P2 Skills Fall 2008 Drug Quiz #3

Front 1

What is Generic of Lipitor

Back 1

Atovastatin

Front 2

Dosage forms of lipitor

Back 2

10mg, 20mg, 40mg and 80mg

Front 3

What are indications of Liptor

Back 3

as an adjunt to diet to reduce TC, LDL, ApoB adn TG's elvel and increase HDL levels

Front 4

What type of patients are treated in Liptior

Back 4

primary hyperchosteroemia, mixed dsylipidemai, elevate TGs, and primary dysbetalipoproteinemia, in boys and post menarchal girls

Front 5

What is the dosage range of Lipitor

Back 5

10-80mg once a day at anytime

Front 6

MOA of Lipitor,

Back 6

competitive inhbitor of HMG-CoA reductase, rate limiting step in cholesterol synthesis, increase LDL receptors decrease LDL blood levels

Front 7

Contraindications of Liptior

Back 7

Pregancy/lactation and pts with ACTIVE liver disease and unexaplined persistent elevation fo serum transaminases

Front 8

Common Side effects of Liptior

Back 8

constipation, dyspepsia, and muscle pain (rare)

Front 9

What is generic of Zocor

Back 9

Simvastatin

Front 10

Dosage forms of Zocor

Back 10

5, 10, 20, 40, 80

Front 11

Indication of Zocor

Back 11

ad an adjunct to diet to recuetal TC, LDL Apo B and Tg's and icnreae HDL

Front 12

Pts Zocor treats

Back 12

primary hypercholesterolemai, mixed dyslipdiemai, hypertrigleceredemia nd dysbetalopteinmia, boys and post menarche girls

Front 13

Zocor is typically beiun after 3-6 weeks week cholestrol lowering diet, dose

Back 13

5-80 mg once daily in evening

Front 14

Can Zocor also be dosge 80mg daily in 2 or 3 divided doses

Back 14

YES

Front 15

Zocor is a pro-drug, MOA

Back 15

inhibitor of HMG-CoA reductase (does not completly block)

Front 16

Contraindication of Zocor

Back 16

pregnacy or lactation or pts with active liver disease or unexplained presisstent elevation of serum transaminases

Front 17

Common side effects of Zocor

Back 17

constipation, muscle pain, and dyspepside

Front 18

What is generic of Pravachol

Back 18

Pravastatin

Front 19

Dosage forms of Pravachol

Back 19

10, 20, 40, 80

Front 20

Indications of Pravachol

Back 20

as an adjunt to diet for reduction of TC, LDL, apo B and TG, and increae HDL

Front 21

Typical dosage of Pravachol

Back 21

10-40 in the evening

Front 22

What drugs are dosed at night

Back 22

simvaststin and pravastatin

Front 23

MOA of Pravacol

Back 23

inhibitior of HMG-CoA (do not completly block

Front 24

Contraindications of Pravacol

Back 24

pregnacy and lactation and in pts with active liver disease or unexamplied persisten elevation of serum transaminases

Front 25

Common side effects of pravacol

Back 25

Rash, muscle pain, HA, and influenza

Front 26

What is generic of Crestor

Back 26

Rosuvastatin

Front 27

Dosage forms of Crestor

Back 27

5, 10, 20, 40

Front 28

Indications of Crestor

Back 28

adjuctive to diet, to reduce TC, LDL ApoB, TG, and increase HDL

Front 29

Typical adult dosing of Crestor

Back 29

5-40mg once daily

Front 30

MOA of Crestor

Back 30

Selective competive inhibitor of HMG-CoA reductase, and also increase the number of LDL receotr increase uptake and catabolism of LDL

Front 31

Contraindications of Crestor

Back 31

Pregancy, lactation, and Active liver disease or unexplained presisttent elevation sof serum transaminases

Front 32

Common Side effects of Crestor

Back 32

Musle aipin, constipation, adb pain, and nausea, astehnia

Front 33

What are the 4 HMG-CoA reductase inhibtiors

Back 33

Liptior, Crestor, Zocor, and Pravacol

Front 34

What is generic of Lopid

Back 34

Gemfibrozil

Front 35

Dosage form of Lopid

Back 35

600mg

Front 36

Indication of Lopid

Back 36

pts with Type 4 or V hyperlipidiema with risk of pancreattis,or pts with high LDL of low HDL do not respond to other agents

Front 37

Adult dosing of Lopid

Back 37

600mg BID 30 minutes prior to morning and evening meal

Front 38

MOA of Lopid (general)

Back 38

Decrease TG and VLDL and increase HDL

Front 39

How does Lopid reduce TGs

Back 39

decrease TGs by inhibition of peripheal lipolysis and reduces extraction of FFA

Front 40

How Does Lopid reduce VLDL

Back 40

due to inhibtion of VLDL carrier APOB

Front 41

Contraindication of Lopid

Back 41

Pts with Hepatic or Renal dysfuction and preexisting gallbladder disease

Front 42

Side Effects of Lopid

Back 42

Dyspepsia, abd pain, and diarrhea

Front 43

What is generic of Tricor

Back 43

Fenofibrate

Front 44

Dosage Forms of Tricor, and typical dosing

Back 44

48mg and 145 mg (once daily

Front 45

Indications of Tricor

Back 45

adjucntive therapy to diet to reduce LDL TC, TG ApoB and increase HDL (also treat hyertrigceredemia)

Front 46

Is Tricor recommended with meals

Back 46

YES

Front 47

How does Tricor lower TC LDL and TG's

Back 47

ativation of PPARa

Front 48

What does activation of Peroxisome proliferator recetor alpha do

Back 48

activates LPL and reductio production fo APO CII

Front 49

Contraindcations of Tricor

Back 49

Hepatic or severe rendal dysfuction , gall bladder diseases and pimart vilairy cirrhosis