Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

50 Cards in this Set

  • Front
  • Back
In a leukemia, the neoplastic cells are mainly in the ___ and ____?
As opposed to lymphoma, where the cells are in the ____ and ____?
blood & bone marrow

lymph nodes & tissues

You CAN'T differentiate btwn a leukemia and lymphoma clinically (by symptoms alone).
How do you differentiate btwn an indolent and aggresive neoplasm?
Use marker studies

What is an example of an indolent myeloid neoplasm?

an aggressive one?
a myeloproliferative disorder such as chronic myelogenous leukemia (CML)

Acute Myeloid Leukemia
What is an example of an indolent lymphoid neoplasm?

an aggressive one?
low grade lymphoma

high grade lymphoma
What is a plasma cell tumor called?
Multiple Myeloma
What is a neoplasm of the pro-B cells involved (less differentitated)?
Acute LymphoBLASTIC Leukemia
When classifying a neoplasm, calling it a Precursor means what?
a Peripheral cell?
primitive cell -- more aggresive

more mature cell --more indolent
Lymphocyte distribution (T/B):
1)in blood?
2)in BM?
3)in lymph nodes?
4)in spleen?
5)in GI tract lymph tissue?
6)in thymus?
7)in skin?
1)T cells
2)B cells
3)T cells
4)equal T and B cells
5)B cells
6)T cells
7)T cells, dendritic cells, and NK cells
When measuring a lymph node, what is the cut off for a lympadenopathy?
> 2 cm
Lymph Node Structure:
1)Where are T cells found?
2)B cells?
3)Macrophages and histiocytes?
1)parafollicular cortex
2)lymphoid follicles
If a tumor metastasizes to a LN, where does it usually get stuck?
subcapsular area
What are centrocytes and centroblasts? Where are they found?
B cells in different stages of activation, found in lymphoid follicles
MCC of acute nonspecific lymphadenitis?
viral infection
What is the morphology of chronic follicular hyperplasia?
follicles more prominent

RA, syphillis, giant lymph node hyperplasia (GLNH=Castleman’s disease)
What is the morphology of chronic paracortical hyperplasia?
T cells more prominent (in between follicles)

viral illness such as infectious mononucleosis (EBV), postvaccinial lymphadenitis
What is the morphology of chronic sinus histiocytosis?
very prominent macrophage activity, sinuses

tumors, lymphangiography, storage disease etc.
What are non-caseating granulomas seen w/?
____ lymphomas are more common in Western Hemisphere.
____ lymphomas are more common in Eastern Hemisphere.

What is an agent that has been associated w/ lymphoma (Non-hodgkin's lymphoma (NHL))?
H. pylori
What role does immunosuppression have on lymphoma?
predispose to lymphoma by altering immune regulation
What NHL is most frequent in the Western Hemisphere?
Follicular lymphoma, followed by Diffuse Large B cell
Highest age group to get lymphoma?
Which lymphoma is much more common in children?
Lymphoblastic Lymphoma
Which leukemia is only seen after age 60?
Chronic Lymphocytic Leukemia
What is meant by a LOW GRADE lymphoma?
favorable, indolent, long natural survival

Treatment: palliative rather than curative
What is meant by a INTERMEDIATE GRADE lymphoma?
aggressive disease w/ short survival (<3 years)
more aggresive treatment
What do we currently use for grading a lymphoma?
immunochemistry, NOT CELL SIZE
Morphology of B-cell Small Lymphocytic or Chronic Lymphocytic Leukemia (CLL)?
diffuse architecture, small monotonous cells, Smudge cells
Immunophenotype of B-cell Small Lymphocytic or Chronic Lymphocytic Leukemia (CLL)?
*****CD5+****, CD19+, CD20+, CD21+, CD23+, plus a surface immunoglobulin

CD5 is actually a T-cell marker, therefore it is an example of an ABERRANT MARKER, seen in lymphomas
Clinical features of B-cell Small Lymphocytic or Chronic Lymphocytic Leukemia (CLL)?
indolent, mostly asymptomatic

15-30% transform into High Grade Large Cell Lymphoma --- RICHTOR'S SYNDROME
Immunophenotype for Follicular Lymphoma (FL)?
CD20+ (B cell marker), CD10+ (follicular center cell marker), *****************CD5 and CD3 both NEGATIVE*******, kappa and lambda chain
What genetic marker is very specific for FL?
translocation (14:18)
What lymphoma has the highest prevalence in the BM?

What does Mantle Cell Lymphoma resemble?
B-Cell small CLL, but is very aggressive
Immunophenotype for MCL?
CD20+, CD19+, CD5+, **********CD23 NEGATIVE********, this is how you differentiate btwn CLL

Kappa or Lambda +, CYCLIN D+
Where is there high prevalence of MCL?

genetic characterisics?

Characteristics of Large Cell Lymphoma?
large, aggressive, mitotically active cells
Immunophenotype of B-cell type LCL?
CD19+, CD20+, CD22+, CD10+/-, and kappa or lambda +
Molecular phenotype of LCL?
t(3:22) as well
Most aggressive lymphoma?
Burkitt's lymphoma
What is the unique translocation seen in BL?
t(8:14), where C-Myc is overexpressed
Immunophenotype of BL?
B cell phenotype, CD19+, CD20+, CD22+
The African form of BL is?
endemic form, more often associated EBV, also associated w/ maxilla and mandible
The American form of BL is?
sporadic form, mostly found in abdomen, peritoneum, and ovaries
How do you differentiate the more immature Precursor B or T lymphoblastic Leukemia/Lymphoma?
tDt positive
What is Mycosis Fungoides?
very indolent skin condition

lymphoma at interface of dermis and epidermis

may see abscesses known as Pautrier's Abscesses

almost all cells are T cells
Typical location of lymphoma in adults?
node based

extra nodal
Typical growth of lymphoma in adults?
indolent growth

high grade tumor w/ rapid, aggressive tumor
Typical growth pattern of lymphoma in adults?
follicular pattern, cytology - pleomorphic

diffuse pattern, cytology - monomorphic
Adult lymphomas tend to secrete?