P Lizer Lecture 1

Front 1

What are the 5 axes of the DSM-IV-TR?

Back 1

I - primary psych diagnosis
II - personality and developmental disorders
III - physical or general medical disorder
IV - psychological stressors
V - global assesment of functioning (GAF)

Front 2

What does a GAF score of 61-70 represent?
41-50?
11-20?

Back 2

Mild sx

Serious sx

Danger of hurting self or others

Front 3

Components of the AMSIT Mental Status Exam?

Back 3

Appearance, behavior & speech
Mood and affect
Sensorium
Level of Intellectual functioning
Thought process

Front 4

Rating scale for schizophrenia?

Back 4

Brief Psychiatric Rating Scale (BPRS)

Front 5

Rating scale for mood disorders?

Back 5

Beck Depression Inventory (BDI), Hamiltion Depression Rating Scale (HAMD)

Front 6

Rating scale for anxiety?

Back 6

Hamiltion Anxiety Rating Scale (HAMA)

Front 7

Rating scale for dementia?

Back 7

MMSE

Front 8

Rating scale for OCD?

Back 8

Yale-Brown Obsessive Compulsive Scale (YBOCS)

Front 9

Rating scale for tardive dyskinesia?

Back 9

Abnormal Involuntary Movement Scale (AIMS)

Front 10

Fx of cerebrum's frontal lobe?

Back 10

personality, memory, reasoning, concentration...Alzheimer's, depression, mania

Front 11

Fx of cerebrum's parietal lobe?

Back 11

Sensory processing...Alzheimer's

Front 12

Fx of cerebrum's occiptal lobe?

Back 12

visual recognition

Front 13

Fx of cerebrum's temporal lobe?

Back 13

speech, written/verbal/visual cueing...Alzheimer's, depression, mania

Front 14

Disease associated with cerebral cortex?

Back 14

Huntington's

Front 15

Disease associated with basal ganglia?

Back 15

Parkinson's

Front 16

Disease associated with limbic system?

Back 16

Alzheimer's

Front 17

Where do ACh tracts begin?

Back 17

cell bodies at base of frontal lobe

Front 18

Enzymes that break down ACh?

Back 18

acetylcholinesterase & butyrlcholinesterase

Front 19

Where do NE tracts begin?

Back 19

locus coeruleus

Front 20

Enzyme that breaks down NE?

Back 20

COMT and MOA

Front 21

Location of ALPHA 1 receptors?

Back 21

brain, heart, smooth muscle

Front 22

Effects of ALPHA 1 agonism?

Back 22

increased NE, increased BP, vasoconstriction, orgasm, tachycardia

Front 23

Examples of ALPHA 1 agonist?

Back 23

NE, epi, phenylepherine, Sudafed

Front 24

Effects of ALPHA 1 antagonism?

Back 24

decreased NE, decreased BP with reflex tachycardia

Front 25

Examples of ALPHA 1 antagonists?

Back 25

prazosin, TCAs, chlorpromazine

Front 26

Location of ALPHA 2 receptors?

Back 26

brain, pancreas, smooth muscle

Front 27

Effects of ALPHA 2 agonism?

Back 27

inhibits NE release, decreased BP

Front 28

Example of ALPHA 2 agonist?

Back 28

clonidine

Front 29

Effects of ALPHA 2 antagonists?

Back 29

block autoreceptors and increase NE

Front 30

Example of ALPHA 2 antagonist?

Back 30

yohimbine

Front 31

Location of BETA 1 receptors?

Back 31

heart, brain

Front 32

Effects of BETA 1 agonism?

Back 32

increased HR

Front 33

Examples of BETA 1 agonists?

Back 33

epi, dobutamine, isoproterenol

Front 34

Location of BETA 2 receptors?

Back 34

lungs, brain, skeletal muscle

Front 35

Effects of BETA 2 agonism?

Back 35

bronchodilation, uterine muscle contraction, increased blood sugar, vasodilation

Front 36

Effects of BETA 1 and 2 antagonists?

Back 36

decreased BP and HR, peripheral vasoconstriction

Front 37

Example of BETA antagonists?

Back 37

propranolol

Front 38

Effects of H1 receptors in hypothalamus?

Back 38

inhibit appetite, increase wakefulness, motion sickness, vertigo

Front 39

Anxiety and depression related to what histamine receptor family?

Back 39

1A

Front 40

Migraine related to what histamine receptor family?

Back 40

1D

Front 41

Hallucinations related to what histamine receptor family?

Back 41

2B

Front 42

Appetite related to what histamine receptor family?

Back 42

2C

Front 43

Peristalsis related to what histamine receptor family?

Back 43

4

Front 44

Where do serotonin tracts begin?

Back 44

raphe nuclei cell bodies

Front 45

Serotonin involved in?

Back 45

emotions, cognition, sleep, appetite, sexual behavior, CV, cranial vessels

Front 46

Sx of serotonin deficiency?

Back 46

depression, obsession, compulsion, anxiety, panic, phobias, food cravings, aggression

Front 47

Sx of serotonin excess?

Back 47

anxiety, insomnia, GI disturbances, cardiac valve dysfunction

Front 48

Sx of serotonin syndrome?

Back 48

fever, tremor, coma, seizures, death

Front 49

Sx associated with decreased dopamine?

Back 49

parkinson's, decreased attention, hypersomnia, cravings, anhedonia, psuedodementia

Front 50

Sx associated with dopamine overactivity?

Back 50

pyschosis, schizophrenia

Front 51

4 Tracts of Dopamine and their Fx

Back 51

Nigrostriatal: movement
Tuberinfundibular: prolactin release
Mesolimbic: memory, emotion
Mesocortical: emotion, social function

Front 52

Effects of GABA-a stimulation?

Back 52

Cl influx, hyperpolarization, decreased cell excitability

Front 53

Defect with decreased ACh?

Back 53

Alzheimer's

Front 54

Defect with increased Dopamine?

Back 54

schizophrenia

Front 55

Defect with decreased Dopamine?

Back 55

Parkinson's, substance abuse

Front 56

Defect with decreased NE?

Back 56

depression

Front 57

Defect with decreased serotonin?

Back 57

depression, OCD

Front 58

Defect with decreased GABA?

Back 58

Anxiety

Front 59

Defect with increased Glutamate?

Back 59

bipolar, psychosis from neurotoxicity