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19 Cards in this Set

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Nitrogen Mustards
Drug List
Ifosfamide
Chlorambucil
Melphalan
Cyclophosphamide
Mechlorethamine
Cyclophosphamide / Ifosfamide
Pro and AE
Pro: Good CNS penetration

AE: Bone Marrow Suppression
Hemorrhagic cystitis
Nephrotoxicity (HYDRATE)

activated by CYP450
Mechlorathamine
AE
AE: Severe Nausea and Vomiting
Melphalan
AE
AE: Prolonged Bone Marrow Suppression
Chlorambucil
AE
Requires anti-emetic
Nitrosouereas
Drug List
Carmustine
Lomustine
Semustine
Streptozosin
Carmustine/Lomustine
Pro and AE
Pro: Good for CNS tumors (CSF levels =30%)

AE: prolonged bone marrow suppression
Thiotepa
Class and AE
Ethylenamines

AE: Severe Bone Marrow Suppression
Busulfan
Class and AE
Alkyl Sulfanate

AE:
SEIZURES - need to premedicate(Lorazepam)

Hepatotoxic
Triazines
Drug List
Dacarbazine (DCIT)
Procarbazine
Temozolamide
Dacarbazine
AE
Nausea and Vomiting =>Premed
Temozalamide
Pro:
Good CNS penetration! (works like DCIT)
Platinum Analogs
Drug List
Cisplatin
Carboplatin
Oxaliplatin
Cisplatin
AE
Synergistic action with Chemo or XRT

Nephrotoxic
Peripheral Neuropathy - trouble walking
Carboplatin
AE
Marrow suppression (esp. platelets)
Oxaliplatin
AE
Advanced Colorectal Cancer

AE: Peripheral Neuropathy
Alkylating Agents
MOA:
Interferes w/DNA fxn by alkylating

Induces cell death rapidly
Alkylating Agents
Resistance:
^ DNA repair - cut out bad parts
v Permeability
occurs with monotherapy
Alkylating Agents
Toxicities:
Dose related
Marrow Suppression
Mucositis
Nephrotoxicity
Alopecia