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26 Cards in this Set
- Front
- Back
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Morphine MOA includes:
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- Interact w/opioid receptors
- decr release of substance P - inhibit releasing NT carrying painful stimuli - acts on CNS |
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Morphine AE*:
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-euphoria
- emesis - respiratory depression - cardiovascular hypotension - histamine release |
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in addition to being an analgesic, morphine is also a...
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anti-tussive
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merperidine MOA:
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- interacts with opioid receptors
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merperidine AE:
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- hepatic metabolism --> noremperidine --> CONVULSIONS
- anxiety, tremor, muscle twitches |
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methadone MOA:
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MOA similar to morphine but LESS EUPHORIA, LONGER DURATION OF ACTION
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methadone indications:
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--controlled w/drawl of substance users
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methadone AE:
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physical dependence
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fentanyl indications:
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anesthesia --100xs more potent than morphine
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fentanyl MOA:
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-rapid onset (2-5 min) & short duration
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Routes of administration for fentanyl are:
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intrathecal
epidural IV oral (lollipop) transdermal patch |
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codeine MOA:
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less potent than morphine
less euphoria less addictive |
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codeine indications:
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- pain --use in combo with ASAP/ASA
- anti-tussive (OTC preparations) |
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codeine AE:
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constipation (need to treat this as well)
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oxycodone MOA:
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codeine analog --
oral prep --combine w/APAP and ASA |
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oxycodone indications:
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good alternative to morphine
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propoxyphene MOA:
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derivative of methadone (MOA similar to morphine --less euphoric & longer duration of action)
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propoxyphene indicatiosn:
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- weak analgesic
- used in combo with APAP/ASA - post pardum depressum |
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propoxyphene AE:
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- nausea
- anorexia - constipation - Toxic: confusion, hallucination, convulsion, respiratory depression |
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tramadol MOA:
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central acting analgesic
metabolism --active metabolite |
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tramadol indications:
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mild or moderate pain
(not for chronic use) |
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tramadol AE:
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- nausea/vomiting, dizziness
- dry mouth - sedation - headache Drug interactions: SSRIs/TCA |
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Name opioid antagonists:
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naloxone
natrexone |
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Naloxone and Natrexone MOA:
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- block opioid receptors
- rapidly reverse effect of opioid receptor - precipitate symptoms opiate withdrawl |
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Naloxone indications:
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- quick reverse of coma/respiratory depression of opioid overdose
- fast acting - precipitate symptoms of opiate withdrawl* |
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Natrexone indications:
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similar to Naloxone
-longer duration of action - used in rapid opioid detox |
