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16 Cards in this Set

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AML Dx.- classification is based on:
1. blast morphology
2. surface antigens specific for each cell type (id via flow cytometry of blast cells w/ monoclonal Abs.)
3. Histochemical Stains
Labs to order for AML Dx/ AML Px
Important for Dx: cytochemistry, flow cytometry

Important for Px: cytogenetic analysis
Translocation in M3 (APL)
Acute promylocytic leukemia: t(15;17)
Parameters for FAB classifications
cell morphology and cytochemical studies
AML presentation
dec. peripheral blood counts; anemia; infection; bleeding; pancytopenia; peripheral blood smear w/ blasts w/ Auer Rods
Bone morrow percentage of blast cells in AML.
20-30% nuclear blasts
DDx AML vs. ALL
Cytochemistry; detect enz in the cytoplasm of myeloid not lymphoid cells.
Myeloid (+):
myeloperoxidase (MPO); located in granules
also (+) Sudan Black and Esterase stains
AML Translation with a good prognosis.
M3-APL t(15;17)

(ALSO (t 8;21/ t 16;16)
AML translations with bad Dx.
lack of chomsome 5/7
AML Tx
supportive care- coagulopathies (DIC) more commmon w/ AML then ALL... req. FFP and PLT
- prevention of tumor lysis

Chemo: all AML except M3 very intense 6-12 mo tx
remission (AML)
<5% blasts in marrow- 0 in peripheral blood
AML Tx FAB M3/APL
All Trans-retinoic acid- 1yr- PO
and 3 cycles of Chemo
(ATRA)
80% cure rate
ALL EPI
primarily ages 2-10

no secondary leukemia cases

adults have bad outcomes
AML Translations with good Px
t(15;17) Acute promyelocytic leukemia
t(8;21)
t(16;16) or inversion 16
AML translations with bad Px
-5
-7
#1 finding in peripheral blood
blast cells
auer rods