Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Nitrogen Mustards
Drug List |
Ifosfamide
Chlorambucil Melphalan Cyclophosphamide Mechlorethamine |
|
|
Cyclophosphamide / Ifosfamide
Pro and AE |
Pro: Good CNS penetration
AE: Bone Marrow Suppression Hemorrhagic cystitis Nephrotoxicity (HYDRATE) activated by CYP450 |
|
|
Mechlorathamine
AE |
AE: Severe Nausea and Vomiting
|
|
|
Melphalan
AE |
AE: Prolonged Bone Marrow Suppression
|
|
|
Chlorambucil
AE |
Requires anti-emetic
|
|
|
Nitrosouereas
Drug List |
Carmustine
Lomustine Semustine Streptozosin |
|
|
Carmustine/Lomustine
Pro and AE |
Pro: Good for CNS tumors (CSF levels =30%)
AE: prolonged bone marrow suppression |
|
|
Thiotepa
Class and AE |
Ethylenamines
AE: Severe Bone Marrow Suppression |
|
|
Busulfan
Class and AE |
Alkyl Sulfanate
AE: SEIZURES - need to premedicate(Lorazepam) Hepatotoxic |
|
|
Triazines
Drug List |
Dacarbazine (DCIT)
Procarbazine Temozolamide |
|
|
Dacarbazine
AE |
Nausea and Vomiting =>Premed
|
|
|
Temozalamide
Pro: |
Good CNS penetration! (works like DCIT)
|
|
|
Platinum Analogs
Drug List |
Cisplatin
Carboplatin Oxaliplatin |
|
|
Cisplatin
AE |
Synergistic action with Chemo or XRT
Nephrotoxic Peripheral Neuropathy - trouble walking |
|
|
Carboplatin
AE |
Marrow suppression (esp. platelets)
|
|
|
Oxaliplatin
AE |
Advanced Colorectal Cancer
AE: Peripheral Neuropathy |
|
|
Alkylating Agents
MOA: |
Interferes w/DNA fxn by alkylating
Induces cell death rapidly |
|
|
Alkylating Agents
Resistance: |
^ DNA repair - cut out bad parts
v Permeability occurs with monotherapy |
|
|
Alkylating Agents
Toxicities: |
Dose related
Marrow Suppression Mucositis Nephrotoxicity Alopecia |
