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5 Cards in this Set
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In the case (1) with the px who had atopic dermatitis(red, itchy skin), widespread erythema, exudate from plaques, and severe itching, what immune mediators were the cause?
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Cysteinyl leukotrienes (LTC4, LTD4, LTE4)
Plus histamine and leukotrienes released from IL3 stimulated basophils |
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Whats a SCORAD?
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Severity Scoring Atopic Dermatitis index that measures the severity of AD, and how effective the treatment was
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What treatment was suggested for AD?
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Montelukast (as a cysteinyl leukotriene rx antagonist)
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What drug(s) are typically used to treat AD, and whats their MoA?
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Corticosteroids (such as 6-methylprednisolone), and a topical emolient.
Corticosteroids inhibit PLA2 (and therefore the arachadonic acid pathway), so no leukotrienes or prostaglandins. They also inhibit transcription factors which dec's histamine production. |
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