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10 Cards in this Set
- Front
- Back
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What is follicular hyperplasia?
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Follicular hyperplasia is a reactive proliferation of B lymphocytes in response to an increased need for antibody production.
Ex: strep throat |
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What do T and B cells express on flow cytometry?
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T cells express either CD4 or CD8.
B cells express both kappa and lambda light chains. |
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What is paracortical hyperplasia?
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Paracortical hyperplasia is a reactive proliferation of T lymphocytes in response to an increased need for cell-mediated immunity.
Ex: mono |
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What is sinus histiocytosis?
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Sinus histiocytosis is a proliferation of macrophages in the node (stimulation of antigen-presenting cells.)
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SLL and CLL both:
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Low grade,
have small, round lymphocytes, occur in older adults, are considered incurable, are mature B-cell diseases (CD19+, CD20+, CD22+, CD23+, coexpress CD5, kappa or lambda light chain) |
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Follicular Lymphoma:
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Low grade,
small, cleaved cells, occurs in adults, considered incurable, mature B-cell disease (CD19+, CD20+, CD22+, CD10+, kappa or lambda light chain) t(14:18), BCL2 |
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Diffuse Large B-Cell Lymphoma:
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Intermediate grade,
large cells, occurs in children and adults, low stage disease is curable, associated w/immune dysfunction, BCL6 |
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Lymphoblastic Lymphoma:
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Correlate of ALL,
High grade, mediastinal mass, occurs in children, immature T-cell disease (CD3, coexpresses CD4, CD8, TdT) |
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Burkitt's Lymphoma:
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Correlate of ALL L3,
High grade, macrophages with debris "starry sky," predominantly in children, associated w/EBV, mature B-cell disease t(18;14), t(2;8), t(8;22) MYC |
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Hodgkin's Lymphoma:
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Bimodal age distribution,
Reed-Sternberg cells = activated B cells, morphologic subtypes correlate with prognosis, |
