Oral Biology Lectures 2

Front 1

Back 1

Cellular and Acellular cementum

A= Acellularcementum next to dentine

B= Cellular cementum around apical region

Front 2

Back 2

Incremental lines of salter

Front 3

Back 3

AEFC and CIFC

Front 4

Back 4

Gemination and fusion

Front 5

Back 5

Root dilaceration

Front 6

Back 6

Trauma to deciduous teeth

Front 7

Back 7

Sometimes there is a change in variety and shape of tooth

Front 8

Back 8

Odontoma

Front 9

Back 9

Odontoma

Front 10

Back 10

Amelongenesis imperfecta

Front 11

Back 11

Dentinogenesis imperfecta

Front 12

Back 12

Dentinogenesis imperfecta

Front 13

Back 13

Fluorosis and tetracycline staining

Front 14

Back 14

Enamel pearls

Front 15

Back 15

Hypercementosis

Front 16

Back 16

Reduced enamel epithelium

Derived from ameloblast and stratum intermedium layers of the enamel organ

May include remnants of the stellate reticulum and outer enamel epithelium

Front 17

Back 17

Primary enamel cuticle

Basal lamina of the reduced enamel epithelium

Front 18

Back 18

abc

Front 19

Back 19

The epithelium becomes shorter and is eventually replaced with the secondary junctional epithelium. The gingival sulcus forms during the replacement at a stage where further recession would expose the cementum

SJE contains some cells derived from the oral epithelium

Front 20

Back 20

Coatings of teeth during eruption

As the tip of the crown emerges the reduced enamel epithelium disintegrates and fuses with the oral epithelium. During this fusion apoptosis occurs

This becomes the primary junctional epithelium

Front 21

Back 21

Cleidocranial dysplasia/ Dystosis

Front 22

Back 22

Osteopetrotic mice 'stone bone' or 'marble bone disease'

Front 23

Back 23

Primary failure of tooth eruption

Front 24

Back 24

Alveolar bone crypt of mouse molar

Front 25

Back 25

Osteoclasts on alveolar bone surface

Front 26

Back 26

Front 27

Teeth that can be used for stem cell use

Back 27

Impacted third molars in young, middle and aged populations

Teeth extracted for ortho reasons

Primary teeth exfoliated

Teeth extracted due to irreversible perio

Gingiva thats been resected due to aesthetic or hyper plastic reasons

Front 28

DPSCs

Dental papilla stem cells

Back 28

Front 29

Back 29

Front 30

Back 30

Follicle and tooth germ

Front 31

Back 31

Rat alveolar bone showing the dental follicle (DF) surrounding an unerupted tooth (M1) encased in alveolar bone (AB)

SR= stellate reticulum

Front 32

Reduced enamel epithelium

Back 32

Thin multilayered epithelium that covers the enamel of an unerupted tooth

(naysmyths membrane)

Front 33

Primary enamel cuticle

Back 33

basal lamina lying between the reduced enamel epithelium and the enamel surface

(naysmyths membrane)

Front 34

Nasmyth's membrane

Back 34

reduced enamel epithelium and primary enamel cuticle

Front 35

Junctional epithelium

Back 35

portion of gingival epithelium that is attached to the tooth enamel on one side and gingival connective tissue on the other. The coronal end lines the base of the gingival sulcus. The primary function is as a permeable barrier layer involved in limiting and controlling infection of periodontium

Front 36

Acquired enamel cuticle

Back 36

Protective, acellular protein layer covering the enamel surface coronal to the gingival margin derived

Front 37

Dental biofilm

Back 37

Front 38

Inflamed junctional epithelium

Back 38

the EM of the junctional epithelium in inflamed gingiva

Marked distention of intracellular spaces by PMNs) that are migrating from the connective tissue toward the gingival sulcus.

Fluid exudate from the connective tissue also flows through the sulcus through the Intracel spaces.

