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10 Cards in this Set

  • Front
  • Back
Normal lymph node - Germinal centers and sinuses are present
a
Lymphoma - Note loss of architecture (absence of germinal centers and sinuses)
a
Normal bone marrow - Note the heterogeneity of cells in the normal bone marrow - Many red cell precursors, and granulocytes in different stages of maturation, are seen
a
Acute leukemia - Normal bone marrow cells have been replaced by leukemic blasts - Virtually no mature nucleated cells are seen
a
follicular hyperplasia
a
Follicular lymphoma - a type of mature B-cell lymphoma
a
This analysis was performed using fluorescently labeled antibodies to the B-cell antigen CD19 and to the kappa and lambda light chains - Note the presence of kappa and lambda light chains (benign)
a
This analysis was performed using fluorescently labeled antibodies to the B-cell antigen CD19 and to the kappa and lambda light chains - Note the
Predominance of kappa positive cells indicative of a monoclonal population (malignant)
a
testing for T cell clonality
- precursor cells undergo gene rearrangement of the T-cell receptor genes
- Can detect using molecular studies (e.g. southern blot, PCR)
testing for B cell clonality
- detect rearranged IG gene using molecular biology
- light chain restriction on the cell surface (k or l)
- Secretion of monoclonal Ab