smooth acting as a platelet repellent, but when injured has collagen fibers that become exposed to the blood, adhering to platelets flowing by?

Prostacyclin

What are the three release factors from platelets undergoing degranulation to promote hemostasis?

1. Serotonin


2. ADP


3. Thromboxane A2

What is converted from a plasma protein that is considered a sticky protein that adheres to the walls of a vessel sticking platelets and blood to it as they arrive?

Fibrin

What are the three steps in extrinsic mechanism of coagulation?

1. Damaged blood vessel releases Factor III


2. Factor III combines with Factor VII


3. If calcium is present they bind with it to activate Factor X

What are the three steps in intrinsic mechanism of coagulation?

1. Platelets degranulate and release Factor XII


2. Cascade reaction occurs activating Factor XI, Factor IX, and Factor VIII (in that order)


3. Final Factor X is activated (calcium and pherrous iron must be present)

What are the four steps in the completion of coagulation?

1. Factor X combines with Factor III and Factor V


2. Produces prothrombin activator which is converted into thrombin


3. Thrombin chops ups fibrinogen into fibrin


4. Factor XIII links the strands together creating the framework of a clot

What occurs after a clot has formed, pulling the fibrin threads closer together to make the clot more compact?

Clot retraction

What are the five repair steps involved after clot retraction has occurred?

1. Platelets secrete PDGF stimulating the multiplication of fibroblasts and smooth muscle cells


2. They repair the damaged vessel


3. Fibrous tissue is formed, helping to strengthen and seal the vessel while the repair is being done


4. Fibrinolysis gets rid of the clot after finished repair


5. Factor XII makes kallikrein which makes plasmin, helping to dissolve the clot

What type of feedback loop occurs during clotting?

Positive

What are short, thick, branched cells that only have one nucleus surrounded by a mass of glycogen, that join together to form a network through each pair of heart chambers?

Cardiocytes

What does the firing of the SA node excite, causing them to contract?

Atria

Why is it a good thing that once the signal reaches the AV node that it slows down?

It gives the ventricles time to fill up with blood before they begin to contract

Where does ventricular systole begin?

Apex of the heart

Because the ventricular cardiocytes are arranged in a spiral manner, what happens to them once they contract?

Twist

T/F: Cardiocytes only depolarize once they have been stimulated, unlike the cells of the SA node.

True

What type of channels are opened, causing an inflow of these ions which depolarizes the cardiac cell to threshold?

Sodium

What does a prolonged depolarization in cardiac muscle cause?

Plateau

T/F: As long as the action potential is in its plateau, the cardiocytes contract.

True

T/F: An EKG traces a single action potential.

False: It is a composite recording of all action potentials produced by the nodal and myocardial cells.

What is produced on an EKG when a signal from the SA node spreads through the atria and depolarizes them?

P wave

What segment on an EKG represents the time required for impulses to travel from the SA node to the AV node?

P wave

What is produced on an EKG when the signal from the AV node spreads through the ventricular myocardium and depolarizes the muscle?

QRS complex

What segment on an EKG represents the time during which the ventricles contract and eject blood?

QRS complex

What is produced on an EKG when the signal from the ventricles begins to repolarize?

T wave

T/F: The ventricles take longer to repolarize than they do to depolarize.

True

What consists of one complete contraction and relaxation of all four heart chambers?

Cardiac cycle

Where does pressure flow along its gradient?

Down its gradient

What happens to the pressure inside the ventricle as it expands?

Pressure falls

As the ventricle expands, causing a decrease in pressure, what has to be open in order for blood to be able to move into the ventricle?

AV valve

During contraction of a ventricle, what happens to the pressure inside it?

Pressure rises

As pressure rises during contraction of a ventricle, what has to be open in order for the blood to move into the aorta?

Aortic valve

What happens to the AV valve once blood begins rushing into the ventricle below, causing an increase in pressure?

It is forced closed by the blood so blood does not flow backwards into the atria.

What are produced with the closing of the valves as a result of turbulence in the bloodstream and movement of the heart wall?

Heart sounds

What are the four phases of the cardiac cycle?

