One=Liners-Pathology

Front 1

primary adenocortical deficiency

Back 1

addison's disease

Front 2

pernicious anemia (antibodies to intrinsic factor or parietal cells --> decreased IF--> decreased Vit B12--> megaloblastic anemia

Back 2

addisonian anemia

Front 3

polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature, young girls

Back 3

albright's syndrome

Front 4

hereditary nephritis with nerve deafness

Back 4

alport's syndrome

Front 5

progressive dementia

Back 5

alzheimer's

Front 6

*loss of light reflex constriction (contralater or bilateral), * prostitutes eye - accomodation but does not react, * pathognomonic for tertiary syphilis, *lesion pretectal region of the superior colliculus

Back 6

argyll-robertson pupil

Front 7

cerebellar tonsil herniation through foramen magnum = see thoracolumbar meningomyelocele

Back 7

Arnold-Chiari malformation

Front 8

columnar metaplasia of lower esophagus (increased risk of adenocarcinoma) constant gastroesophageal reflux

Back 8

barrett's esophagus

Front 9

hyperreninemia

Back 9

Bartter's syndrome

Front 10

similar to Duchenne, but less severe (mutation not a deficiency in dystrophin protein)

Back 10

Becker's Muscular Dystrophy

Front 11

CN 7 palsy (entire face, recall that UMN lesion only affect the lower face)

Back 11

Bell's palsy

Front 12

IgA nephropathy causing hematuria in kids usually following infection

Back 12

Berger's disease

Front 13

defect in platelet adhesion (abnormally large platelets and lack of platelet surface glycoprotein)

Back 13

Bernard Soulier Disease

Front 14

circle of willis (subarachnoid bleed) anterior communicating artery, often associated with ADPKD

Back 14

berry aneurysm

Front 15

recurrences of rickettsia prowazaki up to 50 years later

Back 15

Brill-Zinsser disease

Front 16

somatoization disorder, psychological multiple physical complaints without physical pathology

Back 16

Briquet's syndrome

Front 17

motor aphasia (area 44 and 45) intact comprehension

Back 17

Broca's aphasia

Front 18

hemisection of cord (contralateral loss of pain and temp/ ipsilateral loss of fine touch, UMN/ ipsilateral loss of conscious proprioception

Back 18

Brown-Sequard

Front 19

X linked agammaglobinemia (decreased B cells)

Back 19

Bruton's disease

Front 20

post hepatic venous thrombosis = abdominal pain, hepatomegaly, ascites, portal HTN, liver failure

Back 20

Budd-Chiari

Front 21

acute inflammation of medium and small arteries of extremities --> painful ischemia --> gangrene , seen almost exclusively in young and middle aged men who smoke

Back 21

Buerger's disease

Front 22

small nocleaved cell lymphoma (EBV), 8:14 translocation, seen commonly in jaws, abdomen, retroperitoneal soft tissues, starry sky appearance

Back 22

Burkitt's lymphoma

Front 23

nitric gas emboli

Back 23

Caisson disease

Front 24

trypansoma infection-cardiomegaly with apical atrophy, achalasia

Back 24

chagas disease

Front 25

Autosomal recessive, phagocyte deficiency = defect in microtubule polymerization, neutropenia, albinism, cranial and peripheral neuropathy and repeated infections with strep and Staph

Back 25

Chediak-Higashi disease

Front 26

primary aldosteronism: HTN, retian Na+ and H2O, hypOkalemia (causing alkalosis) and decreased renin

Back 26

Conn's syndrome

Front 27

type III glycogenosis-glycogen storage disease (debranching enzyme:amylo1,6glucosidase deficiency. increased glycogen)

Back 27

Cori's disease

Front 28

prion infection --> cerebellar and cerebral degeneration

Back 28

Creutzfeldt-Jakob

Front 29

congenital hyperbilirubinemia (unconjugated), glucuronyl transferase deficiency. can progress to Kernicterus, less severe form will respond to phenobarbital therapy

Back 29

Crigler-Najjar Syndrome

Front 30

IBD, Ileocecum, transmural, skip lesions, cobblestones, lymphocytic infiltrate, granulomas, (contrast to UC: limited to colon, mucosa and submucosa, crypt abscesses, pseudopolyps, increased colon cancer risk) clinically presents with abdominal pain and diarrhea, fever, malabsorption, fistuale btw intestinal loops and abd structures

Back 30

crohn's

Front 31

acute gastric ulce associated with severe burns

Back 31

Curling's ulcer

Front 32

disease: hypercorticism secondary to increased ACTH form pituitary (basophilic adenoma), syndrome: hypercorticism of all other causes (primary adrenal or ectopic), -->moon face; buffalo hump, purple striae, hirsutism, HTN, hyperglycemia

Back 32

Cushing's

Front 33

acute gastric ulcer associated with CNS trauma?

