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31 Cards in this Set
- Front
- Back
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Bernstein said in ACCORD |
1- lowering blood sugar does not help cvs disease 2-ADA improve blood sugar eye nerve kidney but not heart 3-Lowering A1c bad for the heart |
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How many patient in accord trial and what is the question |
10,251 divide into below 6 and standard threapy 7-7.9 Question was is decrease ha1c decrease risk cvs out come ? |
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What is conclusion accord |
Higher mortality in intensive groups lead to discontinue the study after 3.5 years follow up |
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Who they split the 10251 in accord? |
Intensive 352 event and 257 died Standard 371 event and 203 died There association weight gain more than 10 kg |
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Who they split the 10251 in accord? |
Intensive 352 event and 257 died Standard 371 event and 203 died There association weight gain more than 10 kg |
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Other clinical trial what they say decrease HA1C |
1inc. 18% cvs event 1 inc A1c. 12-14 death 1 inc A1c. 37% retinopathy |
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Who they split the 10251 in accord? |
Intensive 352 event and 257 died Standard 371 event and 203 died There association weight gain more than 10 kg |
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Other clinical trial what they say decrease HA1C |
1inc. 18% cvs event 1 inc A1c. 12-14 death 1 inc A1c. 37% retinopathy |
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When they terminated ACCORD |
After 17 month |
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Who they split the 10251 in accord? |
Intensive 352 event and 257 died Standard 371 event and 203 died There association weight gain more than 10 kg |
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Other clinical trial what they say decrease HA1C |
1inc. 18% cvs event 1 inc A1c. 12-14 death 1 inc A1c. 37% retinopathy |
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When they terminated ACCORD |
After 17 month |
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What about method of ACCORD? |
Muticenter clinical study Uk and canada Sponsor by national heart lung and blood institute nhlbi 77 clinical center |
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Who they split the 10251 in accord? |
Intensive 352 event and 257 died Standard 371 event and 203 died There association weight gain more than 10 kg |
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Other clinical trial what they say decrease HA1C |
1inc. 18% cvs event 1 inc A1c. 12-14 death 1 inc A1c. 37% retinopathy |
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When they terminated ACCORD |
After 17 month |
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What about method of ACCORD? |
Muticenter clinical study Uk and canada Sponsor by national heart lung and blood institute nhlbi 77 clinical center |
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What about parcipatented Accord |
Age more than 40 to 79 + cvs event or two risk factors Athescleosis or albuminuria LVH |
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Who they split the 10251 in accord? |
Intensive 352 event and 257 died Standard 371 event and 203 died There association weight gain more than 10 kg |
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Other clinical trial what they say decrease HA1C |
1inc. 18% cvs event 1 inc A1c. 12-14 death 1 inc A1c. 37% retinopathy |
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When they terminated ACCORD |
After 17 month |
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What about method of ACCORD? |
Muticenter clinical study Uk and canada Sponsor by national heart lung and blood institute nhlbi 77 clinical center |
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What about parcipatented Accord |
Age more than 40 to 79 + cvs event or two risk factors Athescleosis or albuminuria LVH |
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What is criteria out from study? |
Fregancy hypo No complaince to hgm Bmi more than 45 Creatine more than 1.5 or other serious inllness |
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Who they split the 10251 in accord? |
Intensive 352 event and 257 died Standard 371 event and 203 died There association weight gain more than 10 kg |
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Other clinical trial what they say decrease HA1C |
1inc. 18% cvs event 1 inc A1c. 12-14 death 1 inc A1c. 37% retinopathy |
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When they terminated ACCORD |
After 17 month |
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What about method of ACCORD? |
Muticenter clinical study Uk and canada Sponsor by national heart lung and blood institute nhlbi 77 clinical center |
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What about parcipatented Accord |
Age more than 40 to 79 + cvs event or two risk factors Athescleosis or albuminuria LVH |
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What is criteria out from study? |
Fregancy hypo No complaince to hgm Bmi more than 45 Creatine more than 1.5 or other serious inllness |
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What is strength of the study and weakness |
Random Dollow up High risk people Bp control and lipid Weakness whte is the rate of lowering glucose is optimal |
