Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
28 Cards in this Set
- Front
- Back
|
5-FU
|
pyrimidine antimetabolite that blocks methylation of deoxyuricytic acid (blocks thymidine)
suicide inhibitor of thymidylate synthetase used with leucovorin/levamisole |
|
|
levamisole
|
modulates 5-FU activity and is an immune modulator
|
|
|
capecitabine
|
oral prodrug of 5-FU
carboxy-esterase in liver --> cytidine deaminase in liver/tumor --> thymidine phosphorylase in tumor |
|
|
cytarabine
|
nucleotide analog (Ara-C), prodrug that must be converted to triphosphate, inhibits DNA polyermase
|
|
|
gemcitabine
|
can be incorporated into DNA chains in place of cytosine and causes chain termination
|
|
|
fludarabine
|
nucleotide analog (Ara-A)
|
|
|
nelrabine
|
water-soluble prodrug of Ara-G
|
|
|
pentostatin
|
inhibits adenosine deaminase (increased adenosine levels inhibit RNA/DNA synth)
|
|
|
cladribine
|
inhibits adenosine deaminase (Cl atom makes it resistant to enzymatic attack)
|
|
|
mercaptopurine/thioguanine
|
prodrugs made into nucleotide precursors that block RNA/DNA synth
|
|
|
methotrexate
|
DHFR inhibitor
-uses leucovorin rescue |
|
|
pemetrexed
|
injectable; inhibits folypolyglutamate synthetase and DHFR
|
|
|
reasons for increase cell growth
|
increased ligand conc
increased # of receptors decreased receptor turnover receptor mutation |
|
|
imitinib, sorafenib, dasatinib, sunitinib, nilotinib
|
oral small molecules that inhibit multiple kinases
|
|
|
imitinib vs dasatinib
|
if resistant to imitinib, dasatinib may still works
-dasatinib's binding to ABL doesn't depend on P-loop (where mutaitons can occur) |
|
|
gefitinib, erlotinib, lapatinib
|
oral inhibitor of EGFR TK
|
|
|
cetuximab
|
IV Ab that inhibits EGFR dimerization
|
|
|
panitumumab
|
IV Ab that inhibits EGFR dimerization
|
|
|
temsirolimus
|
inhibits mTOR (immunosuppression and inhibits cancer cell/fungal growth)
|
|
|
endostatin
|
inhibits angiogenesis
|
|
|
bevacizumab
|
inhibits VEGF receptor
|
|
|
rituximab
|
binds CD20 on B cells and recruits Abs
|
|
|
herceptin
|
Ab that binds HER2 receptor (HER2 promotes breast cancer)
|
|
|
bexaar, oncolym, lymphocide
|
uses I-131
|
|
|
zavalin
|
uses yttrium-90 or indium-111
|
|
|
gemtuzumab
|
binds CD33, delivers calicheamicin into cells that binds DNA, forms diradical, cuts DNA and kills cell
|
|
|
IL-2, IFN-alpha
|
stims specific aspects of immune system
|
|
|
denileukin
|
NOT Ab (fusion protein)
binds IL-2 receptor on cancerous T-cells recognized by T-cells, taken up, attached diptheria toxin kills cell by inhibiting protein synthesis |
