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16 Cards in this Set
- Front
- Back
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AML Dx.- classification is based on:
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1. blast morphology
2. surface antigens specific for each cell type (id via flow cytometry of blast cells w/ monoclonal Abs.) 3. Histochemical Stains |
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Labs to order for AML Dx/ AML Px
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Important for Dx: cytochemistry, flow cytometry
Important for Px: cytogenetic analysis |
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Translocation in M3 (APL)
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Acute promylocytic leukemia: t(15;17)
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Parameters for FAB classifications
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cell morphology and cytochemical studies
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AML presentation
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dec. peripheral blood counts; anemia; infection; bleeding; pancytopenia; peripheral blood smear w/ blasts w/ Auer Rods
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Bone morrow percentage of blast cells in AML.
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20-30% nuclear blasts
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DDx AML vs. ALL
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Cytochemistry; detect enz in the cytoplasm of myeloid not lymphoid cells.
Myeloid (+): myeloperoxidase (MPO); located in granules also (+) Sudan Black and Esterase stains |
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AML Translation with a good prognosis.
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M3-APL t(15;17)
(ALSO (t 8;21/ t 16;16) |
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AML translations with bad Dx.
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lack of chomsome 5/7
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AML Tx
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supportive care- coagulopathies (DIC) more commmon w/ AML then ALL... req. FFP and PLT
- prevention of tumor lysis Chemo: all AML except M3 very intense 6-12 mo tx |
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remission (AML)
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<5% blasts in marrow- 0 in peripheral blood
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AML Tx FAB M3/APL
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All Trans-retinoic acid- 1yr- PO
and 3 cycles of Chemo (ATRA) 80% cure rate |
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ALL EPI
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primarily ages 2-10
no secondary leukemia cases adults have bad outcomes |
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AML Translations with good Px
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t(15;17) Acute promyelocytic leukemia
t(8;21) t(16;16) or inversion 16 |
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AML translations with bad Px
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-5
-7 |
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#1 finding in peripheral blood
blast cells |
auer rods
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