Back 33

Cushing's Ulcer

Front 34

self limiting focal destruction (subacute thyroiditis)

Back 34

de Quervain's Thyroiditis

Front 35

fail;ure of the 3rd and 4th pharyngeal pouches to form: thymus & parathyroid, thymic hyperplasia -->T cell deficiency, hypoparathyroidism --> tetany

Back 35

DiGeorge's Syndrome

Front 36

trisomy 21 or translocation, simian crease

Back 36

Down's syndrome

Front 37

post MI fibrinous pericarditis (autoimmune)

Back 37

Dressler's syndrome

Front 38

congenital hyperbilirubinemia (conjugated) =bilirubin transport is defective not conjugation, striking brown to black discoloration of the liver

Back 38

Dubin-Johnson Syndrome

Front 39

deficiency of dystrophin protein --> MD (X linked recessive)

Back 39

Duchenne Muscular Dystrophy

Front 40

trisomy 18, rocker bottom feet, low ears, small lower jaw, heart disease

Back 40

Edward's Syndrome

Front 41

defective collagen

Back 41

ehler's danlos

Front 42

late cyanotic shunt (R --> L) pulmonary HTN and RVH secondary to long standing VSD, ASD or PDA

Back 42

Eisenmenger's complex

Front 43

trauma to superior trunk of brachial plexus (waiter's tip)

Back 43

Erb-Duchenne Palsy

Front 44

malignant undifferentitated round cell tumor of bone in boys ( <15 years - translocation 11;22

Back 44

Ewing Sarcoma

Front 45

carcinoma in situ on glans penis

Back 45

Erythroplasia of Queyrat

Front 46

impaired proximal tubular reabsorption secondary to lead poisoning or Tetracycline (glycosuria, hperphosphaturia, aminoaciduria, systemic acidosis)

Back 46

fanconi's syndrome

Front 47

rheumatoid arthritis, neutropenia, splenomegaly?

Back 47

felty's syndrome

Front 48

autosomal dominant, adenomatous polyps of colon, osteomas, and soft tissue tumors

Back 48

Gardner's syndrome

Front 49

lysosomal stroage disease (glucocerebrosidase deficiency - glucocerebroside accumulation), hepatosplenomegaly, femoral head an dlong bone erosion, anemia

Back 49

Gaucher's disease

Front 50

benign congenital hyperbilirubinemia (unconjugated) = decreased d glucuronyl transferase activity

Back 50

Gilbert's syndrome

Front 51

defective glycoproteins on platelets = deficient platelet aggregation

Back 51

Glanzmann's thrombasthenia

Front 52

autoimmune: antibodies to glomerular and alveolar basement membranes. seen in men in their 20's

Back 52

Goodpasture's

Front 53

autoimmune hyperthyroidism (TSI): IgG Ab reacitve with TSH receptors. Low TSH and TRH - High T3 and T4

Back 53

Grave's disease

Front 54

polyneuritis following viral infection / autoimmune (ascending muscle weakness and paralysis usually self limiting)

Back 54

Guillain-Barre

Front 55

idiopathic pulmonary fibrosis. can see honey comb lung

Back 55

Hamman-Rich syndrome

Front 56

chronic progressive histiocytosis

Back 56

Hand-Schuller-Christian

Front 57

autoimmune hypothyroidism. may have transient hyperthyroidism. Low T3/T4 and high TSH

Back 57

hashimoto's thyroiditis

Front 58

initial hyperthyroidism in hashimoto's thyroiditis that precedes hypOthyroidism

Back 58

Hasitoxicosis

Front 59

hypersensitivity vasculitis = allergic purpura. lesions have SAME age. hemmorhagic urticaria (with fever, arthralgias, GI and renal involvement, associated with upper respiratory infections

Back 59

Henoch-Schonlein purpura

Front 60

aganglionic megacolon

Back 60

hirschprung's disease

Front 61

ptosis, miosis, anhidrosis (lesion of cervical sympathetic nerves secondary to pancoast tumor)

