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48 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
ONCOGENE
|
TUMOR
|
GENE PRODUCT
& MOA |
|
|
hst-1 & int-2
|
Stomach
Breast, Bladder & Melanoma |
--> Fibroblast growth factor
Overexpression |
|
|
sis
|
Astrocytoma
|
--> Platelet-derived growth factor
Overexpression |
|
|
erb-B1
|
SCC of Lung
|
--> Epidermal GF Receptor
Overexpression |
|
|
erb-B2
|
**BREAST**
Ovary, lung |
--> Epidermal GF Receptor
Amplification |
|
|
erb-B3
|
Breast
|
--> Epidermal GF Receptor
Overexpression |
|
|
ret
|
ENDOCRINE TUMORS:
*MEN II & III* Familial Thyroid (medullary) CA |
--> Glial neurotrophic factor
Point Mutation |
|
|
abl
|
CML, ALL
|
--> bcr-abl fusion protein!!!!!
W/ Tyrosine Kinase activity!! Translocation ***t(9;22)*** - must know! |
|
|
Ki-ras
|
Lung, pancreas, and colon
(lots of cancers) |
--> **GTP Binding protein**
Point Mutation |
|
|
c-myc
|
**Burkitt Lymphoma**
|
--> Nuclear Reg. Protein
Translocation ***t(8;14)*** |
|
|
L-myc
|
Small cell Lung carcinoma
|
--> Nuclear Reg. Protein
Amplification |
|
|
N-myc
|
*Neuroblastoma*
|
--> Nuclear Reg. Protein
Amplification |
|
|
bcl-1
|
Mantle cell lymphoma
|
--> Cyclin D protein
(Cell cycle regulatory protein) Translocation ***t(11;14)*** |
|
|
CDK4
|
Melanoma, GBM
|
--> Cyclin dependent kinase
(Cell cycle regulatory protein) Amplification |
|
|
TUMOR SUPPRESSOR GENE
|
CHROMOSOME
|
TUMORS
|
|
|
VHL
|
3p25
|
von Hippel-Lindau disease
Renal cell carcinoma |
|
|
WT-1
|
11p13
|
Wilm Tumor
|
|
|
WT-2
|
11p15
|
Wilm Tumor
|
|
|
Rb
|
13q14
|
Retinoblastoma, osteosarcoma
|
|
|
p53
|
17q13.1
|
Lung, breast, colon, basically every cancer...most commonly knocked out gene in cancers
|
|
|
BRCA-1
|
17q12-21
|
HEREDITARY Breast & Ovary cancer
|
|
|
BRCA-2
|
13q12-13
|
HEREDITARY Breast
|
|
|
APC
|
5q21
|
Adenomatous polyps & colon cancer
|
|
|
DCC
|
18q21
|
Colon Cancer
|
|
|
NF-1
|
17q11.2
|
Neurofibromas --> neurofibromin
Cafe au lat spots, Leish spots |
|
|
NF-2
|
22q12
|
Acoustic neuromas, meningiomas, Schwannomas
--> Merlin |
|
|
Regulation of Apoptosis
bcl-2 |
Follicular Non-hodgkin's lymphoma
|
Translocation 14;18
|
|
|
MONOCLONAL AB's
against CELLULAR COMPONENTS |
MONOCLONAL AB's
against CELLULAR COMPONENTS |
|
|
|
Thyroglobulin
|
Thyroid Cancer
|
|
|
|
S100
|
Melanoma & Neural Tumors
|
|
|
|
Actin
|
Smooth & Skeletal muscle
|
|
|
|
CD markers
|
Lymphoma/Leukemias
|
|
|
|
Estrogen Receptors
|
Breast Cancer
|
|
|
|
Intermediate Filament:
KERATIN |
Carcinomas
from All Epithelial cells |
|
|
|
Intermediate Filament:
VIMENTIN |
Sarcomas
from Mesenchymal cells |
|
|
|
Intermediate Filament:
DESMIN or ACTIN |
Uterine Leiomyoma
Rhabdomyosarcoma from Muscle Cells |
|
|
|
Intermediate Filament:
NEUROFILAMENT |
Pheochromocytoma
Neuroblastoma from CNS, PNS neurons and Neural CREST derivatives |
|
|
|
Intermediate Filament:
GFAP (Glial fibrillary acidic protein) |
Astrocytomas
Ependymomas Oligodendrogliomas from Glial Cells |
|
|
|
TUMOR MARKERS
|
TUMOR MARKERS
|
|
|
|
Alpha-Fetoprotein
(AFP) |
- Hepatoma
- Nonseminomatous testicular germ-cell tumors |
|
|
|
Beta - hCG
|
- Trophoblastic tumors
- Choriocarcinomas (hCG SKY HIGH) |
|
|
|
Calcitonin
|
Medullary carcinoma of the Thyroid
|
|
|
|
Carcinoembryonic Ag
(CEA) |
Carcinomas of:
- Lung - Pancreas - Stomach - Breast - Colon Non-specific, usu. used once they know the cancer, to monitor if tx is working. |
|
|
|
CA-125
|
Malignant Ovarian Cancer
|
|
|
|
CA19-9
|
Pancreatic cancer
+ CEA too |
|
|
|
Placental alkaline phosphatase
|
Seminoma
|
|
|
|
Prostatic Acid Phosphatase
|
Prostate Cancer
|
|
|
|
PSA
|
Prostate Cancer
|
|
