Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
Opioid Receptor types & effects
|
mu -> supraspinal & spinal
morphine-like analgesia, respiratory depression, euphoria, physical dependence delta -> spinal analgesia -> enkephaline selective interaction kappa -> spinal analgesia -> miosis, sedation (pentazocine-like) |
|
|
Morphine Physiological Actions
|
"HECk of a DREAM"
↑Histamine & hormonal (↑Prolactin, ↓ GRH, CRH, CH, FSH, ACTH) Emesis Contract smooth mm (biliary & bladder/ureter) CV changes (orthostat hypo) Decreased cough, GI motility, uterine tone, Depress mental (sedation) Respiratory depression (also causes dilation of cerebral vasculature -> ↑ICP) Euphoria Analgesia Miosis |
|
|
Morphine acts on which receptors
|
mu (strong), delta (weak), kappa (weak)
|
|
|
Heroin differences from morphine and metabolism
|
lipid soluble -> CROSS BBB
glucuronide conjug -> urine & bile |
|
|
Treatment of morphine OD
|
atropine + naloxone (also diagnostic c/o reverses effects)
|
|
|
Codeine effects
|
same as morphine except:
anti-tussic less euphoria more effective orally |
|
|
Opioid alkaloid mnemonic
|
"CODE LEVels call for MORe HEROIN"
Codein, Levorphanol, Morphine/Hydromorphone, Heroin |
|
|
Codeine acts on which receptors
|
kappa (weak) and delta (weak)
|
|
|
Levorphanol what is it
routes of admin |
Strong opioid agonist
oral or parenteral |
|
|
Cross-tolerance to morphine
|
meperidine & codeine
|