1. Ventricular filling


2. Isovolumetric contraction


3. Ventricular ejection


4. Isovolumetric relaxation

What are the three steps involved during ventricular filling?

1. Ventricles expand and their pressure drops below the pressure of the atria


2. AV valves open and blood flows in


3. Pressure inside ventricles increases and atrial pressure decreases


What are the three phases ventricular filling occurs in?

1. Rapid filling


2. Diastosis


3. Atrial systole

What are the six steps involved during isovolumetric contraction?

1. Atria repolarize, relax, and remain in diastole for the rest of the cardiac cycle


2. Ventricles depolarize and begin to contract


3. Pressure rises sharply and tries to leave the ventricle back up through the atria


4. AV valves close and first heart sound is heard


5. Pressure in the aorta and semilunar valves are still greater then the ventricles so they oppose the opening of the semilunar valves


6. Ventricles wait to eject blood as their volume remains unchanged

What are the three steps involved in ventricular ejection?

1. Once pressure in the ventricles exceeds arterial pressure blood forces the semilunar valves open


2. Rapid ejection occurs then turns into reduced ejection once under less pressure


3. Ventricles maintain some blood in them

What is the term for the amount of blood that fills the ventricles after ventricular filling?

End diastolic volume

What is the term for the amount of blood ejected during ventricular ejection?

Stroke volume

What is the term for the amount of blood that remains in the ventricles after ventricular ejection has occurred?

End systolic volume

What is the formula for finding the end systolic volume?

End diastolic volume - Stroke volume = End systolic volume

What are the three steps involved in isovolumetric relaxation?

1. Ventricles begin to expand


2. Blood from the aorta and pulmonary trunk flows backward against the semilunar valves causing the second heart sound


3. AV valves are still closed and the ventricles are not taking in any blood

What is the term for the amount of blood ejected from each ventricle in one minute?

Cardiac output

What is the difference between the maximum and resting cardiac output?

Cardiac reserve

How is cardiac output determined?

Heart rate X Stroke volume

What is the term for a persistent resting adult heart rate above 100 bmp?

Tachycardia

What is the term for a persistent resting adult rate below 60 bpm?

Bradycardia

What are factors that raise heart rate called?

Positive chronotropic agents

What are factors that lower heart rate called?

Negative chronotropic agents

What are the three variables that govern stroke volume?

1. Preload


2. Contractility


3. Afterload

What is the amount of tension in the ventricular myocardium immediately before it begins to contract?

Preload

T/F: When ventricles contract more forcefully they expel more blood.

True

What principle states that stroke volume is proportional to the end diastolic volume; the more the ventricles are stretched the harder they contract on the next beat?

Frank-Starling law of the heart

What refers to how hard the myocardium contracts for a given preload?

Contractility

What is the term for factors that increase contractility: calcium?

Positive inotropic agents

What is the term for factors that decrease contractility: hyperkalemia?

Negative inotropic agents

What is the sum of all forces a ventricle must overcome before it can eject blood?

Afterload

Where is the most significant contribution from when it comes to the afterload?

Blood pressure in the aorta and pulmonary trunk distal to the semilunar valves

Would scar tissue buildup in the lungs increase or decrease afterload in the pulmonary trunk?

Increase

What type of effects results from sympathetic stimulation, epinephrine and norepinephrine, thyroid hormone, hypocalcemia, and hypercapnia and acidosis?

Positive chronotropic agents

What type of effects results from parasympathetic stimulation, ACH, hyperkalemia, hypokalemia, hyperkalemia, and hypoxia?

Negative chronotropic agents

What type of effects results from sympathetic stimulation, epinephrine and norepinephrine, Hypercalcemia, digitalis, glucagon, and caffeine?

Positive inotropic agents

What type of effects results from hyperkalemia, hypocalcemia, myocardial hypoxia, myocardial hypercapnia, and myocardial acidosis?

Negative inotropic agents

What happens to cardiac output if sympathetic output from the cardiac center increases?

Cardiac output increases

What efferent blood vessel carries blood away from the heart?

Artery

What afferent blood vessel carries blood back to the heart?

