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8 Cards in this Set
- Front
- Back
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Reagents used in dehydrohalogenation
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KOH/ethanol
C2H5O-/ethanol K-O-C(CH3)3/tert-butyl ol (CH3)3COH |
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Ease of dehydrohalogenation of alkyl halides
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3>2>1
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Dehydrohalogenation involves removal of ....
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halogen atom tog with a H atom from a C adjacent to the one leaving the halogen
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...the more highly substituted alkene will be the major product.
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Zatiseu's Rule
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"more substituted" means
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the one with the greater # of alkyl groups directly attached to the double bonded C's.
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Exception to Zeitseu's Rule
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if dehydrohalogenation is carried out with a bulky hindered base such as Ktert-butoxide in tert-butyl ol, then the major product will be the less substituted ol.
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In the E2 elimination, the attacking base and the leaving group are generally as far apart as possible or ....
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anti or trans elimination
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....is absolutely required for E2 reactions
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Trans-elimination
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