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28 Cards in this Set
- Front
- Back
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What is the desirable range for LDL?
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<100
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What is the desirable range of HDL?
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>40
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What is the near optimal level of LDL?
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100-129
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What is the desirable level for TG?
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<150
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What is the borderline high level for LDL?
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130-159
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What is the borderline high level for TG?
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150-199
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What is the high level for LDL?
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160-189
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What is the very high level for LDL?
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>190
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What is the very high leve for TG?
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>500
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What is the high level for TG?
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200-499
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What the non-medicinal treatments of hypercholesterolemia?
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reduction in dietary cholesterol, wt loss, and exercise
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What is the first line drug for hypercholesterolemia?
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statins
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What are the non-medicinal treatments for hypertriglycerides?
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low fat diets, exercise
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What is the first line drug for hypertriglycerides?
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fibrates, niacin
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How do statins work?
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inhibit HMG-CoA Reductase because they are HMG-CoA reductase
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What are the three statins broken down by CYP3A4?
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Simvastatin, Atorvastatin, Lovastatin
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Which statins are degraded by CYP2C9?
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Fluvastatin, rosuvastatin
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Which statin would you use with a pt on verapamil?
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provastatin
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Who would you prescribe statins for?
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pregnant, kids, teens, liver dx, familial hypercholesterermia
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What is the second line drug for hyperlipidemia?
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bile acid-binding resins
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How do bile acid-binding resins work?
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bind neg charged bile salt preventing reabs--inc in chol-7-hydroxylase--inc bile acid synthesis--lowers liver chol--inc LDL R
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What besides hyperlipidemia can bile acid-binding resins be used for?
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relieve pruritus
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What is niacin used for?
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lower TG
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What is the MOA of ezetimibe?
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blocks chol abs, dec chol in liver, inc LDL r
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What is the MOA of niacin?
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inhibit lipolysis, inc 1/2 life of apoA1-inc HDL, dec Lp(a), dec LDL
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What are the ADR of niacin?
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GI distress, peptic ulcer exacerbation, gluc intolerance, urecemia
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What drug is good at inc HDL because of an inc in apoAI and apoAII?
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fibrates
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Which fibrate do you use with statins?
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fenofibrate because gemfibrozil inc statin concentration
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