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16 Cards in this Set
- Front
- Back
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small lymphocytic lymphoma - No germinal centers, no sinuses – just a sheet
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a
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small lymphocytic lymphoma - No germinal centers, no sinuses – just a sheet
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a
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Small lymphocytes
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a
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Intermediate/mantle cell
lymphocytes |
a
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Small Cleaved lymphocytes
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a
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Diffuse Large B-Cell Lymphoma - Intermediate Grade
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a
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Lymphoblastic Lymphoma - High Grade
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a
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Lymphoblastic Lymphoma - High Grade
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a
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Burkitt’s Lymphoma - High Grade - Macrophages with debris form the “starry sky
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a
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Burkitt’s Lymphoma - involving the bone marrow - Characteristic cytoplasmic
vacuoles |
a
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small lymphocytic lymphoma (SLL)
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- low grade but not curable
- disease of the elderly - like CLL but in lymph - Mature B-cell - (CD19-23) co-expressing CD5, & κ or λ |
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follicular (small cleaved cell) lymphoma
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- low grade but incurable
- t(14;18) -> too much Bcl2 - Age and HIV determine - 2nd most common lymphoma - Mature B-cell (CD19, 20, 22) w/ CD10+ and κ or λ |
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Large Diffuse Cell Lymphoma
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- intermediate grade but curable w/ RCHOP + Rituximab
- Most common type of NHL - Can have B symptoms - BCL6 (3q26-27) is common, but is better prognosis - Transformation of germinal center centroblasts - 1/3 extranodal - GI, brain |
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Lymphoblastic Lymphoma
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- high grade
- Young, usually female - Ass. w/ mediastinal mass - Treated like ALL - T-cell w/ CD3, 4, 8 and TdT |
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Burkitt’s lymphoma
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- agressive - can get Tumor lysis syndrome -> renal probs
- abdominal mass - no EBV in US, but EBV in africa - Ass. w/ t(8;14) -> c-myc - like L3 ALL, w/ Mature B-cell phenotype |
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chromosomes usually involved w/ lymphoma
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- 14 (Ig heavy chain)
- 2 (k light chain) - 22 (l light chain) |
