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28 Cards in this Set

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M phase specific
-vinca alkaloids
-taxanes
G0 phase specific
-carmustine, lomustine
G1 phase specific
-asparaginase
S phase specific
-methotrexate
-cytarabine
-fluorouracil
-fludarabine
-hydroxyurea
G2 phase specific
-bleomycin
-etoposide, tenoposide
fluorouracil
fluorinated pyrimidine metabolized to nucleotide fDUMP -> binds to thymidylate synthase (primary mech w/ continous infusion)
-triphosphate nucelotide metabolite incorporates into RNA as false metabolite (primary mech w/ intermittent bolus dosing)
capecitabine
oral prodrug of 5-FU w/ tumor selectivity
cytarabine
penetrates cells via CMP -> phosphorylated to active triphosphate form (ara-CTP) -> inhibits DNA poly and incorporates itself into DNA
gemcitabine
inhibits DNA poly and ribonucleotide reductase
fludarabine monophosphate
fluorinated purine dephosphorylated in plasma -> activated within cell to triphosphate form (F-ara-ATP) -> inhibits DNA poly and transcription, blocks B and T cell function too
methotrexate
inhibits dihydrofolate reductase -> prevents DNA synthesis
pemetrexed
inhibits atleast 4 enzymes involved in folate metabolism and DNA synthesis
a)TS
b)DHFR
c)GARFT
d)AICARFT
vinca alkaloids
mitotic inhibitors or "spindle poisons"
-bind to tubulin inhibiting formation of mitotic spindle
-> cells arrest in M phase
taxanes
bind to tubulin and interfere with microtubule disassembly by inducing tubulin polymerization -> form stable but nonfunctional microtubules
topoisomerase inhibitors
forms complexes with topo I or II and DNA to inhibit strand rejoining after breakage (CCS=S or early G2)
anthracyclines (doxorubicin, daunorubicin, idarubicin)
-intercalation
-inhibition of topo II
-free radical formation
anthracyclines (mitoxantrone)
-intercalation
-less free radical formation (less cardiotoxicity)
alkylating agents
form covalent bonds to result in cross-linking between DNA strands or between bases in same DNA strand ->inhibits DNA replication
platinums (cisplatin)
forms interstrand cross-linking of DNA-> prevent bases normally paired together from lining up
trastuzamab
HER2
rituximab
CD20 on B lymphocytes
ibrotumomab tiuxetan
anti-CD20 attached to radioactive yttrium (Y90)
tositumomab
anti-CD20 attached to radioactive iodine (I131)
gemtuzumab
anti-CD33
alemtuzumab
CD52 on T and B lymphocytes
cetuximab
EGFR
bevacizumab
VEGF preventing angiogenesis
tyrosine kinase inhibitors
"SIDES"
sorafenib, imatinib, desatinib, erlotinib, sunitinib