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5 Cards in this Set
- Front
- Back
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Antitumor Antibiotics
drug list |
Doxorubicin
Daunomycin Daunorubicin Rubidomycin Dactinomycin-D Bleomycin |
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Antitumor Antibiotics
MOA: |
Topoisomerase II inhibitor
intercalate DNA Fe used to make O2 free radicals -> cardiotoxicity passive diffusion |
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Antitumor Antibiotics
Adverse Effects |
Cardiotoxicity
Irreversible -> need to monitor drug give dexrazone (chelating agent) or Doxil for Cardio protection |
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Antitumor Antibiotics
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hepatic clearance
long half life |
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Doxorubicin
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Schedule anti-emetics
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