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20 Cards in this Set
- Front
- Back
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Whats the MoA of Flucytosine?
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Flucytosine inhibits both DNA and RNA synthesis in fungi
Flucytosine is converted into 5-FdUMP which inhibits thymidylate synthase which converts dUMP to dTMP(the T/thymidine in gcaT) |
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What is the MoA of Flucytosine resistance?
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Down regulation of fungal permease which normal takes flucytosine into the cell
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Whats the MoA of allyamines?
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They inhibit squalene epoxidase in the ergosterol pathway
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What are the subclasses of azoles? Which subclasses are topical and which systemic?
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Imidazoles(mostly topical)
Triazoles(mostly systemic) |
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Which imidazole comes in a topical and systemic?
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Ketoconazole
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Which triazole is topical?
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Terconazole
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List 3 imidazoles
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Ketoconazole
Clotrimazole Miconazole |
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List 3 systemic triazoles
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Fluconazole
Itraconazole Voriconzole |
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Whats the MoA of the azoles?
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They inhibit CYP 450 14alpha-demethylase in the ergosterol pathway (further downstream that the allyamines)
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What is the MoA of resistance to the azoles?
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mutation of CYP 450 14alpha-demethylase
upregulation of efflux pumps |
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Which azole(s) can cause a dec in corticosteroid synthesis when given in higher doses?
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Ketoconazole
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Which azole(s) can cause inotropy due to its active metabolite?
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Itraconazole
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Which azoles can be used for fungal meningitis, and why?
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Fluconazole
Voriconazole They're both fluorinated which helps them cross into the CSF |
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Which azole can prolong the QTc interval and causes vision changes in 30% of patients?
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Voriconazole
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Whats the MoA of the echinocandins?
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They inhibit fungal enzyme 1,3 beta glucan synthase, dec'ing synthese of the beta glucan strands in the fungal cell wall
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What do the echinocandins have in common regarding their clinical use?
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They're all IV and reserved use
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What are the AEs of echinocandins?
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Injection site reactions
Elevation of liver enzymes |
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Which antifungal is mainly for dermatophytes(superficial skin infections), but not for non-skin infections like candida or aspergillus?
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Griseofulvin
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Whats the MoA of Griseofulvin?
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Binds to fungal tubulin and inhibits mitosis
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Whats the MoA for Ciclopirox?
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Inhibits bacterial AND fungal membrane transport
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