Vein

What are microscopic, thin walled vessels that connect the smallest arteries to the smallest veins?

Capillaries

What are the three layers of a blood vessel?

1. Tunica interna


2. Tunica media


3. Tunica externa

Which layer of a blood vessel lines the inside, consists of a simple squamous endothelium overlying a basement membrane, and is exposed to the blood?

Tunica interna

What are the three functions of the tunica interna of a blood vessel?

1. Selectively permeable barrier


2. Secretes chemicals to stimulate constriction or dilation


3. Repels blood cells and platelets so they don't stick

What happens when the endothelium of a blood vessel is damaged?

Platelets adhere to it and form a blood clot

What are formed when the endothelium has an inflammatory response, adhering leukocytes to the surface of the area where they can take action?

Cell adhesion molecules

Which layer of a blood vessel consists of smooth muscle, collagen, and some elastic tissue, strengthens the vessel, and prevents blood pressure from rupturing them?

Tunica media

What is produced by the tunica media that changes the diameter of a blood vessel?

Vasomotion

Which layer is the outermost layer of a blood vessel that consists of loose connective tissue that helps anchor the vessel?

Tunica externa

What are sometimes called the resistance vessels because they are built to withstand ejection from the heart, are more muscular, and retain their shape even after they have emptied?

Arteries

What are known as the biggest arteries that expand during ventricular systole (taking pressure off smaller arteries) and recoil during ventricular diastole (preventing blood pressure from dropping to low during relaxation and refilling)?

Conducting arteries

What happens to conducting arteries overtime that causes them to be less able to expand which puts more pressure on the smaller arteries over time, causing the possibility of developing aneurysms?

Arteriosclerosis (stiffen)

What artery follows a conducting artery and distributes blood to specific organs?

Distributing arteries

What artery follows a distributing artery and branch into arterioles which are the smallest of the arteries?

Resistance arteries

What are short vessels that link arteries and capillaries?

Metarterioles

What are found in the common carotid arteries that act as chemoreceptors to monitor changes in blood composition: stabilize pH?

Carotid bodies

What do arterioles, capillaries, and venules make up?

Microvasculature

What type of capillary occurs in most tissues and is held together by tight junctions?

Continuous capillaries

What structure separates the endothelial cells of a continuous capillary allowing only small solutes to pass through (glucose) and not allowing large molecules to pass through (plasma proteins, platelets, and blood cells)?

Intercellular cleft

T/F: The brain contains intercellular clefts.

False: They have more complete tight junctions that form the blood brain barrier.

What are found outside the capillary that wrap around it and contract, regulate blood flow, and contribute to vessel growth and repair?

Pericytes

What type of capillary consists of a much thinner glycoprotein membrane, allowing for rapid exchange of small molecules, but still retains larger molecules in the bloodstream?

Fenestrated capillaries

What type of capillary is important in organs that engage in rapid absorption and filtration?

Fenestrated capillaries

What type of capillary is an irregular blood filled space in the liver, bone marrow, and spleen that conform to the shape of the surrounding tissue that contain large fenestrations through them allowing for the passage of large molecules, plasma proteins, and blood cells?

Sinusoid

What are capillaries organized into where 10-100 capillaries are supplied by 1 metarteriole?

Capillary bed

True/False: There is not enough blood in the body to fill the entire vascular system at once, at any given time about three quarters of the body's capillaries are shut down?

True

What vessel is also known as the capacitance vessel of the cardiovascular system, because they easily accommodate an increased volume in blood?

Veins

Why are veins so thin walled and accommodating?

Since they are distant from the ventricles, they are subjected to relatively low blood pressure, and have a steady flow instead of a pulsating one like the hearts have with the heart

For arteries, does blood flow from the largest to the smallest artery or the smallest to the largest?

Largest to the smallest

For veins, does blood flow from the largest to the smallest vein or the smallest to the largest?

Smallest to the largest

Which vein is the smallest and receive blood directly from the capillaries or through thoroughfare channels?

Postcapillary venules

Which vein receives blood from the postcapillary venules?

