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10 Cards in this Set
- Front
- Back
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Explain the latent phase of a cancer.
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The latent phase of a cancer is the time from the inception of the cancer to the time that the tumor becomes detectable. At this point, there are at least a billion malignant cells present.
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With respect to chemotherapeutics, what is the definition of toxicity?
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The effects of a chemotherapeutic drug on the normal cells.
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How is cytotoxicity different from toxicity?
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Cytotoxicity refers to the effects of a drug on the neoplastic cell.
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What is the Skipper Hypothesis?
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The ability of chemotherapy to cure cancer is inversely proportional to the tumor burden
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True or False.
Chemocurable cancers can develop resistance. |
False.
Chemocurable cancers such as testicular, some lymphomas and leukemias, and Hodgkin's do not develop resistance to therapy. |
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What is the term used when the cytotoxicity of a drug critically depends on the schedule of drug administration?
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Schedule dependent cytotoxicity.
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What is dose-limiting toxicity and which is the most common type related to chemotherapy?
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Dose-limiting toxicity is the side effect that limits the dosing of that drug.
Myelosuppression is the most common dose-limiting side effect. |
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10-14 days after the administration of the chemotherapy, platelet and wbc counts generally fall. Why is this not an acute process?
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Because the effect of chemotherapy is not on the formed cells but on precursor cells in the bone marrow which are dividing.
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At what ANC level does a patient have an increased risk of infection with endogenous bacteria?
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When ANC<500
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What is a vesicant?
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It is a drug that causes blistering. They are highly reactive chemicals that combine with proteins and DNA, and other cellular components to result in cellular changes immediately after exposure.
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