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25 Cards in this Set
- Front
- Back
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Pegfilgrastim brand name, indication, and dosage form?
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•Neulasta
•For chemo patients with fever, to reduce risk of infection •SubQ injection |
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Pegfilgrastim contains what?
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recombinant methionyl human G-CSF + monomethoxyPEG
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Pegfilgrastim is produced how?
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By E. Coli with plasmid contianing G-CSF gene
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Etanercept brand name, indication, and dosage form?
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•Enbrel
•For RA, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis •SubQ injection |
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Etanercept contains what?
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•A dimer made up of the ligard binding part of TNF-R + the Fc part of human IgG1
•Its a TNF inhibitor |
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Etanercept is produced how?
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By recombinant DNA added to a Chinese hamster ovary (CHO)
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Factor VIII Complex brand name, indication, and dosage form?
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•Monoclate-P
•For hemophilia A •Lyophilized powder for injection |
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Factor VIII Complex is produced how?
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•Made from pooled human plasma using MAb to dissociate the vWf(Ag) from Factor VIII Complex
•Albumin is added as a stabilizer |
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Insulin Lispro USP (rDNA origin) brand name, indication, and dosage form?
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•Humalog
•Anti-diabetic (lowers glucose level) •Injection (of dissolved zinc insulin crystals) |
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Insulin Lispro is produced how?
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•Recombinant non pathogenic E. Coli.
•Its an analog (Lys-28 and Pro-29 are switched) •HCL and/or NaOH added as a buffer |
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Whats Pegylation?
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Attaching PEG to a peptide or Ab to:
•inc its retention in the body •inc its affinity to certain cell receptors •inc its MW |
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What does the inc in MW impart to pegylated drugs?
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•Inc solubility, stability, retention in body
•Dec proteolytic degradation, dosage freq •Opens up new delivery routes and dosing regimens •Can extend the patent (as a different form of drug) |
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List examples of pegylated drugs
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•Pegasys
•PEG-intron •Oncaspar •Neulasta •Doxil |
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Pegasys indication and molecule?
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•For hep-C
•alpha-interferon |
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PEG-intron indication and molecule?
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•For hep-C
•alpha-interferon |
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Oncaspar indication and molecule?
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•For acute lymphoblastic leukemia (and hypersens to non peg L-asparaginase)
•L-asparaginase |
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Neulasta indication and molecule?
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•For neutropenia (from chemotherapy)
•G-CSF |
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Doxil indication and molecule?
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•For cancer (Sequus)
•liposomal doxorubicin |
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GHOSE: An Ab prep containing many Abs, each recognizing a different epitope?
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polyclonal Ab
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GHOSE: An Ab prep generated by a hybrid, immortilized cell?
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Monoclonal Ab.
(hybridomas always make MAb) |
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GHOSE: An Ab prep containing many Abs, where each is identical?
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monoclonal Ab
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GHOSE: An Ab made of mouse variable H and L chains, fused to human constant H and L chains?
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Chimeric or humanized Ab
(wiki: technically there's a difference: humanized just has variable tips of mouse, while chimeric has full variable regions of mouse) |
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GHOSE: An Ab prep harvested from plasma of a human, rabbit, goat, donkey?
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polyclonal Ab
(from any mammalian cell) (me: i guess humoral Ab from an immunization is rarely monclonal) |
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GHOSE: What test uses an enzyme to visually detect sub-microscopic reactions?
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ELIZA (Ab+chromogenic enzyme)
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Most non invasive way to sterilize proteins?
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Filtered sterilization
(uses different pore sizes that filter out bacteria) |