Front 39

Healthy junctional epithelium

Back 39

orientated with long axis parallel to tooth surface

Intracell spaces narrow

Front 40

Back 40

Arrows show the junctional epithelia is the most permeable region of gingival epithelia

Front 41

Back 41

Bulls pemphigoid

Front 42

Back 42

Secondary junctional epithelium

IBL= internal basal lamina (faces tooth enamel)

EBL= External basal lamina (faces CT)

Attached to enamel surface via hemidesmosomes

Front 43

Back 43

Regeneration of tooth tissues

Periodontal diseases: stem cells (PDLSCs and DFPCs) and molecules ed PDGF BDNF

Dental caries/pulp injury: SCs= DPSCs, SHED, SCAP and molecules= BMPS, GDNF, BDNF

Front 44

Bright et al 2015

Back 44

irrespective of defect type of animal tissue used:

PDL SC implantation can result in beneficial outcome for periodontal regeneration

Front 45

Key factors for stem cell transplantation

Back 45

Use of multipoptent adult stem cells

Need singling molecules/inductive morphogenetic signals

Need growth factors

Need a scaffold: biodegradable material that can be a synthetic polymer or pressed bio product (e.g. collagen)

Front 46

applications of dental stem cells

Back 46

Front 47

Back 47

stem cells of apical papilla

Front 48

Back 48

Anodontia

Complete absence

VERY RARE

permanent dentition fail to form

Front 49

Back 49

Supplemental

Resembles normal tooth

U2 more common than L5 more common that U5

Front 50

Cherubim

Back 50

Familial multilocular cystic disease

Genetic

Autosomal dominant

SH3BP2 gene

Chromosome 4

Leads to abnormal bone due to the disruption of signalling pathways associated with the maintenance of bone

Front 51

Back 51

Cherubim

Multilocular cystic radiolucencies

Abscent UEs

Front 52

Back 52

Supernumerary

1-3% of the population

More females than males

Mesiodens

Paramolar (buccally)

Distomolar (Behind 8s)

Front 53

Back 53

who knows

Front 54

Back 54

Submerged Es

Front 55

Back 55

Dentigerous Cyst

Front 56

Back 56

Cherubim

Front 57

Back 57

Front 58

Back 58

Front 59

Back 59

Tetracycline staining

Front 60

Back 60

Amelgenesis imperfecta

usually autosomal dominant and affects both dentitions

Abrasion and attrition of enamel

No increase risk to caries

Front 61

Back 61

Fluorosis

Front 62

Back 62

Mulberry molars

Front 63

Back 63

Hutchinson's incisors

Front 64

Back 64

Effect of measles

Front 65

Back 65

Turner teeth

Front 66

Back 66

Hypohydrotic ectodermal dysplasia

absence of ectodermal structures

Usually X linked recessive (rare in females)

Most cases caused by defects of EDA genes

Fine/sparse hair

Defective fingernails

Absence of sweat glands and get hyperthermia

Front 67

Back 67

Hypohydrotic ectodermal dysplasia

Dental probs? Anodontia- due to failure of dental lamina to form

Hypodontia- any teeth formed are deformed with conical crowns and delayed in eruption

Front 68

Delaceration

Back 68

Crown of tooth displaced from normal alignment

Result of acute mechanical trauma

Front 69

Enamel pearl

Back 69

Nodule of enamel at ADJ on maxillary molars

HERS differentiate into ameloblasts

Front 70

Back 70

Dens in dente (dens invaginus)

invagination of dental papilla

may cause enamel linked cavity opening onto the surface of max incisors

Increases caries risk

Front 71

Back 71

Hypcementosis

Cleidocranial dysplasia

Hypophosphatasia (recessive autosomal)

Front 72

Back 72

Ghost teeth

Front 73

Back 73

short, blunt roots, partial/total obliteration of the pulp chamber and root canal by dentine

Front 74

Back 74

Double teeth

Front 75

Back 75

Taurodont

Front 76

Back 76

Delaceration

Front 77

Back 77

Scleroderma

Front 78

Back 78

Scleroderma