Muscular venules

Which vein receives blood from the muscular venules and account for the regional names of veins in the body: radial and ulnar veins?

Medium veins

What do medium veins contain that help push blood upward against gravity with the help of skeletal muscles: skeletal muscle pump?

Venous valves

What occurs when the venous valves no longer work?

Varicose veins

What veins extend from the medium veins and are not capable of vasomotion because they lack smooth muscle?

Venous sinuses

What veins extend from the venous sinuses and are considered the biggest veins in the body: vena cava and jugular veins?

Large veins

What is the simplest most common route of blood flow: 5 steps?

1. Heart


2. Arteries


3. Capillaries


4. Veins


5. Heart

What occurs when blood flows through two consecutive capillary networks before returning to the heart: only occurs in a few areas of the body?

Portal system

What is the term for the point where two blood vessels merge?

Anastomosis

What occurs when blood flows directly from an artery to a vein and bypasses the capillaries: fingers and toes when we need to bypass heat?

Arteriovenous anastomosis

What is the most common anastomosis in which one vein empties directly into another vein: provides alternative routes of drainage for an organ making blockage less of a threat?

Venous anastomosis

What provides collateral routes of blood supply to a tissue and occurs when two arteries merge: found in joints where movement may compress one pathway?

Arterial anastomosis

What are the two ways blood supply can be expressed?

1. Flow


2. Perfusion

What is the term for the amount of blood flowing through an organ, tissue, or blood vessel in a give time?

Flow

What is the term for the flow per given volume of mass of tissue?

Perfusion

True/False: In a resting human, total flow is constant and equal to cardiac output.

True

True/False: Blood flow through individual organs is usually constant.

False: It varies from minute to minute as blood is redirected from one organ to another.

What is the term for the physical principles of blood flow which are based on pressure and resistance?

Hemodynamics

The greater the pressure difference between two points, the greater the __________.

Flow

The greater the resistance between two points, the less the __________.

Flow

What is the force that the blood exerts against a vessel wall?

Blood pressure

What is the peak arterial pressure attained during ventricular contraction?

Systolic pressure

What is the minimum arterial blood pressure occurring during the ventricular relaxation between heart beats?

Diastolic pressure

What is the difference between systolic pressure and diastolic pressure and measures the maximum stress exerted on small arteries by the pressure surges generated by the heart?

Pulse pressure

What is the term for the mean pressure you would obtain if you took blood pressure measurements at different intervals throughout the cardiac cycle: pulse pressure/3 + diastolic pressure?

Mean arterial pressure (MAP)

What is the term for the growth of lipid deposits in the arterial walls, which become calcified and give the arteries a hard, bonelike consistency?

Atherosclerosis

What is the term for a chronic resting blood pressure higher than 140/90, which can weaken small arteries and cause aneurysms?

Hypertension

What is the term for a chronic low resting blood pressure and is due to anemia, dehydration, and blood loss?

Hypotension

What are the three variables that blood pressure is determined by?

1. Cardiac output


2. Blood volume


3. Resistance to flow

Which organ has the greatest influence on blood pressure because it regulates blood volume?

Kidneys

What is the term for the opposition to flow that the blood encounters in vessels away from the heart?

Peripheral resistance

True/False: A moving fluid has no pressure unless it encounters at least some resistance.

True

Pressure is affected by _________.

Resistance

Flow is affected by __________ and __________.

Pressure


Resistance

What are the three variables that affect resistance?

1. Blood viscosity


2. Vessel length


3. Vessel radius

What refers to the thickness of the blood?

Viscosity

Pressure and flow __________ with distance.

Decline

Blood flow is __________ near the center of the vessel where is encounters less friction.

Faster

Blood flow is __________ near the walls of a vessel because it drags against the wall.

Slower

What is the formula for determining blood flow?

Flow = Radius (to the fourth power)

True/False: Blood in the veins regains the velocity it had in the large arteries.

False: It never does because the veins are farther from the heart.

What have the most control over peripheral resistance and blood flow because they are positioned to regulate blood flow into the capillary beds, outnumber all the vessels, and are more muscular in proportion to their size than any other blood vessel?

Arterioles