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71 Cards in this Set

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Nitroglycerin (Nitrate)
Venodilator when < 100 mc
also some arterial dilation when > 100 mc.
Decreases preload
Nitroprusside (Nipride)
mostly arterial dilator. Decreases afterload
Nitroglycerin dose
open hearts: 10 - 100 mc/min

Nipride dose
open hearts: 0.3 - 5 mc/kg/min
Hydralazine (Apresoline)
direct peripheral arterial dilator
hydralazine dose
5 - 20 mg IVP q 4-6 hrs
list some colloids
blood, albumin, hexstend
list some crystalloids
salines, LR, Dextrose's
What advantage does LR have over other crystalloids
it acts as a buffer, corrects acidosis
Milrinone (Primacor)
peripheral arterial and venous dilator, decreases preload and afterload.
Primacor dose
Usually a bolus (not a gtt). 50 mc/kg
Brevibloc (esmolol)
Beta blocker (thus antiarrythmic too). Decreases contractility, heart rate and BP (decr. renin)
Cleviprex/clevidipine
Calcium channel blocker. Decreases afterload (vasodilates peripheral arterial and coronary), contractility, heartrate
Brevibloc dose
50 - 300 mc/kg/min
initiate for HR > 120 if SBP > 110
Dobutamine
B1 and mild B2 and alpha.
Increasing dose exponentially increases effect.
Increases CO, HR and contractility.
Decreases SVR
Dobutamine doses
open heart: 5 - 10 mc/kg/min
regular: 2-40 mc/kg/min
dopamine
low doses stimulate dopamine receptors, higher stimulate alpha and B1
low dose: kidney dilator
med dose: B1
high dose: alpha and B1
dopamine dose
Open heart: 2-7.5 mc/k/min
regular:
1-2mc/k/mi: renal
2-10mc/k/min: increase CO, SVR anad preload
>10: marked vasoconstriction (alpha)
Norepinephrine (Levophed)
Alpha and Beta 1
Increased contractility and vasoconstriction (nonselective)...so last resort drug
Levophed dose
8 - 12 mc/min
Epinephrine
Stimulates alpha and all betas
"selective vasoconstrictor: doesn't effect brain, heart, skeletal muscle-shunts blood.....thats why its code drug!)
epinephrine dose
open heart: 0.02 - 0.2 mc/kg/min
regular: 1-20mc/min
neosynephrine
pure alpha, peripheral vasoconstriction
neo dose
regular 40-200 mc/min
open heart: 20-50 mc/min
vasopressin (pitressin)
same as ADH
peripheral smooth muscle vasoconstriction and water reabsorption
vasopressin dose
40 units IVP in arrest
0.01 - 0.04 units/min
protamine
reverses heparin
protamine dose
25-50 mg IVP (usually given in OR)
Amicar
antifibrinolytic, preserves platelets and decreases blood loss in post operative bleeding
Factor VII
last resort post operative bleeding after blood has been administered. Systemic clotting! Watch CT's!
Brevibloc (esmolol) when to initiate...
beta blocker (B1 and B2)
initiate for HR > 120 if SBP is > 110
Esmolol gtt dose
50 mc/k/min - 300 mc/k/min to maintain HR < 120
Esmolol when to notify MD
notify before intiating
Notify if near max dose
notify with onset of 2nd/3rd degree HB
milrinone (Primacor)
usually just bolus,
incr. contractility and peripheral vasodilator (arterial & venous)
milrinone (Primacor) dose
50 mc/kg
Calcium channel blockers: list em
norvasc
cleviprex
cardizem
nicardepene (cardene)
Procardia
verapamil
Ca channel blocker
decreases afterload (SVR), decr. contractility, decr. HR, vasodilates (peripheral artery and coronary)
Beta 1 vs Beta 2
heart and kidnyes is B1
B2 is bronchial & vascular smooth muscle dilator
strict Beta 1's
metropolol
atenolol
esmolol
Nitro bag concentration
50 mg/ 250
nitroprusside concentration
50 mg/ 250
dobutamine concentration
250 mg /250 ml
dopamine concentration
400 mg/250 ml (1600 mc/ml)
norepi (levo) bag concentration
4 mg/ 250 ml (16 mc/ml)
epi bag concentration
2 mg/ 250 ml (8mc/ ml)
Neo bag concentration
20 mg/ 250 ml (80 mc/ml)
Vasopressin bag concentration
50 units/ 250 ml
Esmolol (Brevibloc) bag concentration
2.5 mg/ 250 ml (10 mc/ml)
Open heart target SBP
90-120
Open heart target SVR vs. normal
800 - 1400 (normal 900 - 1300)
Open heart target PAD vs. normal
10 -15 (normal 6 - 12)
Open heart target PCWP vs normal
10-15 (normal 8-12)
Open heart target Cardiac index
> 2 (normal 2.5 - 4)
open heart target urine output
> 30 ml/hr
open heart target SV02
> 65 % (normal 60 - 80%)
open heart target CVP
8-12 (normal 2-8)
SVO2
mixed venous oxygen saturation
the % of oxygen bound to hgb returning to right side of heart
especially useful if measured before and after changes are made to vent/gtts etc.
Tells us if tissues are getting enough oxygen
what does low SVO2 mean? high?
tissues are extracting more O2 than normal
a rise in SVO2 is usually good unless there is a concurrent rise in lactic acid (anaerobic metabolism!)
per standing orders, when would one want to initiate dopamine gtt? what gtt would you add next if ineffective?
HR < 100
SVR < 800
SBP < 90
if more required add epinephrine infusion
Per standing orders, when would one initiate epinephrine gtt?
HR < 100
SVR < 800
SBP < 90
titrate to keep SBP > 90
per standing orders, when would I initiate Nicardipine (Cardene) infusion?
SBP > 120
titrate for SBP 90 - 120
nicardepene (cardene) dose
1 mg/hr, max dose 12 mg/hr
per standing orders, when could I initiate Cleviprex gtt?
SBP > 120, titrate for SBP 90 -120
Cleviprex gtt dosing
2 mg/hr, max 10 mg/hr
Per standing orders, when could I initiate Nitroglycerin gtt?
SBP > 120, titrate SBP 90-120
Per standing orders when could I initiate Brevibloc (esmolol)?
Notify surgeon first
initiate for HR > 120 only if SBP > 110
to maintain HR < 120
Per standing orders, when could I initiate dobutamine gtt?
Notify surgeon first
initiate for CI < 2
SVR > 1400
SBP < 90
titrate to keep SBP > 90
Per standing orders, when could I initiate phenylephrine (neo) gtt?
notify surgeon before initiating
for SVR < 800
titrate for SBP > 90
Per standing orders, when can I initiate amiodarone gtt?
Notify surgeon first
for new onset a -fib
Per standing orders, when can I give sodium bicarbonate?
1 amp IV q hour PRN for pH < 7.32
and
base excess < -5 in addition to vent changes to correct acidosis
3 vaso gtts that are in mc/min
Neo
Norepi (levo)
Nitro