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13 Cards in this Set

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  • Back
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What are neuropeptides?
small proteins which act as NTs and bind to GPCRs
What breaks down neuropeptides?
Peptidases
What are the three opioid receptors?
mu kabba delta
opioids have 3 prepro-sequences all from the same precursor
What does GPCR inhibition of adenylyl cyclase do?
decreases cAMP (coupled to opening K channels) causing hyperpolarisation
MOA of opioid receptor
activates Gai--> inhibits adenylyl cyclase --> decreases cAMP which either decreases Ca conductance or increase K conductance
Opioids are:
compounds which bind to opioid receptors
Have analgesic effects
Opiates are
compounds derived from opium poppy
Name an opioid antagonist
Naloxone
treats overdose of opioid and addiction
Morphine passes BBB with difficulty why?
Its amphoteric
codeine and heroin can pass through easily
Name some opioids
morphine, codeine, heroin
Side effect of opioids
respiratory depression: breathing rate decreases
codeine is naturally occurring and is converted to?
morphine by CYP2D6
What is used to treat morphine addicts?
Methadone - opioid agonist --> no euphoric effects