Back 61

Horner's syndrome

Front 62

autosomal dominant, progressive degeneration of caudate nucleus, putamen (striatum) and frontal cortex decrease in GABA

Back 62

Huntington's (chromosome 4)

Front 63

epileptic events originating in the primary motor cortex (area 4)

Back 63

Jacksonian Seizures

Front 64

immune deficiency: neutrophils fail to respond to chemotactic stimuli, defective neutrophilic chemotactic response= repeated infections, commonly seen in light skinned, red-haired girls, increased levels of IgE

Back 64

Job's syndrome

Front 65

malignant vascular tumor (HHV8 in homosexual men)

Back 65

Kaposi sarcoma

Front 66

immotile cilia secondary to defective dynein arms (infection, situs inversus, sterility)

Back 66

Kartagener's syndrome

Front 67

mucocutaneous lymphnode syndrome in kids (acute necrotizing vasculitis of lips, oral mucosa)

Back 67

Kawasaki disease

Front 68

47, XXY: long arms, sterile hypogonadism

Back 68

Klinefelter's syndrome

Front 69

bilateral lesions of amygdala (hypersexuality; oral behavior)

Back 69

Kluver-Bucy

Front 70

adenocarcinoma with signet ring cells (typically originatic from the stomach) metastases to the ovaries

Back 70

Kruckenberg Tumor

Front 71

alcoholic cirrhosis

Back 71

LAennec's Cirrhosis

Front 72

HGPRT deficiency, Gout, retardation, self mutilation

Back 72

Lesch-Nyhan

Front 73

acute disseminated Langerhans' cell histiocytosis

Back 73

Letterer-Siwe

Front 74

endocarditis with small vegetations on valve leaflets, associated with SLE

Back 74

Libman-Sacks

Front 75

amyotrophic lateral sclerosis degeneration of the upper and lower motor neurons

Back 75

Lou Gehrig's

Front 76

bleeding from esophagogastric lacerations secondary to wretching (alcoholics)

Back 76

Mallory-Weis syndrome

Front 77

connective tissue defect: defective fibrillin gene (dissecting aortic aneurysm, subluxation fo lenses)

Back 77

Marfan's

Front 78

type V glycogenosis - glycogen storage disease (muscle phorphorylase deficiency = increased glycogen)

Back 78

McArdle's Disease

Front 79

rule of 2s: 2 inches long, 2 feet from ileocecum, 2% of population, embryonic duct origin, may have extopic tissue; gastric/pancreatic (remnant of VITELINE DUCT/ yolk stalk)

Back 79

meckel's diverticulum

Front 80

triad: ovarian fibroma, ascites, hydrothorax -associated with fibroma of ovaries

Back 80

Meig's Syndrome

Front 81

giant hypertrophic gastritis (enlarged rugae; plasma protein loss)

Back 81

Menetrier's Disease

Front 82

calcification of the media (usually radial and ulnar arteries)

Back 82

monckeberg's arteriosclerosis

Front 83

factitious disorder (consciously creates symptoms but does not know why)

Back 83

Munchausen syndrome

Front 84

primary adrenal cushings-->surgical removal of adrenals-->loss of negative feedback to pituitary-->pituitary adenoma

Back 84

Nelson's syndrome

Front 85

lysosomal storage disease (sphingomyelinase deficiency -sphingomyelin accumulation), foamy histiocytes

Back 85

Niemann-Pick

Front 86

hereditary hemorrhagic telangiectasia. seen in the Mormon's of Utah

Back 86

Osler-Weber-Rendu Syndrome

Front 87

abnormal bone architecture (thickened, numerous fractures--> pain)

Back 87

Paget's disease

Front 88

bronchogenic tumor with superior sulcus involvement --> horner's syndrome

Back 88

Pancoast tumor

Front 89

dopamine depletion in nigrostriatal tracts

Back 89

parkinson's

Front 90

melanin pigmentation of lips, mouth, hand, genitalia + hamartomatous polyps of small intestine

Back 90

Peutz-Jegher's Syndrome (Autosomal dominant)

Front 91

subcutaneous fibrosis of dorsum of penis

Back 91

peyronie's disease

Front 92

2 different diseases: 1. progressive dementia similar to alzheimers
2. constrictive pericarditis- sequel to mediastinal tuberculosis *calcium frosting unyielding layer-heart chambers may be unable to dilate to receive blood during diastole

Back 92

Pick's disease

Front 93

hyperthyroidism, nodular goiter, absence of eye signs (plummer's = graves -eye signs)

