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28 Cards in this Set
- Front
- Back
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M phase specific
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-vinca alkaloids
-taxanes |
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G0 phase specific
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-carmustine, lomustine
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G1 phase specific
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-asparaginase
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S phase specific
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-methotrexate
-cytarabine -fluorouracil -fludarabine -hydroxyurea |
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G2 phase specific
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-bleomycin
-etoposide, tenoposide |
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fluorouracil
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fluorinated pyrimidine metabolized to nucleotide fDUMP -> binds to thymidylate synthase (primary mech w/ continous infusion)
-triphosphate nucelotide metabolite incorporates into RNA as false metabolite (primary mech w/ intermittent bolus dosing) |
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capecitabine
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oral prodrug of 5-FU w/ tumor selectivity
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cytarabine
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penetrates cells via CMP -> phosphorylated to active triphosphate form (ara-CTP) -> inhibits DNA poly and incorporates itself into DNA
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gemcitabine
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inhibits DNA poly and ribonucleotide reductase
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fludarabine monophosphate
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fluorinated purine dephosphorylated in plasma -> activated within cell to triphosphate form (F-ara-ATP) -> inhibits DNA poly and transcription, blocks B and T cell function too
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methotrexate
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inhibits dihydrofolate reductase -> prevents DNA synthesis
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pemetrexed
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inhibits atleast 4 enzymes involved in folate metabolism and DNA synthesis
a)TS b)DHFR c)GARFT d)AICARFT |
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vinca alkaloids
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mitotic inhibitors or "spindle poisons"
-bind to tubulin inhibiting formation of mitotic spindle -> cells arrest in M phase |
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taxanes
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bind to tubulin and interfere with microtubule disassembly by inducing tubulin polymerization -> form stable but nonfunctional microtubules
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topoisomerase inhibitors
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forms complexes with topo I or II and DNA to inhibit strand rejoining after breakage (CCS=S or early G2)
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anthracyclines (doxorubicin, daunorubicin, idarubicin)
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-intercalation
-inhibition of topo II -free radical formation |
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anthracyclines (mitoxantrone)
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-intercalation
-less free radical formation (less cardiotoxicity) |
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alkylating agents
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form covalent bonds to result in cross-linking between DNA strands or between bases in same DNA strand ->inhibits DNA replication
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platinums (cisplatin)
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forms interstrand cross-linking of DNA-> prevent bases normally paired together from lining up
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trastuzamab
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HER2
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rituximab
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CD20 on B lymphocytes
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ibrotumomab tiuxetan
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anti-CD20 attached to radioactive yttrium (Y90)
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tositumomab
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anti-CD20 attached to radioactive iodine (I131)
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gemtuzumab
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anti-CD33
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alemtuzumab
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CD52 on T and B lymphocytes
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cetuximab
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EGFR
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bevacizumab
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VEGF preventing angiogenesis
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tyrosine kinase inhibitors
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"SIDES"
sorafenib, imatinib, desatinib, erlotinib, sunitinib |
