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12 Cards in this Set
- Front
- Back
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A patient comes in with complains of headache, disorientation. She also complaines of ringing in the ears and vision seems blurry. She suddenly vomits and drops to the floor. she is being treated for arrhytmia. Which drug could she be taking?
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Quinidine is a class Ia which may cause asystole, nausea anorexia vomiting and cinchonism (due to atropine like effect)
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Procainamide
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class IA drug
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what is N acetylprocainamide
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it's the metabolite of procainamdie produced in liver. It prolongs the duration of the actionpotential
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A man calls to the psychiatric ward. his wife has been trying to kill him. From being normal, she has rapidly deterioted. On further questioning he respond that she has gradually become more depressed, had hallucinations since 4 weeks ago. He also notices a red rash on the face in form o a buttterfly. On further questioning about medication, he admits she started taking a new drug orally for for her heartproblems because the previous one was making her vomit. What medication could she be taking?
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Procainamide, a class IA drug can give the sideffects mentioned
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How does disopyramide work
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it's a classIA antiarrhytmic with negative inotropic effect. It also cause vasoconstriction. this decrease heart contractibility.
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What is the metabolite of disopyramide
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this class IA antiarrhytmic drug is converted to mono-N-dealkylated
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What is the reason for the advese effects of disopyramide i.e dry mouth, urinary retention, blurred vision and constipation?
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It has anticholinergic activity
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Lidocainne
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Class IB antiarrhytmic- rapidly dissociate from sodium channels
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what can lidocaine be used for
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to treat acute ventricular tachycardia and fibrillation, especially in patients with MI
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why is Lidocaine given IV?
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It undergo extensive first pass metabolism by liver.-dealkylated
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What is the mechanism of action of class IB drugs
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they shorten phase 3 repolarization, decrease duration of action potential
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Which two systems are mainly affected adversely with lidocaine
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This class IB antiarrhytmic affect CNS and heart
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