P031 Pham Basis Of The Treatment Of Depression And Bipolar Disorders

Front 1

The monoamine hypothesis hypothesises that depression is caused by a lack of what three things in the brain?

Back 1

NA, 5-HT and possibly dopamine

Front 2

Give an example of a group of inhibitors that increase the amount of NT released from the nerve terminals?

Back 2

MAO inhibitors (remember, MAO breaks down NT once it has re-entered the nerve)

Front 3

Give an example of a non-selective MAO inhibitor

Back 3

Phenelzine

Front 4

Give an example of a MAO-A inhibitor

Back 4

Maclobemide

Front 5

Give an example of a MAO-B inhibitor

Back 5

Selegiline

Front 6

MAO-B inhibitors are used to treat depression T/F

Back 6

False! Inhibition causes nasty cardiovascular effects. Even non-specific inhibitors have the problem of the 'cheese reaction' re: tyramine

Front 7

Is a tricyclic antidepressant an inhibitor of NT breakdown or an uptake inhibitor?

Back 7

Uptake inhibitor!

Front 8

Give an example of a tricyclic uptake inhibitor?

Back 8

Imipramine

Front 9

Name a selective NA uptake blocker

Back 9

Maprotiline

Front 10

Name a selective 5-HT reuptake inhibitor (SSRI)

Back 10

Fluoxetine

Front 11

Give an example of a serotonin noradrenaline reuptake inhibitor (SNRI) (which inhibits uptake of NA AND 5-HT)

Back 11

Venlafaxine

Front 12

What effect can tricyclic antidepressants have on bipolar disorder?

Back 12

Tricyclic antidepressants can trigger BPD!