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5 Cards in this Set

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  • Back
Antitumor Antibiotics
drug list
Doxorubicin
Daunomycin
Daunorubicin
Rubidomycin
Dactinomycin-D
Bleomycin
Antitumor Antibiotics
MOA:
Topoisomerase II inhibitor
intercalate DNA

Fe used to make O2 free radicals -> cardiotoxicity

passive diffusion
Antitumor Antibiotics
Adverse Effects
Cardiotoxicity

Irreversible -> need to monitor drug

give dexrazone (chelating agent)
or Doxil for Cardio protection
Antitumor Antibiotics
hepatic clearance
long half life
Doxorubicin
Schedule anti-emetics