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10 Cards in this Set
- Front
- Back
Achondroplasia- Genetics
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Autosomal Dominant
Mutation for Fibroblastic Growth Factor Receptor (FGFR3) on Chrom4 |
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Achondroplasia mechanism
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Inhibits normal cartilage proliferation
Fewer, disorganized chondrocytes Growth plate is thinned and transverse bar of bone seals it off |
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Osteogenesis Imperfecta- Genetics
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Autosomal Dominant
Type 1 Collagen gene mutations |
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Osteogenesis Imperfecta mechanism
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Brittle bones from collagen defects cause multiple fractures in one bone, blue sclera and loss of hearing
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Osteopetrosis
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Osteoclast activity inhibited causing abnormal bone remodeling
Dense bone forms in the marrow spaces "Marble bone disease" |
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Osteoporosis
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Most common acquired metabolic bone disease
Enhanced osteoclastic activity Thin trabeculae and cortical bone Mineral content normal Can lead to vertebral compression fracture |
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Osteomalacia
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"Rickets" in children
Failure of mineralization Osteoid produced but not calcified Growth plate is thick and disorganized |
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Pagets Disease
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Excessive resorption of bone (atypical osteoclasts) causes vigorous osteoblastic response
Paramyxovirus has been implicated Hat size increases Increased incidence of osteosarcoma |
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Osteomyelitis- Pyogenic
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From blood or direct penetration
Long bones (kids) Vertebra (adults) Staph Aureus or Salmonella (SCA) Sinus formation associated with Squamous Cell Carcinoma |
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Osteomyelitis- Tb
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Long bones- synovium
Vertebrae- Pott Disease (collapse) |