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13 Cards in this Set
- Front
- Back
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Morphine
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Strong Agonist
SE: Respiratory depression, Bronchoconstriction (not for Asthmatics) Pupillary constriction High 1st pass metabolism Metabolized to glucuronide in liver (neonates lack enzyme) Hypertensive Crisis w/ MAO inhib. |
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Methadone
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Actions similar to morphine
Longer duration of action ~24hrs. CNS depressants potentiate SE: Respiratory Depression |
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Meperidine
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Strong Agonist
NO pinpoint pupils Hypertensive crisis w/ MAO inhib. Incompatible w/ pentabarb, thiopental, heparin SE: Resp. Depression, Antimuscarinic effect, neg. ionotropic action |
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Fentanyl
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Strong Agonist
More potent and faster acting than morphine Hypertensive crisis w/ MAO inhib. Can cause resp. depression Incompatible w/ pentabarb, thiopental |
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Codein
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Mild Agonist
Usually used w/ aspirin or acetaminophine Effective as antitussive For phasic pain |
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Hydroxycodone
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Mild Agonist
Similar to codeine -more antitussive action -more addicting alcohol will augment CNS depression SE: Respiratory depression |
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Oxycodone
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Mild Agonist 10-12x more potent than codeine
Usually used w/ aspirin or acetaminophine SE: Respiratory depression, hepatotox. |
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Propoxyphene
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Mild Agonist
Less effective than codeine Fatalities w/ alcohol SE: respiratory depression |
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Buprenorphine
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Partial u agonist, k antagonist
*Slow dissociation from u receptors -used to reduce opiate addiction, and post op pain and CA SE: Respiratory Depression |
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Pentazocine
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k agonist, weak u & delta antagonist
-can precipitate withdrawl synd. in u dependent individuals SE: increase in BP (don't give IM). Respiratory Depression |
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Tramadol
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-Inhibits seratonin and NE reuptake
-Increase adverse effects of MAO inhib. SE: urine retention, constipation, RASH, anxiety |
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Naloxone
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Opioid Antagonist
Used in life threatening Narcotic OD Short half life 1-2 hrs. |
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Naltrexone
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Opioid Antagonist
Useful in detoxification long halflife SE: life threatening hepatotoxicity |
