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15 Cards in this Set
- Front
- Back
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Which beta lactam is active ONLY against gram negative aerobic bacteria ?
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Aztreonam
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What organisms is Aztreonam active against ?
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N.gonorrhea
H flu P arugunosa |
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What type of diseases would indicate treatment with Aztreonam ?
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UTI's, URI, LRTI, intrabdominal and gynecological infections
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Can Aztreonam be given in pg >
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yes
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What are the Carbapemens ?
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Impenem (Primaxin)
Merrem (Metropenem) |
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How does the Carbapemems work ?
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bind to two ppb's and cause weakening of cell wall and death
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This feature of the Carbapenems broades its spectrum even further ...?
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it is resistant to practically ALL beta lactamases AND can penetrate the gram negative cell envelope
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Which is specifically approved for bacterial meningitis ?
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Meropenem is specifically approved for Bacterial Meningitis in kids 3 months and up
-also used for complicated intraabdominal infections |
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Which Rx has THE broadest antimicrobial spectrum of any drug ?
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Imipenem (Primaxin)
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Can any of the carbapenems be given PO ?
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no, all required IV or IM admin
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How are the carbapenems exceted ?
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renally
Imipenem must be combined with cilastatin to prevent it from being inactivated by an enzyme in the kidney |
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Is Imipenem the *best* choice for a P. Aruginosa infection ?
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No...when given alone to treat psuedemonas, resistance has been noted. Should be combined with another antipsuedemonal drug
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What are the common side effects ?
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pain at the site of injection
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What are the approved uses for Metropenem ?
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1. Bacterial meningitis in kids > 3 months
2. complicated intraabdominal infections |
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Imipenem is THE most effective beta lactam antibiotic for use against anerobic bacteria...TRUE OR FALSE ?
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TRUE.
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