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12 Cards in this Set
- Front
- Back
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What is the origin of a neuroblastoma?
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Originates in the:
Adrenal gland Sympathetic ganglion chain In the: Retroperitoneum Mediastinum |
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What % of patients with neuroblastoma, show evidence of orbital involvement?
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20%
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What are the SYSTEMIC symptoms of neuroblastoma?
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Abdominal fullness & pain
Vanous obstruction and odema HPT caused by renal vascular compromise Bone pain |
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What are typical cells in neuroblastoma?
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Small round blue cells
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How do you Dx neuroblastoma?
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1) Incisional biopsy
2) Urinanalysis: CATECHOLAMINES positive in 90-95% cases 3) CT: bony destruction |
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What is the Tx for neuroblastoma?
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Chemo
Radiation |
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What is the prognosis of neuroblastoma?
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Despite intensive tx with chemo and radiation, only 10-25% survive
Nonorbital neuroblastoma has a relatively good prognosis |
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In whom is the prognosis better?
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In children < 1 year
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What is a paraneoplastic symptom?
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Opsoclonus
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List 6 METASTATIC tumours that affect the orbit in children
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1) Neuroblastoma
2) Ewing Sarcoma 3) Wilms Tumour 4) Leukaemia 5) Lymphoma 6) Histocytosis |
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What is the epidemiology of neuroblastoma?
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One of the most COMMON childhood cancers
Most frequent source of metastasis to the orbit Mean age of dx is 2 years. |
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What are the most common ocular symptoms of neuroblastoma?
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Uni- or bilateral proptosis
Lid ecchymosis Eyelid swelling Ocular motility disturbances Ptosis Horner syndrome |
