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7 Cards in this Set

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Monoclonal Antibody Drugs:
Rituximab
Trastuzamab
Gentuzumab
Bevacizumab
Cetuximab
Rituximab
Receptor and AE
Anti CD 20 (therefore anti B-Cell)
NHL and CLL

AE: Immunosuppressive -
black box re: hepatitis react.
Trastuzumab
Receptor and AE
(aka Herceptin) -> Her2Neu Receptor

AE: Cardio toxicity
Gemtuzumab
Receptor and AE
CD-33; AML

myelosuppression
Hepatotoxicity
Bevicizumab
Receptor and AE
VGEF (colon cancer)

BLACK BOX: impaired wound healing, GI perforation
Cetuximab
Receptor and AE
EGFR (Epithelial Growth Factor Receptor)

AE: acneiform rash (however, this is an indicator for better response)
Monoclonal Abs
MOA:
Apoptosis
Complement mediated cytotoxicity
Ab Dependent cellular toxicity
Radiolabeled Ab
Chemo-conjugated Ab