Back 93

Plummer's syndrome

Front 94

esophageal webs and iron deficiency anemai, spon shaped nails, Increased SCCA of esophagus

Back 94

Plummer-VInson

Front 95

type II gylcogenosis - glycogen storage disease--> cardiomegaly (alpha 1,4 glucosidase deficiency: increased glycogen)

Back 95

Pompe's disease

Front 96

tuberculous osteomyelitis of the vertebrae

Back 96

pott's disease

Front 97

renal agenesis-->oligohydraminos-->hypoplastic lungs, defects in extremities

Back 97

Potter's complex

Front 98

disease: recurrent vasospasm in extremities = seen in young healthy women
phenomenon: secondary to underlying disease (SLE or scleroderma)

Back 98

Raynaud's

Front 99

urethritis, conjunctivitis, arthritis, non infectious (but often follows infections), HLA-B27, polyarticular

Back 99

Reiter's syndrome

Front 100

microvesicular fatty liver change and encephalopathy, secondary to aspirin ingestion in children following viral illness, especially VZV

Back 100

Reye's syndrome

Front 101

idiopathic fibrous replacement of thyroid

Back 101

Riedel's thyroiditis

Front 102

congenital hyperbilirubinemia (CONJUGATED), similar to Dubin-Johnson but no discoloration fo the liver

Back 102

Rotor syndrome

Front 103

leukemic form of cutaneous T cell lyumphoma (mycosis fungoides)

Back 103

Sezary syndrome

Front 104

aluminum infalation -->lung fibrosis

Back 104

Shaver's disease

Front 105

postpartum pituitary necrosis = hemorrhage and shock usually occurred during delivery

Back 105

Sheehan's syndrome

Front 106

parkinsonism with autonomic dysfunction and orthostatic hypotension

Back 106

Shy=Drager

Front 107

pituitary cachexia can occur from either pituitary tumors or sheehan's

Back 107

Simmond's disease

Front 108

MEN type IIa = pheochromocytoma, thyroid medullary cancer, and hyperparathyroidism

Back 108

Sipple's syndrome

Front 109

triad: dry eyes, dry mouth, arthritis increased risk of B cell lymphoma

Back 109

Sjogren's syndrome

Front 110

juvenile melanoma (always benign)

Back 110

Spitz Nevus

Front 111

polycystic ovary: see amenorrhea, infertility, obesity, hirsutism = increased LH secretion

Back 111

Stein-LEventhal

Front 112

erythema multiforme, fever, malaise, mucosal ulceration (often secondary to infection =mycoplasma or sulfa drugs)

Back 112

Stevens-Johnson syndrome

Front 113

juvenile rheumatoid arthritis (absence of rheumatoid factor)

Back 113

Still's disease

Front 114

aortic arch syndrome, loss of carotid, radial or ulnar pulses = pulseless disease, night sweats. common in young asian females

Back 114

Takayasu's arteritis

Front 115

gangliosidosis (hexosaminidase A deficiency-->GM2 ganglioside) cherry red spots of the macula

Back 115

Tay-Sachs (autosomal recessive)

Front 116

1. VSD, 2. overriding aorta, 3. pulmonary artery stenosis, 4. right ventricular hypertrophy

Back 116

Tetralogy of Fallot

Front 117

involuntary actions, both motor and vocal Treat with Pimoxzide

Back 117

Tourette's syndrome

Front 118

colon adenomatous polyps plus CNS tumors

Back 118

Turcot's syndrome

Front 119

45, XO most common cause of primary amenorrhea. no barr body on buccal smear

Back 119

Turner's syndrome

Front 120

trench mouth, acute necrotizing ulcerative gingivitis due to Fusobacterium

Back 120

Vincent's infection

Front 121

type I glycodenosis - glycogen storage disease (G6Ptase deficiency)- glycogen accumulation

Back 121

Von Gierke's disease

Front 122

erythema multiforme, fever, malaise, mucosal ulceration (often secondary to infection =mycoplasma or sulfa drugs)

Back 122

Stevens-Johnson syndrome

Front 123

juvenile rheumatoid arthritis (absence of rheumatoid factor)

Back 123

Still's disease

Front 124

aortic arch syndrome, loss of carotid, radial or ulnar pulses = pulseless disease, night sweats. common in young asian females

Back 124

Takayasu's arteritis

Front 125

gangliosidosis (hexosaminidase A deficiency-->GM2 ganglioside) cherry red spots of the macula

