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24 Cards in this Set
- Front
- Back
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How do patients with ovarian cancer die?
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Life-threatening electolyte imbalances and severe malnutrition (starve to death)
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Which type of therapy should NOT be used in ovarian cancer?
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Radiation therapy (overall survival does not change)
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Why might chemo not be as effective in ovarian cancer?
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Ovarian cancer cells may be slow-growing and slow-dividing
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What are alternatives in platinum-resistant/refractory ovarian cancer?
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Paclitaxel
Docetaxel Gemcitabine Doxorubicin Topotecan Etoposide Hormonal therapy |
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What change in therapy is recommended for platinum-sensitive ovarian cancer?
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Paclitaxel or docetaxel (weekly)
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Initially, ___% of ovarian tumors are chemosensitive, but within 18-24 months, ___% will relapse
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75% are sensitive
85% will relapse |
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What are the two major adverse effects of paclitaxel?
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1) Myelosuppression
2) Dose-limiting neutropenia |
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What drug has an off-label use for ovarian cancer?
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Docetaxel
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What are the three major adverse effects of cisplatin?
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1) Nephrotoxicity
2) Ototoxicity 3) Nausea/vomiting |
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Cisplatin's mechanism involves what four processes?
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1) Replication arrest
2) Transcription inhibition 3) Cell cycle arrest 4) DNA repair and apoptosis |
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What type of chemo has been used for ovarian cancer from the mid 90s to 2011?
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Platinum agent + taxane
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What type of chemo was used starting in the 1970s for ovarian cancer?
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Cisplatin
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What three conditions prevent surgical debulking in ovarian cancer?
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1) Unresectable disease
2) High-risk comorbidities 3) Stage 4 disease |
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What is the standard 1st-line chemotherapy for ovarian cancer?
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Platinum agent + taxane
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What is the standard 1st-line therapy for ovarian cancer?
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Surgical debulking
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Ovarian cancer is reduced in women after what procedure?
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Tubal ligation
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Early age of 1st pregnancy and older age of final pregnancy __________ risk of ovarian cancer
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decrease
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More children leads to _______ risk of ovarian cancer
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lower
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What are the five main symptoms of ovarian cancer?
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1) Abdominal swelling
2) Abdominal pain 3) Dyspepsia 4) Urinary frequency 5) Weight change |
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Ovarian cancer has a ___ cure rate
(high, low) |
low
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Ovarian cancer has a ___ response rate to chemo?
(high, low) |
high
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What is usually the cause of ovarian cancer?
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Idiopathic (unknown)
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What is the overall five-year survival percentage of all ovarian cancer?
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44%
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85-90% of malignant ovary tumors affect what type of cells?
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Epithelial
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