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8 Cards in this Set
- Front
- Back
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MOA organic nitrate
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-organic nitrates are converted to nitric oxide --> stimulates guanylate cyclase to increase cGMP --> dephosphorylates mysoin light chains --> vascular relaxation
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pharmacological effects of ON
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1. venous and arterial dilation
2. effect on coronary blood flow 3. pain relief of angina |
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venous and arterial dilation
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-effects on venous over arteries
-decrease preload and afterload --> decreased myocardial work, decrease O2 demand |
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effect on coronary blood flow
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-dilate large epicardial coronary arteries and collateral vessels
-increase O2 delivery to ischemic myocardium -reduce preload decreases diastolic intraventricular pressure |
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amyl nitrite
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dosage form - inhalant
-used for acute attacks |
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nitroglycerin
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dosage form - IV, SL, translingual spray, transmucosal tablet, oral, topical, transdermal
-used for acute for acute attacks |
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isosorbide dinitrate
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SQ, oral
-used for prophylaxis against attacks |
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adverse effects
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1. vasodilation - headache, flushing
2. hypotension - dizziness, weakness 3. orthostatic hypotension 4. reflex tachycardia |
