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14 Cards in this Set
- Front
- Back
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Oxytocin MOA |
Synthetic version of naturally occurring hormone oxytocin, which is norm released from pituitary gland. Stimulates oxytocin receptors on the uterus, causing increased uterine contraction and reduction in uterine blood loss. |
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Oxytocin INDICATIONS |
Following normal birth.
PPH. N.B. Primary PPH = <24hrs after birth Secondary PPH= <6 weeks |
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Oxytocin CONTRAINDICATIONS |
Known severe Ax. |
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Oxytocin CAUTIONS |
None. |
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Oxytocin IN PREGNANCY |
Safe and should be administered. |
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Oxytocin DOSAGE |
10 units. |
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Oxytocin ADMINISTRATION |
IM. Lat thigh. If multiple babies are present administration must occur after the delivery of the LAST baby. If 10 units has been administered as part of routine tx following norm birth, additional 10 for PPH if this develops. |
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Oxytocin ADVERSE EFFECTS |
1. Abdo cramps. 2. Tachycardia. 3. Flushing. |
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Oxytocin ONSET |
5-10 mins. |
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Oxytocin DURATION |
30-60 mins. |
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Oxytocin PREPARATION |
Ampoule with 10 units in 1 ml. |
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Oxytocin PHARMACOKINETICS |
Metabolised in the liver and kidneys. No significant effects from liver or kidney impairment on acute administration. |
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Oxytocin INTERACTIONS |
None. |
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Oxytocin ADDITIONAL INFO |
When it is not refrigerated it loses its activity and therefore is labeled with a discard date 3 months after removal from fridge. Routine administration of oxytocin following norm birth is controversial, but appears to reduce incidence of PPH. Can prolong QT but usually associated with prolonged IV infusions. Ok in 1 or 2 IM doses. NOT TO BE ADMINISTERED IV unless instructed by LMC/doctor. IV is given via infusion, IV boluses can cause hypotension. E.g. Commonly 10-40 units in 1l bag of NaCl and administered over 1-2 hrs. |