Back 125

Tay-Sachs (autosomal recessive)

Front 126

1. VSD, 2. overriding aorta, 3. pulmonary artery stenosis, 4. right ventricular hypertrophy

Back 126

Tetralogy of Fallot

Front 127

involuntary actions, both motor and vocal Treat with Pimoxzide

Back 127

Tourette's syndrome

Front 128

colon adenomatous polyps plus CNS tumors

Back 128

Turcot's syndrome

Front 129

45, XO most common cause of primary amenorrhea. no barr body on buccal smear

Back 129

Turner's syndrome

Front 130

trench mouth, acute necrotizing ulcerative gingivitis due to Fusobacterium

Back 130

Vincent's infection

Front 131

type I glycodenosis - glycogen storage disease (G6Ptase deficiency)- glycogen accumulation

Back 131

Von Gierke's disease

Front 132

hemangioma (or hemangioblastoma) = cerebellum, brain stem, and retina, adenomas of the viscera especially increased renal cell carcinoma, Chromosome 3p

Back 132

Von Hippel-Lindau

Front 133

neurofibromatosis & cafe au lait spots and Lisch nodules (Chromosome 17)

Back 133

Von Recklinghausen's

Front 134

osteitis fibrosa cystica ("brown tumor") secondary to hyperparathyroidism = osteoclastic resorption with fibrous replacement

Back 134

Von Recklinghausen's disease of Bone

Front 135

defect in platelet adhesion secondary to deficiency in vWF increased aPPT, increased bleed time

Back 135

Von WIllebrand's disease (Autosomal dominant)

Front 136

proliferation of IgM producing lymphoid cells in men 50-70 years, PAS+, Dutcher bodies

Back 136

Waldenstrom's macroglobinemia

Front 137

posterior inferior cerebellar artery (PICA) thrombosis ("medullary syndrome"), ipsilateral ataxia, facial pain and temp loss, contralateral: body pain and temp loss

Back 137

Wallenberg's sydnrome

Front 138

adrenal insufficiency secondary to DIC, DIC secondary to mengiococcemia

Back 138

Waterhouse-Friderichsen

Front 139

paramedian infarc of midbrain, ipsilateral mydriasis, contralateral: UMN paralysis (lower face and body)

Back 139

Wber's syundrome

Front 140

necrotizing granulomatous vasculitis of paranasal sinuses, lungs, kidneys etc

Back 140

Wgener's granulomatosis

Front 141

icteric leptospirosis non icteric progresses to renal failure and myocarditis. Dark field microscopy for diagnosis

Back 141

Weil's disease

Front 142

MEN type I = thyroid, parathyroid, adrenal cortex, pancreatic islets, pituitary

Back 142

Wemer's syndrome

Front 143

sensory aphasia impaired comprehension

Back 143

Wernicke's aphasia

Front 144

thiamine deficiency in alcoholics; bilateral mamillary bodies (mediodorsal nucleus) (confusion, ataxia, opthalmopelgia)

Back 144

Wernicke-Korsakoff syndrome

Front 145

malabsorption syndrome (with bacteria laden macrophages) and polyarthritis

Back 145

Whipple's disease

Front 146

hepatolenticular degeneration (copper accumulation (treat with penicillamine) and decrease in ceruloplasmin, mallory bodies int eh liver and also with alcoholic hepatits and Hyaline change. Chromosome 13

Back 146

WIlson's disease

Front 147

immunodeficiency, combined B and T cell deficiency (thrombocytopenia and eczema) decreased IgM with increased IgA

Back 147

Wiskott-Aldrich syndrome

Front 148

high iodine level (-)'s thyroid hormone synthesis

Back 148

Wolff-Chaikoff effect

Front 149

esophage4al, cricopharyngeal muscles above UES

Back 149

Zenker's diverticulum

Front 150

gastrin secreting tumor of pancreas (or intestines) leads to increased acid -->recurrent ulcers

Back 150

Zollinger-Ellison

Front 151

interventricualr septal defect

Back 151

Roger's disease

Front 152

floppy valve syndrome - women b/t 20-40 yoa

Back 152

Barlow's syndrome

Front 153

minute abscesses found in subacute bacterial endocarditis

Back 153

Bracht-Wachter LEsions

Front 154

combination of septum secundum atrial septal defect with mitral stenosis

Back 154

Luternbacher's syndrome

Front 155

autoimmune thyroid disease (Hashimoto's) and insulin dependent diabetes

Back 155

Schmidt's syndrome