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13 Cards in this Set
- Front
- Back
- 3rd side (hint)
What are neuropeptides?
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small proteins which act as NTs and bind to GPCRs
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What breaks down neuropeptides?
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Peptidases
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What are the three opioid receptors?
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mu kabba delta
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opioids have 3 prepro-sequences all from the same precursor
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What does GPCR inhibition of adenylyl cyclase do?
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decreases cAMP (coupled to opening K channels) causing hyperpolarisation
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MOA of opioid receptor
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activates Gai--> inhibits adenylyl cyclase --> decreases cAMP which either decreases Ca conductance or increase K conductance
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Opioids are:
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compounds which bind to opioid receptors
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Have analgesic effects
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Opiates are
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compounds derived from opium poppy
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Name an opioid antagonist
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Naloxone
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treats overdose of opioid and addiction
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Morphine passes BBB with difficulty why?
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Its amphoteric
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codeine and heroin can pass through easily
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Name some opioids
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morphine, codeine, heroin
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Side effect of opioids
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respiratory depression: breathing rate decreases
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codeine is naturally occurring and is converted to?
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morphine by CYP2D6
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What is used to treat morphine addicts?
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Methadone - opioid agonist --> no euphoric effects
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