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10 Cards in this Set
- Front
- Back
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Normal lymph node - Germinal centers and sinuses are present
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a
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Lymphoma - Note loss of architecture (absence of germinal centers and sinuses)
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a
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Normal bone marrow - Note the heterogeneity of cells in the normal bone marrow - Many red cell precursors, and granulocytes in different stages of maturation, are seen
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a
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Acute leukemia - Normal bone marrow cells have been replaced by leukemic blasts - Virtually no mature nucleated cells are seen
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a
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follicular hyperplasia
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a
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Follicular lymphoma - a type of mature B-cell lymphoma
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a
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This analysis was performed using fluorescently labeled antibodies to the B-cell antigen CD19 and to the kappa and lambda light chains - Note the presence of kappa and lambda light chains (benign)
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a
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This analysis was performed using fluorescently labeled antibodies to the B-cell antigen CD19 and to the kappa and lambda light chains - Note the
Predominance of kappa positive cells indicative of a monoclonal population (malignant) |
a
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testing for T cell clonality
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- precursor cells undergo gene rearrangement of the T-cell receptor genes
- Can detect using molecular studies (e.g. southern blot, PCR) |
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testing for B cell clonality
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- detect rearranged IG gene using molecular biology
- light chain restriction on the cell surface (k or l) - Secretion of monoclonal Ab |
