Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
alkylating agents?
|
busulfan (Myleran)
cyclophosphamide (Cytooxan) ifosfamide (Ifex) |
|
platinum analogues?
|
carboplatin (Paraplatin)
cisplatin (Platinol) |
|
SE of cyclophosphamide?
|
hemorrhagic cystitis: dose-related, due to formation of acrolein to prevent give mesna (binds to acrolein) and hydrate
|
|
Use of cyclophosphamide?
|
neoplastic (RA, glomerular nephritis, idiopathic thrombocytopenic purpura) and non-neoplastic (breast, ovarian, prostate, lung)
|
|
SEs of oncology drugs?
|
CNS2, GI2, BMS- R, W, T, some alopecia, mucusitis, entagenic
|
|
what can ifosfamide (Ifex) cause?
|
acrolein metabolite, so give MESNA and hydrate
|
|
SEs of ifosfamide (Ifex)
|
hemorrhagic cystitis
CNS2: once experience CNS toxicity (lethargy, fatigue), d/c drug |
|
antibiotic for oncology
|
bleomycin (SE: pulmonary fibrosis)
|
|
SE: pulmonary fibrosis
|
bleomycin
busulfan amiodarone nitrofurantoin |
|
SE: cisplatin
|
nephro and ototoxicity (like aminoglycosides), prevent with hydration and amifostine
|
|
anthracyclines:
|
daunorubicin (Cerbidine)
doxorubicin (Adriamycin) idarubicin (Idamycin) |
|
Cerbidine
|
daunorubicin
|
|
Idamycin
|
idarubicin
|
|
Adriamycin
|
doxorubicin
|
|
Myleran
|
busulfan
|
|
Cytoxan
|
cyclophosphamide
|
|
SE of anthracycline:
|
cardiac toxic: give Zenicard (desrazasone)
|
|
use of anthracycline:
|
breast, ovarian, leukemias
|
|
lifetime dose of daunorubicin, doxorubicin:
|
550mg/m2
|
|
lifetime max dose of idarubicin:
|
137.5 mg/m2
|
|
dose of daunorubicin (Cerbidine):
|
60 mg/m2
|
|
dose of doxorubicin (Adriamycin)
|
12 mg/m2
|
|
desrazoxane
|
used to prevent cardiotoxcitiy in pts on anthracyclines
Zinecard |
|
antimetabolites
|
methotrexate (Amethopterin)
cytarabine (Cytosar) (Ara-C) |
|
high dose of methotrexate?
|
1 g/m2
|
|
uses of methotrexate:
|
solid tumors, lymphomas, RA, psoriasis
|
|
give what with MTX?
|
leucovorin- if not mucosal damage in GI tract and irrerversible BMS- R, W
dose: 10-100 mg/m2 q6h until MTX levels fall |
|
MTX will cause:
|
irreversible BMS: R, W if no leucovorin rescue along with GI mucosal damage
|
|
SE of cytarabine (Cytosar):
|
conjunctivits : will need corticosteroid eye drops
CNS1: slurring, forgetfulness |
|
most likely to cause mucositis:
|
MTX, Ara-C (cytarbine), 5-FU, anthracyclines, bleomycin
|
|
highly ematogenic 60-100%:
|
cisplatin, cyclophosphamide, Ara-C (cytarabine), MTX: give 5-HT3 antagonist
|
|
moderately ematogenic 10-60%
|
anthracyclines, carbaplatin: can give Reglan and dexamethasone
|
|
low ematogenic <10%:
|
bleomycin, busulfan, low dose MTX: give Phenergan and go up from there
|
|
MOA of Zofran
|
selectively antagonizes 5HT-3 receptors
|